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公开(公告)号：US07288647B2
公开(公告)日：2007-10-30
申请号：US11359842
申请日：2006-02-22
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C12P17/188
摘要： The invention provides a process for recovering CCI-779 from mother liquors.
摘要翻译： 本发明提供了从母液中回收CCI-779的方法。
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公开(公告)号：US07384953B2
公开(公告)日：2008-06-10
申请号：US11359294
申请日：2006-02-22
IPC分类号： C07D498/18 , A61K31/435
CPC分类号： C07D498/18
摘要： Purified rapamycin and a chemical process for obtaining the purified rapamycin are described.
摘要翻译： 描述了纯化的雷帕霉素和用于获得纯化的雷帕霉素的化学方法。
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公开(公告)号：US20130012702A1
公开(公告)日：2013-01-10
申请号：US13618090
申请日：2012-09-14
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
IPC分类号： C07D413/06 , C07D209/96 , C07D403/10 , C07D265/14
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
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4.发明授权Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same 失效含有环状氨基甲酸酯和硫代氨基甲酸酯联芳基的氰基吡咯及其制备方法公开(公告)号：US08129524B2
公开(公告)日：2012-03-06
申请号：US13179730
申请日：2011-07-11
IPC分类号： C07D265/12 , C07D207/30
CPC分类号： C07D413/04 , C07D207/34
摘要： Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl. Compounds including 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl) benzoicacid methyl ester, 5-[4-amino-3-(1-hydroxy-1-methyl-ethyl)-phenyl]-1-methyl-1H-pyrrole-2-carbonitrile, and 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl)-phenyl-ethanone, or pharmaceutically acceptable salts thereof, and the uses thereof are also provided.
摘要翻译： 提供了含有氰基吡咯部分和下式的环状氨基甲酸酯和硫代氨基甲酸酯的方法：Z相同或不同，为H，任选取代的C 1 -C 6烷基或CORA; RA为H，任选取代的C 1至C 6烷基，任选取代的C 1至C 6烷氧基，或任选取代的C 1至C 6氨基烷基; Q相同或不同，为H，OH，NH 2，CN，卤素，任选取代的C 1至C 6烷基，任选取代的C 2至C 6烯基，任选取代的C 1至C 6炔基，任选取代的C 1至C 6烷氧基，任选取代的C 1至 C6氨基烷基或CORB; 且R B为H，任选取代的C 1至C 6烷基，任选取代的C 1至C 6烷氧基或任选取代的C 1至C 6氨基烷基。 包括2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基）苯甲酸甲酯，5- [4-氨基-3-（1-羟基-1-甲基 - 乙基） - 苯基] -1-甲基-1H-吡咯-2-甲腈和2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基） - 苯基 - 乙酮或其药学上可接受的盐， 并提供其用途。
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公开(公告)号：US07786297B2
公开(公告)日：2010-08-31
申请号：US11412016
申请日：2006-04-26
申请人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
发明人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
IPC分类号： C07D265/14
CPC分类号： C07D265/14 , C07D413/04
摘要： Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
摘要翻译： 提供微粉化的钠盐瓶，纯化的tanaproget Form I和微粉化的纯化的Tanaproget Form I。 还提供了含有一种或多种所制备的钛酸钠形式的组合物，使用一种或多种所制备的钛酸钠形式的方法，以及包含一种或多种所制备的钛酸钠形式的试剂盒。
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公开(公告)号：US07358246B2
公开(公告)日：2008-04-15
申请号：US11100860
申请日：2005-04-07
IPC分类号： C07D417/10 , C07D417/14 , A61K31/5415 , A61K31/547
CPC分类号： C07D413/04 , C07D403/04
摘要： Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
摘要翻译： 提供了硫酰胺化合物，特别是硫代酰胺吡咯化合物及其制备方法。 这些硫代酰胺化合物可用作孕激素受体调节剂，避孕和治疗孕激素相关性疾病。
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7.发明授权Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls 失效用于产生N-取代的吡咯-2-碳腈的反应性含硼衍生物以产生联芳基的偶联方法公开(公告)号：US08129523B2
公开(公告)日：2012-03-06
申请号：US12238530
申请日：2008-09-26
IPC分类号： C07D265/12
CPC分类号： C07D413/04 , C07F5/025
摘要： A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
摘要翻译： 提供了含硼化合物，硼酸盐，含有吡咯甲腈的硼化合物，N-取代吡咯-2-腈含硼化合物及其衍生物的方便的制备方法。 本发明还提供这些含硼化合物及其衍生物在偶联反应中的用途，以提供双芳基化合物。
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8.发明申请CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME 失效含有环状碳酸酯和硫代氨基甲酸酯的CYANOPYRROLE及其制备方法公开(公告)号：US20090306371A1
公开(公告)日：2009-12-10
申请号：US12508679
申请日：2009-07-24
IPC分类号： C07D207/337 , C07D265/36 , C07D265/18
CPC分类号： C07D413/04 , C07D207/34
摘要： Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl. Compounds including 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl)benzoic acid methyl ester, 5-[4-amino-3-(1-hydroxy-1-methyl-ethyl)-phenyl]-1-methyl-1H-pyrrole-2-carbonitrile, and 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl)-phenyl-ethanone, or pharmaceutically acceptable salts thereof, and the uses thereof are also provided.
摘要翻译： 提供了制备含有氰基吡咯部分和下式的环状氨基甲酸酯和硫代氨基甲酸酯的方法。 Z相同或不同，为H，任选取代的C 1 -C 6烷基或CORA; RA为H，任选取代的C 1至C 6烷基，任选取代的C 1至C 6烷氧基，或任选取代的C 1至C 6氨基烷基; Q相同或不同，为H，OH，NH 2，CN，卤素，任选取代的C 1至C 6烷基，任选取代的C 2至C 6烯基，任选取代的C 1至C 6炔基，任选取代的C 1至C 6烷氧基，任选取代的C 1至 C6氨基烷基或CORB; 且R B为H，任选取代的C 1至C 6烷基，任选取代的C 1至C 6烷氧基或任选取代的C 1至C 6氨基烷基。 包括2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基）苯甲酸甲酯，5- [4-氨基-3-（1-羟基-1-甲基 - 乙基） - 苯基] -1-甲基-1H-吡咯-2-甲腈和2-氨基-5-（5-氰基-1-甲基-1H-吡咯-2-基） - 苯基 - 乙酮或其药学上可接受的盐 ，并提供其用途。
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公开(公告)号：US07511071B2
公开(公告)日：2009-03-31
申请号：US12044287
申请日：2008-03-07
IPC分类号： C07D417/10 , C07D417/14 , A61K31/5415 , A61K31/547
CPC分类号： C07D413/04 , C07D403/04
摘要： Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
摘要翻译： 提供了硫酰胺化合物，特别是硫代酰胺吡咯化合物及其制备方法。 这些硫代酰胺化合物可用作孕激素受体调节剂，避孕和治疗孕激素相关性疾病。
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公开(公告)号：US08168672B2
公开(公告)日：2012-05-01
申请号：US12698472
申请日：2010-02-02
IPC分类号： A61K31/40 , C07D411/00
CPC分类号： C07D413/04 , C07D403/04
摘要： Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
摘要翻译： 提供了硫酰胺化合物，特别是硫代酰胺吡咯化合物及其制备方法。 这些硫代酰胺化合物可用作孕激素受体调节剂，避孕和治疗孕激素相关性疾病。
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