Block copolymer matrix for transdermal drug release
    2.
    发明授权
    Block copolymer matrix for transdermal drug release 失效
    用于透皮药物释放的嵌段共聚物基质

    公开(公告)号:US4840796A

    公开(公告)日:1989-06-20

    申请号:US184748

    申请日:1988-04-22

    IPC分类号: A61K9/70 A61L15/58 C08G18/61

    摘要: A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a matrix containing a medicinally active ingredient, and a pressure sensitive adhesive for affixing the system to the skin of a patient; the improvement in such system is based on the fact that said matrix is drug permeable (including to hydrophilic drugs) and is formed of a copolymer which can be softened sufficiently at temperature between 45.degree. C. and 160.degree. C. to incorporate the drugs therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms "soft" segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 45.degree. C. and 160.degree. C. said soft segments comprising from 80 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.

    Electrically conductive compositions containing acrylate functional
organosiloxane/oxyalkylene copolymers and solubilized lithium salt
    3.
    发明授权
    Electrically conductive compositions containing acrylate functional organosiloxane/oxyalkylene copolymers and solubilized lithium salt 失效
    含有丙烯酸酯官能的有机硅氧烷/氧化烯共聚物和溶解的锂盐的导电组合物

    公开(公告)号:US4990360A

    公开(公告)日:1991-02-05

    申请号:US414541

    申请日:1989-09-29

    摘要: This invention provides novel liquid organosiloxane/graft-oxyalkylene copolymers that cure to yield solid materials. The copolymers can be cured by heating them in the presence of suitable curing agents, by exposure to ultraviolet radiation in the presence of a photoinitiator, or by exposure to an electron beam. The copolymers can be combined with solubilized, ionizable lithium salts to yield curable electroconductive compositions suitable for use as electrolytes in storage batteries.

    摘要翻译: 本发明提供了固化以产生固体材料的新型液体有机硅氧烷/接枝 - 氧化亚烷基共聚物。 可以通过在合适的固化剂存在下,通过在光引发剂的存在下暴露于紫外线辐射或通过暴露于电子束来加热共聚物来固化共聚物。 共聚物可以与溶解的可离子化的锂盐组合,以产生适合用作蓄电池中的电解质的可固化导电组合物。

    Moisture resistant polyurethanes derived from non-aromatic diisocyanates
    5.
    发明授权
    Moisture resistant polyurethanes derived from non-aromatic diisocyanates 失效
    衍生自非芳族二异氰酸酯的防水聚氨酯

    公开(公告)号:US4631329A

    公开(公告)日:1986-12-23

    申请号:US802880

    申请日:1985-11-29

    摘要: The reduction in tensile strength exhibited in high humidity environments by "soft" polyurethanes prepared from aliphatic or cycloaliphatic diisocyanates can be substantially reduced if the molar ratio of diisocyanate and chain extender to isocyanate-reactive species other than said chain extender in the reaction mixtures from which said polyurethanes are prepared is at least 4.

    摘要翻译: 在高湿度环境下,由脂肪族或脂环族二异氰酸酯制备的“软”聚氨酯可显着降低拉伸强度,如果反应混合物中二异氰酸酯和扩链剂与除扩链剂之外的异氰酸酯反应性物质的摩尔比 所述制备的聚氨酯至少为4。

    Matrix for release of active ingredients
    6.
    发明授权
    Matrix for release of active ingredients 失效
    用于释放活性成分的基质

    公开(公告)号:US5008115A

    公开(公告)日:1991-04-16

    申请号:US487478

    申请日:1990-03-02

    摘要: A matrix for delivery of active substances such as fragrances and pheromones into the atmosphere is provided which matrix is active substance permeable (including to hydrophilic substances) and is formed of a copolymer which can be softened sufficiently at temperature between 45.degree. C. and 160.degree. C. to incorporate the substances therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms hard segments, said copolymer having a glass transition temperature between 45.degree. C. and 160.degree. C. said soft segments comprising from 70 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.

    摘要翻译: 提供用于将活性物质如香料和信息素递送到大气中的基质,其中基质是活性物质可渗透的(包括亲水性物质),并且由可在45℃至160℃之间的温度下充分软化的共聚物形成 C.将所述物质并入其中而不受热或化学反应引起的损害,所述基质由基本上线性的嵌段共聚物形成,所述基本线性嵌段共聚物是在所述反应产物中形成软链段的聚二有机硅氧烷和形成硬链段的二异氰酸酯的反应产物, 所述共聚物的玻璃化转变温度在45℃至160℃之间。所述软链段包含70至99重量%,基于所述共聚物的重量,共聚物的平均分子量为15,000至500,000。

    Heat sealable membrane for transdermal drug release
    7.
    发明授权
    Heat sealable membrane for transdermal drug release 失效
    用于透皮药物释放的可热封膜

    公开(公告)号:US4951657A

    公开(公告)日:1990-08-28

    申请号:US184750

    申请日:1988-04-22

    摘要: A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50.degree. C. and 200.degree. C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

    Matrix for release of active ingredients
    9.
    发明授权
    Matrix for release of active ingredients 失效
    用于释放活性成分的基质

    公开(公告)号:US4908208A

    公开(公告)日:1990-03-13

    申请号:US184731

    申请日:1988-04-22

    摘要: A matrix for delivery of active substances such as fragrances and pheromones into the atmosphere is provided which matrix is active substance permeable (including to hydrophilic substances) and is formed of a copolymer which can be softened sufficiently at temperature between 45.degree. C. and 160.degree. C. to incorporate the substances therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms hard segments, said copolymer having a glass transition temperature between 45.degree. C. and 160.degree. C. said soft segments comprising from 70 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.