公开(公告)号：US20220409716A1

公开(公告)日：2022-12-29

申请号：US17763548

申请日：2020-09-24

申请人： Children's National Medical Center ,  The United States of America, as represented by the Secretary, Dept. of Health and Human Service

发明人： Michael Keller ,  Catherine Mary Bollard ,  Ryo Hanajiri ,  Gelina Sani ,  Lisbeth Kim Green ,  Jeff Cohen ,  Stanislav V. Sosnovtsev

IPC分类号： A61K39/12 ,  A61P31/14

摘要： The present disclosure provides adoptive T-cell compositions, therapies, and processes of manufacture that are tailored for treatment or prevention of a subject with a norovirus infection, and, in some embodiments, for those subjects who are candidates for hematopoietic stem cell treatments, subjects who have undergone hematopoietic stem cell treatments, and subjects that have, are diagnosed with or suspected of having primary immunodeficiency disorders.

公开(公告)号：US11649437B2

公开(公告)日：2023-05-16

申请号：US17152149

申请日：2021-01-19

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine M. Bollard ,  Conrad Russell Cruz ,  Patrick J. Hanley ,  Michael Keller

IPC分类号： A61K35/17 ,  C12N5/0783 ,  A61P31/00 ,  A61P37/04 ,  A61P15/00 ,  C07K14/54 ,  C07K14/55 ,  C07K14/73 ,  C07K14/705

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61P15/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/5412 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/59 ,  C12N2502/1121 ,  C12N2502/1157

摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.

公开(公告)号：US11999967B2

公开(公告)日：2024-06-04

申请号：US17168461

申请日：2021-02-05

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine M. Bollard ,  Conrad Russell Cruz ,  Patrick J. Hanley ,  Michael Keller

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P15/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  C07K14/73

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61P15/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/5412 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/59 ,  C12N2502/1121 ,  C12N2502/1157

摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.

公开(公告)号：US20210290747A1

公开(公告)日：2021-09-23

申请号：US17050829

申请日：2019-04-26

申请人： Children's National Medical Center

发明人： Patrick Hanley ,  Michael Keller

IPC分类号： A61K39/04 ,  A61P31/06 ,  C12N5/0783

摘要： The present disclosure relates, at least in part, to mycobacterial polynucleotides and polypeptides, to fragments or variants thereof, to cells comprising the mycobacterial polynucleotides and polypeptides, to cells comprising the mycobacterial polynucleotides and polypeptides, that are engineered to expand T-cells ex vivo, and to methods of use thereof.