公开(公告)号：US20060008800A1

公开(公告)日：2006-01-12

申请号：US10495083

申请日：2002-10-29

申请人： Christian Rosenmund ,  Nils Brose ,  Jeong-Seon Rhee ,  Andrea Betz ,  Jens Rettig ,  Uri Ashery ,  Harald Junge

发明人： Christian Rosenmund ,  Nils Brose ,  Jeong-Seon Rhee ,  Andrea Betz ,  Jens Rettig ,  Uri Ashery ,  Harald Junge

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/02

CPC分类号： C07K14/705 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6872 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/042

摘要： The present invention relates to a method for identifying and/or obtaining a molecule which is capable of modifying secretion processes comprising the steps of a) contacting an unc-13 molecule or (a) part(s) or (a) fragment(s) thereof with a candidate molecule; b) measuring and/or detecting a response; and c) comparing said response to a standard response as measured in the absence of said candidate molecule. Furthermore, a method for identifying and/or obtaining a isoform-specific modulator of isoform-specific Munc13 activity is disclosed. The invention also provides for pharmaceutical and diagnostic compositions as well as for uses of antagonist or agonists as identified and/or obtained by the inventive method for the preparation of pharmaceutical and diagnostic compositions.

摘要翻译： 本发明涉及一种用于鉴定和/或获得能够改变分泌过程的分子的方法，包括以下步骤：a）使unc-13分子或（a）部分或（a） 与候选分子; b）测量和/或检测响应; 和c）将所述应答与在不存在所述候选分子的情况下测量的标准反应进行比较。 此外，公开了用于鉴定和/或获得同种型特异性Munc13活性的同种型特异性调节剂的方法。 本发明还提供药物和诊断组合物以及通过本发明方法鉴定和/或获得的用于制备药物和诊断组合物的拮抗剂或激动剂的用途。