公开(公告)号：US20150353561A1

公开(公告)日：2015-12-10

申请号：US14731786

申请日：2015-06-05

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta ARMANI ,  Carmelida CAPALDI ,  Jonathan Mark SUTTON ,  Robert Andrew HEALD

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K9/0075 ,  A61K9/008 ,  A61K31/519

Abstract: Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract translation: 本文所述的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US20170101413A1

公开(公告)日：2017-04-13

申请号：US15317274

申请日：2014-06-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian ALCARAZ ,  Robert Andrew HEALD ,  Jonathan Mark SUTTON ,  Elisabetta ARMANI ,  Carmelida CAPALDI

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in therapy.

公开(公告)号：US20160168101A1

公开(公告)日：2016-06-16

申请号：US14953183

申请日：2015-11-27

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta ARMANI ,  Carmelida CAPALDI ,  Jonathan Mark SUTTON ,  Robert Andrew HEALD

IPC: C07D233/70 ,  C07D405/14 ,  C07D401/14 ,  C07C309/29 ,  C07C53/06 ,  C07D403/04 ,  C07D403/14

CPC classification number: C07D233/70 ,  C07C53/06 ,  C07C309/29 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14

Abstract: Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract translation: 本文所述的式（I）化合物是具有人嗜中性粒细胞弹性蛋白酶（HNE）抑制性质的咪唑啉酮衍生物，可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US20180009787A1

公开(公告)日：2018-01-11

申请号：US15712366

申请日：2017-09-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark SUTTON ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: C07D403/04 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07C309/29

CPC classification number: C07D403/04 ,  C07C309/29 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated

公开(公告)号：US20170340611A1

公开(公告)日：2017-11-30

申请号：US15606154

申请日：2017-05-26

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark SUTTON ,  Robert Andrew HEALD ,  Andrew Stephen Robert JENNINGS ,  Carmelida CAPALDI ,  Elisabetta ARMANI

IPC: A61K31/4152 ,  C07D249/08 ,  C07D231/44 ,  C07D401/04 ,  A61K31/277

CPC classification number: A61K31/4152 ,  A61K31/277 ,  C07D231/44 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14

Abstract: Pyrazolone derivatives of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of diseases or conditions in which HNE is implicated.