公开(公告)号：US20120013046A1

公开(公告)日：2012-01-19

申请号：US12836318

申请日：2010-07-14

Applicant: Chih-Hui YANG ,  Keng-Shiang Huang ,  Yung-Sheng Lin

Inventor： Chih-Hui YANG ,  Keng-Shiang Huang ,  Yung-Sheng Lin

IPC: B29C47/00

CPC classification number: A61K9/5089 ,  A61K9/5036 ,  B05B5/082 ,  D01D5/0076

Abstract: An electrospinning manufacture for drug carriers is disclosed. The method comprises a preliminary step mixing a predetermined drug, an alginate, and a saline to obtain a mixture; an electric field establishing step providing a collection plate and an emitter filled with divalent cation agent and the mixture individually, wherein an electric field is applied to the collection plate and the emitter to form a voltage therebetween; and an electrospinning step sequentially dropping the mixture from the emitter into the divalent cation agent filled in the collection plate via the driving of the electric field, triggering a crosslinking-gelating reaction between the divalent cation and the alginate, wherein a plurality of gel particles is produced for a coating of the predetermined drug presenting a drug carrier performance.

Abstract translation: 公开了用于药物载体的静电纺丝制造。 该方法包括将预定药物，藻酸盐和盐水混合以获得混合物的预备步骤; 电场建立步骤，提供收集板和填充有二价阳离子剂的发射体和所述混合物，其中电场施加到收集板和发射极以在它们之间形成电压; 以及静电纺丝步骤，通过驱动电场，将混合物从发射体顺序滴落到填充在收集板中的二价阳离子剂中，引发二价阳离子和藻酸盐之间的交联凝胶化反应，其中多个凝胶颗粒为 产生用于呈现药物载体性能的预定药物的涂层。

公开(公告)号：US08480945B2

公开(公告)日：2013-07-09

申请号：US12836318

申请日：2010-07-14

Applicant: Chih-Hui Yang ,  Keng-Shiang Huang ,  Yung-Sheng Lin

Inventor： Chih-Hui Yang ,  Keng-Shiang Huang ,  Yung-Sheng Lin

IPC: B29C47/00

CPC classification number: A61K9/5089 ,  A61K9/5036 ,  B05B5/082 ,  D01D5/0076

Abstract: An electrospinning manufacture for drug carriers is disclosed. The method comprises a preliminary step mixing a predetermined drug, an alginate, and a saline to obtain a mixture; an electric field establishing step providing a collection plate and an emitter filled with divalent cation agent and the mixture individually, wherein an electric field is applied to the collection plate and the emitter to form a voltage therebetween; and an electrospinning step sequentially dropping the mixture from the emitter into the divalent cation agent filled in the collection plate via the driving of the electric field, triggering a crosslinking-gelating reaction between the divalent cation and the alginate, wherein a plurality of gel particles is produced for a coating of the predetermined drug presenting a drug carrier performance.

Abstract translation: 公开了用于药物载体的静电纺丝制造。 该方法包括将预定药物，藻酸盐和盐水混合以获得混合物的预备步骤; 电场建立步骤，提供收集板和填充有二价阳离子剂的发射体和所述混合物，其中电场施加到收集板和发射极以在它们之间形成电压; 以及静电纺丝步骤，通过驱动电场，将混合物从发射体顺序滴落到填充在收集板中的二价阳离子剂中，引发二价阳离子和藻酸盐之间的交联凝胶化反应，其中多个凝胶颗粒为 产生用于呈现药物载体性能的预定药物的涂层。

公开(公告)号：US20110256231A1

公开(公告)日：2011-10-20

申请号：US12763408

申请日：2010-04-20

Applicant: Yung-Sheng Lin ,  Chun-Ting Lin ,  Keng-Shiang Huang ,  Chih-Hui Yang ,  Sheng-Yi Hsiao ,  Chih-Cheng Huang ,  Shih-Feng Tseng

Inventor： Yung-Sheng Lin ,  Chun-Ting Lin ,  Keng-Shiang Huang ,  Chih-Hui Yang ,  Sheng-Yi Hsiao ,  Chih-Cheng Huang ,  Shih-Feng Tseng

IPC: A61K9/14

CPC classification number: A61K9/1647 ,  A61K9/1652 ,  A61K9/1694

Abstract: A method for preparing drug in hemisphere-shaped dosage form. A high molecular weight solution containing the drug is prepared, and the solution is then dropped on a base material. The interface phenomena between the solution and different base materials makes the drop of high molecular weight solution containing the drug form a hemisphere-shape. After solidifying by cross-link or evaporation, the drug in hemisphere-shaped dosage form is obtained. The advantages of the preparation method are a simple and fast process, and simple operation. Applications of the method to prepare a drug in hemisphere-shaped dosage form are also provided.

Abstract translation: 制备半球形剂型的药物的方法。 制备含有药物的高分子量溶液，然后将溶液滴在基材上。 溶液与不同基材之间的界面现象使得含有药物的高分子量溶液的下降形成半球形。 通过交联或蒸发固化后，得到半球形剂型。 制备方法的优点是简单快速的过程，操作简单。 还提供了制备半球形剂型药物的方法的应用。

公开(公告)号：US20110300606A1

公开(公告)日：2011-12-08

申请号：US12794457

申请日：2010-06-04

Applicant: Chih-Hui YANG ,  Keng-Shiang Huang ,  Ya-Hui Hsieh

Inventor： Chih-Hui YANG ,  Keng-Shiang Huang ,  Ya-Hui Hsieh

IPC: C12N1/14

CPC classification number: C12N1/14

Abstract: A formula of medium for culturing Cordyceps spp. comprises 1˜6 wt % of carbon sources, 0.8˜51.5 wt % of nitrogen sources, 2˜12 wt % of alginate and 86.2˜95.2 wt % of solvent.

Abstract translation: 培养冬虫夏草的培养基配方 包含1〜6重量％的碳源，0.8〜51.5重量％的氮源，2〜12重量％的藻酸盐和86.2〜95.2重量％的溶剂。

公开(公告)号：US20120009265A1

公开(公告)日：2012-01-12

申请号：US12834499

申请日：2010-07-12

Applicant: Chih-Hui Yang ,  Keng-Shiang Huang

Inventor： Chih-Hui Yang ,  Keng-Shiang Huang

IPC: A61K9/14 ,  A61P35/00

CPC classification number: A61K9/0009 ,  A61K9/5094

Abstract: A drug carrier comprises a substance, a paramagnetic particle, a rod-shaped light-absorbing particle and a drug. The paramagnetic particle, the drug and the rod-shaped light-absorbing particle absorbing light and generating heat are provided in the substance.

Abstract translation: 药物载体包括物质，顺磁性颗粒，棒状光吸收颗粒和药物。 在该物质中提供顺磁性粒子，药物和吸收光并产生热量的棒状吸光性粒子。

公开(公告)号：US20110300022A1

公开(公告)日：2011-12-08

申请号：US12794331

申请日：2010-06-04

Applicant: Chih-Hui Yang ,  Keng-Shiang Huang ,  Hsiang-Chen Hsu

Inventor： Chih-Hui Yang ,  Keng-Shiang Huang ,  Hsiang-Chen Hsu

IPC: G01N33/00

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/525

Abstract: A temperature-adjustable biochip assembly has a biochip with a microfluidic channel embedded inside and a temperature-controlling unit including a substance sited at a surface of the biochip, a cyclic guiding module passing through the substance, and a fluid flowed inside the cyclic guiding module, with the cyclic guiding module having a fluidic installed in the substance for guiding the fluid and a temperature-controlling component for modulating the temperature of fluid.

Abstract translation: 温度可调的生物芯片组件具有嵌入内部的微流体通道的生物芯片和包含位于生物芯片表面的物质的温度控制单元，通过该物质的循环引导模块和流过循环引导模块的流体 循环引导模块具有安装在用于引导流体的物质中的流体，并且用于调节流体温度的温度控制部件。