公开(公告)号：US20140220617A1

公开(公告)日：2014-08-07

申请号：US14007738

申请日：2012-04-02

申请人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

发明人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

IPC分类号： C12Q1/04 ,  B03C1/00 ,  B01L3/00

CPC分类号： C12Q1/04 ,  A61M1/36 ,  A61M1/3618 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/56 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/043 ,  B01L2400/0487 ,  B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26

摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

摘要翻译： 提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。 通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。 流体可以通过通道以高流速流动。 源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括收集流体以将目标组分冲洗出收集通道。 随后分析目标成分进行检测和诊断。 微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。 因此，通过组合流体学和磁性，该装置作为透析像治疗装置。