公开(公告)号：US08708237B2

公开(公告)日：2014-04-29

申请号：US12371907

申请日：2009-02-16

Applicant: Shou-Te Wei ,  Chia-Lin Wang

Inventor： Shou-Te Wei ,  Chia-Lin Wang

IPC: G06K7/10

CPC classification number: G06K19/06037

Abstract: In a data region of each microdot block on a microdot matrix, a coordinate of each the microdot block on the microdot matrix is encoded into a plurality of microdots included by the data region according to an encoding method based on Reflected Gray codes. With the aid of a unique changed bit between any two consecutive Reflected Gray codes, an estimated coordinate of a frame, which is fetched by scanning the microdot matrix, on the microdot matrix, may still be decoded even if no complete microdot block is fetched within the frame.

Abstract translation: 在微点矩阵上的每个微点块的数据区域中，根据基于反射格雷码的编码方法，将微点矩阵上的每个微点块的坐标编码为由数据区域包括的多个微点。 借助于任何两个连续的反射格雷码之间的唯一改变的位，即使在微点矩阵上扫描微点矩阵，通过扫描微点矩阵获取的帧的估计坐标也可能被解码，即使没有完整的微点块在 框架。

公开(公告)号：US20050230252A1

公开(公告)日：2005-10-20

申请号：US11064524

申请日：2005-02-22

Applicant: Fu Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

Inventor： Fu Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

IPC: B01L3/00 ,  C12Q1/00 ,  G01N27/27 ,  G01N27/30 ,  G01N33/487 ,  G01N33/543

CPC classification number: C12Q1/006 ,  B01L3/5023 ,  G01N27/3272 ,  G01N33/5438

Abstract: The present invention provides biosensor test devices for measuring the presence or amount of an analyte in a biological fluid. The devices have a base plate that has an electrode system embedded therein, and a hydrophilic porous material situated on the base plate. A hydrophobic protective layer is situated on the hydrophilic porous material, and a cover is placed on the hydrophobic protective layer to complete the device. Some embodiments also use an insulating layer, which can be situated between the base layer and the hydrophilic porous material. The cover of the device has an opening present therein, situated over the electrodes, so that the electrodes communicate with the exterior of the device through the groove. The insulating layer can also have a groove situated therein, which in one embodiment is placed to align with the groove in the cover. The invention also provides methods of manufacturing the devices, and methods of using them.

Abstract translation: 本发明提供用于测量生物流体中分析物的存在或量的生物传感器测试装置。 这些装置具有嵌入其中的电极系统的基板和位于基板上的亲水性多孔材料。 疏水性保护层位于亲水性多孔材料上，并且将覆盖物放置在疏水性保护层上以完成该装置。 一些实施例还使用可以位于基底层和亲水性多孔材料之间的绝缘层。 该装置的盖具有位于电极上方的开口，使得电极通过凹槽与装置的外部连通。 绝缘层还可以具有位于其中的凹槽，其在一个实施例中被放置成与盖中的凹槽对准。 本发明还提供了制造装置的方法及其使用方法。

公开(公告)号：US06726177B2

公开(公告)日：2004-04-27

申请号：US10187358

申请日：2002-07-02

Applicant: Chia-Lin Wang

Inventor： Chia-Lin Wang

IPC: F16K122

CPC classification number: F16K1/2263

Abstract: The valve with an improved junk ring structure is composed of a main body, a valve disk, a washer and a junk ring. The main body has on one side thereof a stepped surface of which the outermost end has a screw thread portion on the inner wall thereof, the main body has on an inner wall thereof a protrusion. An upper and a lower pivotally connecting block are provided on the valve disk, and are movably connected by an axle provided on the main body. The junk ring has on the outer wall of the periphery thereof a screw thread portion mating with the screw thread portion of the main body. The washer is placed between the main body and the junk ring. By the arrangement of two screw threads (or multiple screw threads) with an identical screwing direction provided respectively on both the screw thread portions of the main body and of the junk ring, the entire valve can be assembled firmer and more convenient, the threads can be formed on a lathe simultaneously to reduce the number of times and the cost of production.

Abstract translation: 具有改进的垃圾圈结构的阀门由主体，阀盘，垫圈和垃圾环组成。 主体的一侧具有台阶面，其最外端在其内壁上具有螺纹部分，主体在其内壁上具有突起。 上部和下部枢转连接块设置在阀盘上，并且通过设置在主体上的轴可移动地连接。 垃圾环在其周边的外壁上具有与主体的螺纹部分配合的螺纹部分。 洗衣机放置在主体和垃圾桶之间。 通过分别设置在主体和垃圾环两螺纹部分上的两个相同螺纹方向的螺纹（或多个螺纹）的布置，整个阀可以更加牢固并且更方便，螺纹可以 同时在车床上形成，以减少生产的次数和成本。

公开(公告)号：US07807043B2

公开(公告)日：2010-10-05

申请号：US11064524

申请日：2005-02-22

Applicant: Fu Hsiung Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

Inventor： Fu Hsiung Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

IPC: G01N27/327

CPC classification number: C12Q1/006 ,  B01L3/5023 ,  G01N27/3272 ,  G01N33/5438

Abstract: The present invention provides biosensor test devices for measuring the presence or amount of an analyte in a biological fluid. The devices have a base plate that has an electrode system embedded therein, and a hydrophilic porous material situated on the base plate. A hydrophobic protective layer is situated on the hydrophilic porous material, and a cover is placed on the hydrophobic protective layer to complete the device. Some embodiments also use an insulating layer, which can be situated between the base layer and the hydrophilic porous material. The cover of the device has an opening present therein, situated over the electrodes, so that the electrodes communicate with the exterior of the device through the groove. The insulating layer can also have a groove situated therein, which in one embodiment is placed to align with the groove in the cover. The invention also provides methods of manufacturing the devices, and methods of using them.

Abstract translation: 本发明提供用于测量生物流体中分析物的存在或量的生物传感器测试装置。 这些装置具有嵌入其中的电极系统的基板和位于基板上的亲水性多孔材料。 疏水性保护层位于亲水性多孔材料上，并且将覆盖物放置在疏水性保护层上以完成该装置。 一些实施例还使用可以位于基底层和亲水性多孔材料之间的绝缘层。 该装置的盖具有位于电极上方的开口，使得电极通过凹槽与装置的外部连通。 绝缘层还可以具有位于其中的凹槽，其在一个实施例中被放置成与盖中的凹槽对准。 本发明还提供了制造装置的方法及其使用方法。

公开(公告)号：US20050234492A1

公开(公告)日：2005-10-20

申请号：US11081791

申请日：2005-03-15

Applicant: Fu Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

Inventor： Fu Tsai ,  Jinn-nan Lin ,  Chia-Lin Wang

IPC: A61B5/15 ,  A61B17/32

CPC classification number: A61B5/15194 ,  A61B5/150022 ,  A61B5/150183 ,  A61B5/150259 ,  A61B5/150282 ,  A61B5/150412 ,  A61B5/150824 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519

Abstract: The present invention is directed to spring-activated devices and methods for lancing the skin to obtain a small amount of blood for metabolic testing. In one embodiment, the depth penetration of the lancet needle can be seen by the patient during lancing the skin. In another embodiment, the device has only five moving parts for cocking and firing, a plunger, two springs, a slider and a button. In order to reduce manufacturing costs, the number of parts used in the device has been reduced and their configuration has been simplified to reduce construction time, and thereby save on labor costs.

Abstract translation: 本发明涉及弹簧激活装置和用于穿刺皮肤以获得少量用于代谢测试的血液的方法。 在一个实施例中，在穿刺皮肤期间，患者可以看到柳叶刀针的深度穿透。 在另一个实施例中，该装置仅具有五个用于起动和击发的移动部件，一个柱塞，两个弹簧，滑块和按钮。 为了降低制造成本，已经减少了装置中使用的部件的数量，并且简化了它们的构造以减少施工时间，从而节省了劳动力成本。

公开(公告)号：US6071913A

公开(公告)日：2000-06-06

申请号：US987039

申请日：1997-12-09

Applicant: Paw-Hwa Yang ,  Pei-Ling Lee ,  Shan-Yen Chou ,  Chia-Lin Wang ,  Hsiao-Hwa Lu

Inventor： Paw-Hwa Yang ,  Pei-Ling Lee ,  Shan-Yen Chou ,  Chia-Lin Wang ,  Hsiao-Hwa Lu

IPC: C07D403/10 ,  C07D403/12 ,  C07D253/065 ,  A61K31/53

CPC classification number: C07D403/10 ,  C07D403/12

Abstract: Disclosed are novel 1,2,4-triazin-5-one biphenyl derivatives having structural formula (I) useful as non-peptide antagonists of angiotensin II receptor: ##STR1## where R.sub.1 represents alkyl, cycloalkyl, or substituted or unsubstituted aryl;R.sub.2 represents alkyl, substituted or unsubstituted aryl, or arylalkyl;A and D independently represent C--R.sub.3, N, NH or C.dbd.O, wherein when A and D independently denote C--R.sub.3 or N, b and c are independently a double bond, and when A and D independently denote NH or C.dbd.O, b and c are independently a single bond; provided that b and c are not both double bonds; andR.sub.3 is hydrogen, dialkylphosphonate or halogen;and pharmaceutically acceptable salts thereof.Also disclosed is the use of the compounds of formula (I) as non-peptide antagonists of angiotensin II receptor, in the treatment of cardiovascular diseases, in particular hypertension and congestive heart failure.

Abstract translation: 公开了具有结构式（I）的1,2,4-三嗪-5-酮联苯衍生物，其可用作血管紧张素II受体的非肽拮抗剂：其中R1代表烷基，环烷基或取代或未取代的芳基; R 2表示烷基，取代或未取代的芳基或芳基烷基; A和D独立地表示C-R3，N，NH或C = O，其中当A和D独立地表示C-R3或N时，b和c独立地是双键，并且当A和D独立地表示NH或C = O，b和c独立地为单键; b和c不是双键; 并且R 3是氢，二烷基膦酸酯或卤素; 及其药学上可接受的盐。 还公开了式（I）化合物作为血管紧张素II受体的非肽拮抗剂在治疗心血管疾病，特别是高血压和充血性心力衰竭中的用途。

公开(公告)号：US08834702B2

公开(公告)日：2014-09-16

申请号：US13320903

申请日：2010-05-24

Applicant: Jinn-Nan Lin ,  Chia-Lin Wang ,  Ziyi Zhang

Inventor： Jinn-Nan Lin ,  Chia-Lin Wang ,  Ziyi Zhang

IPC: G01N27/327 ,  G01N33/543 ,  C12Q1/00

CPC classification number: G01N33/5438 ,  C12Q1/005 ,  G01N27/3272

Abstract: A biosensor for quantifying an analyte in a sample and usage thereof are provided. The biosensor includes an insulative substrate, a cover, a sample supply port, an electrode system including at least a working electrode, a counter electrode and a third electrode, and a reaction layer at least formed over the working electrode. The third electrode, used for estimating whether the amount of the sample is sufficient, is disposed nearer to the sample supply port than the counter electrode is. Whether the amount of the added sample is sufficient is estimated by comparing the electrical current value detected between the working electrode and the counter electrode with the electrical current value detected between the working electrode and the third electrode. This invention has a simple structure and produces accurate measurements.

Abstract translation: 提供了用于量化样品中的分析物的生物传感器及其用途。 生物传感器包括绝缘基板，盖子，样品供给口，至少包括工作电极，对电极和第三电极的电极系统以及至少在工作电极上形成的反应层。 用于估计样品量是否足够的第三电极设置得比对电极更靠近样品供给口。 通过将检测到的工作电极和对电极之间的电流值与在工作电极和第三电极之间检测到的电流值进行比较来估计添加样品的量是否足够。 本发明具有简单的结构并产生精确的测量。

公开(公告)号：US20090224054A1

公开(公告)日：2009-09-10

申请号：US12371907

申请日：2009-02-16

Applicant: Shou-Te Wei ,  Chia-Lin Wang

Inventor： Shou-Te Wei ,  Chia-Lin Wang

IPC: G06K7/10 ,  G06K19/06 ,  H03M1/22

CPC classification number: G06K19/06037

Abstract: In a data region of each microdot block on a microdot matrix, a coordinate of each the microdot block on the microdot matrix is encoded into a plurality of microdots included by the data region according to an encoding method based on Reflected Gray codes. With the aid of a unique changed bit between any two consecutive Reflected Gray codes, an estimated coordinate of a frame, which is fetched by scanning the microdot matrix, on the microdot matrix, may still be decoded even if no complete microdot block is fetched within the frame.

Abstract translation: 在微点矩阵上的每个微点块的数据区域中，根据基于反射格雷码的编码方法，将微点矩阵上的每个微点块的坐标编码为由数据区域包括的多个微点。 借助于任何两个连续的反射格雷码之间的唯一改变的位，即使在微点矩阵上扫描微点矩阵，通过扫描微点矩阵获取的帧的估计坐标也可能被解码，即使没有完整的微点块在 框架。

公开(公告)号：US06759190B2

公开(公告)日：2004-07-06

申请号：US10173457

申请日：2002-06-15

Applicant: Jinn-Nan Lin ,  Chia-Lin Wang

Inventor： Jinn-Nan Lin ,  Chia-Lin Wang

IPC: C12Q100

CPC classification number: G01N33/525 ,  C12Q1/54 ,  Y10S435/968 ,  Y10S435/97

Abstract: One aspect of the present invention is a reagent test strip that includes: a) a top support layer including a sample aperture; b) a membrane that includes a reagent system for indicating the concentration of a target; c) a spreading layer; d) a bottom support layer including a measuring port in substantial alignment or approximate alignment with the sample aperture. Preferably, the membrane is affixed to the top support layer. Preferably, the membrane is positioned between the top support layer and the bottom support layer. Preferably, the spreading layer is positioned above the top support layer and in substantial or approximate alignment with the sample aperture. Preferably, a fluid applied to the spreading layer, passes through the sample aperture and contacts the membrane.

Abstract translation: 本发明的一个方面是试剂测试条，其包括：a）包括样品孔的顶部支撑层; b）膜，其包括用于指示靶的浓度的试剂系统; c）扩散层; d）底部支撑层，其包括基本对准或与样品孔近似对准的测量口。 优选地，膜固定到顶部支撑层。 优选地，膜位于顶部支撑层和底部支撑层之间。 优选地，扩散层位于顶部支撑层上方并且与样本孔基本上或近似对准。 优选地，施加到铺展层的流体通过样品孔并接触膜。

公开(公告)号：US5462964A

公开(公告)日：1995-10-31

申请号：US139444

申请日：1993-10-20

Applicant: John M. Fevig ,  Matthew M. Abelman ,  Eugene C. Amparo ,  Joseph Cacciola ,  Charles A. Kettner ,  Gregory J. Pacofsky ,  Chia-Lin Wang

Inventor： John M. Fevig ,  Matthew M. Abelman ,  Eugene C. Amparo ,  Joseph Cacciola ,  Charles A. Kettner ,  Gregory J. Pacofsky ,  Chia-Lin Wang

IPC: A61K38/00 ,  C07D207/16 ,  C07F5/02 ,  C07F9/572 ,  C07K5/06 ,  A61K31/40 ,  C07D207/04

CPC classification number: C07F5/025 ,  C07D207/16 ,  C07F9/5727 ,  C07K5/06191 ,  A61K38/00

Abstract: The present invention relates to the discovery of new C-terminal boronic acid dipeptide inhibitors of trypsin-like enzymes such as thrombin and pharmaceutical compositions thereof.

Abstract translation: 本发明涉及新胰蛋白酶类酶C末端硼酸二肽抑制剂如凝血酶及其药物组合物的发现。