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1.发明授权公开(公告)号：US08278499B2
公开(公告)日：2012-10-02
申请号：US12308758
申请日：2007-06-13
IPC分类号： A01K67/00 , A01K67/027 , G01N33/00
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/035 , A01K2267/0362 , G01N33/5088
摘要： Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.
摘要翻译： 公开了一种非人动物，其显示人类非酒精性脂肪性肝炎的症状，其通过将人肝细胞移植到免疫缺陷型肝病非人类动物中以产生嵌合非人动物，然后将在嵌合非人动物体内繁殖的人肝细胞移植到免疫缺陷 与上述免疫缺陷性肝病非人类动物相同物种的肝病非人类动物，以及显示通过将人肝细胞移植到免疫缺陷型肝病非人类动物中以产生嵌合非人动物而获得的人类脂肪肝症状的非人动物。
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公开(公告)号：US07871980B2
公开(公告)日：2011-01-18
申请号：US11988028
申请日：2006-06-30
申请人： Chise Mukaidani , Katsutoshi Yoshizato , Norio Masumoto , Miho Kataoka , Tatsuhiko Tsunoda , Fuyuki Miya
发明人： Chise Mukaidani , Katsutoshi Yoshizato , Norio Masumoto , Miho Kataoka , Tatsuhiko Tsunoda , Fuyuki Miya
CPC分类号： A61K38/27 , A01K67/0271 , A01K67/0275 , A01K2227/105 , A01K2267/03 , A61K35/407 , C12N9/6424
摘要： Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.
摘要翻译： 将人成年肝细胞移植到免疫缺陷型肝病小鼠中，然后向小鼠施用人生长激素，从而通过移植的人成年肝细胞提升两倍以上的置换率。 此外，将人生长激素施用于携带人类年轻肝细胞的免疫缺陷型肝病小鼠，以改善其中约70％或更多的肝细胞已被人肝细胞代替的小鼠的脂肪肝。
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3.发明申请公开(公告)号：US20090313710A1
公开(公告)日：2009-12-17
申请号：US12308758
申请日：2007-06-13
IPC分类号： G01N33/576 , A01K67/027 , C12N15/00
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/035 , A01K2267/0362 , G01N33/5088
摘要： Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.
摘要翻译： 公开了一种非人动物，其显示人类非酒精性脂肪性肝炎的症状，其通过将人肝细胞移植到免疫缺陷型肝病非人类动物中以产生嵌合非人动物，然后将在嵌合非人动物体内繁殖的人肝细胞移植到免疫缺陷 与上述免疫缺陷性肝病非人类动物相同物种的肝病非人类动物，以及显示通过将人肝细胞移植到免疫缺陷型肝病非人类动物中以产生嵌合非人动物而获得的人类脂肪肝症状的非人动物。
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公开(公告)号：US20090060882A1
公开(公告)日：2009-03-05
申请号：US11988028
申请日：2006-06-30
申请人： Chise Mukaidani , Katsutoshi Yoshizato , Norio Masumoto , Miho Kataoka , Tatsuhiko Tsunoda , Fuyuki Miya
发明人： Chise Mukaidani , Katsutoshi Yoshizato , Norio Masumoto , Miho Kataoka , Tatsuhiko Tsunoda , Fuyuki Miya
CPC分类号： A61K38/27 , A01K67/0271 , A01K67/0275 , A01K2227/105 , A01K2267/03 , A61K35/407 , C12N9/6424
摘要： Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.
摘要翻译： 将人成年肝细胞移植到免疫缺陷型肝病小鼠中，然后向小鼠施用人生长激素，从而通过移植的人成年肝细胞提升两倍以上的置换率。 此外，将人生长激素施用于携带人类年轻肝细胞的免疫缺陷型肝病小鼠，以改善其中约70％或更多的肝细胞已被人肝细胞代替的小鼠的脂肪肝。
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