公开(公告)号：US20240316329A1

公开(公告)日：2024-09-26

申请号：US18259529

申请日：2021-12-23

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Lori IRVIN ,  Jules SHERMAN

IPC分类号： A61M39/10

CPC分类号： A61M39/1011 ,  A61M2039/1066 ,  A61M2205/0205

摘要： Aspects of the disclosure provide a connection protector and a securement system including the connection protector. For example, the connection protector can include a first cover portion and a second cover portion, a combination of which forms an internal compartment configured to enclose a connection point of a first conveying device and a second conveying device. A hinge can be coupled to first sides of the first and second cover portions, enabling the first and second cover portions to be in open or close position. Two openings can be formed on both ends of the first and second cover portions, allowing the first and second conveying devices to pass therethrough, respectively. A first tamper-proof locking assembly attached to second sides of the first and second cover portions, the first tamper-proof locking assembly configured to lock the first cover portion to the second cover portion.

公开(公告)号：US20240268752A1

公开(公告)日：2024-08-15

申请号：US18561080

申请日：2022-06-09

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Cindy COLSON

IPC分类号： A61B5/00 ,  G06T7/00 ,  G06T7/62 ,  G16H70/60

CPC分类号： A61B5/445 ,  G06T7/0012 ,  G06T7/62 ,  G16H70/60 ,  G06T2207/30088

摘要： A method for determining a burn percentage of a patient, including presenting, via processing circuitry, an image of at least one segment of a body, receiving, via the processing circuitry, a burn indication representing areas within the at least one segment of the body that have sustained a burn, determining, via the processing circuitry, a burned percentage of the at least one segment of the body based on the burn indication, determining, via the processing circuitry, a surface area of the at least one segment of the body based on an age of the patient and a weight of the patient, and determining, via the processing circuitry, the burn percentage of the patient based on the burned percentage of the at least one segment of the body and the surface area of the at least one segment of the body.

公开(公告)号：US20240216507A1

公开(公告)日：2024-07-04

申请号：US17907180

申请日：2021-03-22

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Michael KELLER ,  Chris LAZARSKI ,  Allistair ABRAHAM ,  Patrick HANLEY ,  Conrad Russell Y. CRUZ

IPC分类号： A61K39/00 ,  C12N5/0783

CPC分类号： A61K39/4611 ,  A61K39/464838 ,  C12N5/0636 ,  C12N2501/2304 ,  C12N2501/2307

摘要： The invention pertains to a method for preventing or treating SARS-CoV-2 infection by administering SARS-CoV-2 specific T cells which recognize particular peptide epitopes in SARS-CoV-2 spike (S), nucleocapsid (N), membrane, and envelope proteins.

公开(公告)号：US11880980B2

公开(公告)日：2024-01-23

申请号：US16309825

申请日：2017-06-19

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Marius George Linguraru ,  Juan Jose Cerrolaza ,  Craig Andrew Peters

IPC分类号： G06T7/12 ,  G06T7/13 ,  G06T7/155 ,  G16H50/20 ,  G16H30/40 ,  A61B5/20 ,  A61B5/00 ,  G06T7/00 ,  G06T7/40 ,  G06T7/149 ,  G06F18/214 ,  G06F18/231 ,  G06F18/2411

CPC分类号： G06T7/12 ,  A61B5/201 ,  A61B5/7267 ,  G06F18/214 ,  G06F18/231 ,  G06F18/2411 ,  G06T7/0012 ,  G06T7/13 ,  G06T7/149 ,  G06T7/155 ,  G06T7/40 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10132 ,  G06T2207/10136 ,  G06T2207/20116 ,  G06T2207/30084

摘要： Described is a method for segmenting an anatomical part, including identifying a landmark on a contour/surface of a 2D/3D model of the anatomical part in an ultrasound image, assigning a weight to the landmark, identifying different appearance patterns of a region around the landmark based on a previously stored training set; and applying a filter to the different appearance patterns of the region around the landmark in order to identify contours of the anatomical part.

公开(公告)号：US20240000936A1

公开(公告)日：2024-01-04

申请号：US18310649

申请日：2023-05-02

申请人： Children's National Medical Center ,  Fred Hutchinson Cancer Center

发明人： Catherine Mary Bollard ,  Danielle Sohai ,  Conrad Russell Y. Cruz ,  Thomas Uldrick

IPC分类号： A61K39/00 ,  C12N5/0783 ,  A61P31/22 ,  A61P35/00

CPC分类号： A61K39/4611 ,  C12N5/0636 ,  A61K39/464838 ,  A61P31/22 ,  A61P35/00 ,  A61K39/464449 ,  A61K39/46444 ,  A61K39/464402 ,  A61K39/464452 ,  C12N2502/1121 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  A61K2239/57 ,  A61K2239/26

摘要： The invention described herein provide Kaposi Sarcoma-Associated Herpesvirus (KSHV) oncoprotein antigens and epitopes for expanding antigen-specific T cells. Such expanded T cells are useful for, e.g., in allogeneic or “off-the-shelf” adoptive T cell therapy.

公开(公告)号：US11669970B2

公开(公告)日：2023-06-06

申请号：US16500875

申请日：2018-04-09

申请人： Children's National Medical Center

发明人： Marius George Linguraru ,  Emily S. Blum ,  Antonio Reyes Porras Perez ,  Hans G. Pohl

IPC分类号： G06T7/00 ,  G16H30/40 ,  A61B6/00 ,  G06F18/214 ,  G06F18/241 ,  G06F18/21 ,  G06F18/2411 ,  A61B5/20 ,  G06V10/764

CPC分类号： G06T7/0016 ,  A61B6/4057 ,  A61B6/50 ,  A61B6/5217 ,  G06F18/214 ,  G06F18/2193 ,  G06F18/241 ,  G06F18/2411 ,  G06V10/764 ,  G16H30/40 ,  A61B5/201 ,  A61B6/5247 ,  A61B2503/045 ,  G06T2207/20056 ,  G06T2207/20064 ,  G06T2207/30084

摘要： Systems, apparatuses, and methods for diagnosing ureteropelvic junction obstruction. A set of biomarkers may be extracted from each of one or more time-activity curves associated with diuresis renography and/or functional magnetic resonance urography of one or more kidneys of a patient. One or more calculations can be performed based on the set of biomarkers to identify uretero-pelvic junction obstruction and a classification of severity or criticality thereof.

公开(公告)号：US20230002730A1

公开(公告)日：2023-01-05

申请号：US17056714

申请日：2019-05-20

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine Mary Bollard ,  Conrad Russell Y. Cruz ,  Patrick Hanley

IPC分类号： C12N5/0783 ,  A61K35/17 ,  C07K14/47

摘要： Disclosed are compositions of cells, libraries of such cells and methods of making T cell populations for treatment of disorders such as cancer and viral infections. T cell composition comprise cell subpopulations stimulated, in some embodiments, with FRAME, survivin and/or WT1.

公开(公告)号：US20220409716A1

公开(公告)日：2022-12-29

申请号：US17763548

申请日：2020-09-24

申请人： Children's National Medical Center ,  The United States of America, as represented by the Secretary, Dept. of Health and Human Service

发明人： Michael Keller ,  Catherine Mary Bollard ,  Ryo Hanajiri ,  Gelina Sani ,  Lisbeth Kim Green ,  Jeff Cohen ,  Stanislav V. Sosnovtsev

IPC分类号： A61K39/12 ,  A61P31/14

摘要： The present disclosure provides adoptive T-cell compositions, therapies, and processes of manufacture that are tailored for treatment or prevention of a subject with a norovirus infection, and, in some embodiments, for those subjects who are candidates for hematopoietic stem cell treatments, subjects who have undergone hematopoietic stem cell treatments, and subjects that have, are diagnosed with or suspected of having primary immunodeficiency disorders.

公开(公告)号：US11518995B2

公开(公告)日：2022-12-06

申请号：US16649122

申请日：2018-09-19

申请人： Children's National Medical Center ,  The Governors of the University of Alberta

发明人： Yi-wen Chen ,  Toshifumi Yokota ,  Rika Yokota-Maruyama ,  Yusuke Echigoya

IPC分类号： C12N15/11 ,  C12N15/113

摘要： The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid (LNA) domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.

公开(公告)号：US20220257606A1

公开(公告)日：2022-08-18

申请号：US17627203

申请日：2020-07-16

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Jyoti JAISWAL ,  Marshall HOGARTH

IPC分类号： A61K31/5415 ,  A61K45/06 ,  A61P21/00

摘要： Disclosed herein are compositions that inhibit adipogenesis of a fibro/adipogenic precursor (FAP) cell and methods relating to treating, preventing, reducing, and/or inhibiting a muscular degenerative condition a muscular degenerative condition comprising administering said inhibitors.