公开(公告)号：US06403561B1

公开(公告)日：2002-06-11

申请号：US08930055

申请日：1998-02-19

申请人： Christiane Rose ,  Froylan Vargas ,  Pierre Bourgeat ,  Jean-Charles Schwartz ,  Paul Beaumont Bishop ,  Ramesh B. Bambal ,  Charon Robin Ganellin ,  Bertrand Leblond ,  Andrew N. J. Moore ,  Lihua Zhao ,  Suzanne Chan

发明人： Christiane Rose ,  Froylan Vargas ,  Pierre Bourgeat ,  Jean-Charles Schwartz ,  Paul Beaumont Bishop ,  Ramesh B. Bambal ,  Charon Robin Ganellin ,  Bertrand Leblond ,  Andrew N. J. Moore ,  Lihua Zhao ,  Suzanne Chan

IPC分类号： C07K5062

CPC分类号： C07K5/06052 ,  A61K38/00 ,  C07D209/42 ,  C07K5/06026 ,  C07K5/06191 ,  C12Q1/37 ,  G01N2333/595

摘要： A compound of formula wherein the substituents are defined as in the specification and salts or hydrates thereof is disclosed as well as a method of treating disorders associated with the inactivation or excessive degradation of cholecystokinin.

摘要翻译： 所述取代基的化合物如本说明书中所定义，其盐或其水合物也被公开，以及治疗与缩胆囊素的失活或过度降解有关的病症的方法。

公开(公告)号：US20060084792A1

公开(公告)日：2006-04-20

申请号：US11194991

申请日：2005-08-01

申请人： Chad Paavola ,  Jonathan Trent ,  Suzanne Chan ,  Yi-Fen Li ,  R. McMillan ,  Hiromi Kagawa

发明人： Chad Paavola ,  Jonathan Trent ,  Suzanne Chan ,  Yi-Fen Li ,  R. McMillan ,  Hiromi Kagawa

IPC分类号： C07K14/195 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C12N1/21

CPC分类号： C07K14/47 ,  B82Y30/00

摘要： The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the folded modified chaperonin polypeptide. In the modified chaperonin polypeptide, the naturally-occurring N-terminal and C-terminal ends are joined together directly or with an intervening linker peptide sequence. The relocated N-terminal or C-terminal ends can be covalently joined to, or bound with another molecule such as a nucleic acid molecule, a lipid, a carbohydrate, a second polypeptide, or a nanoparticle. The modified chaperonin polypeptides can assemble into double-ringed chaperonin structures. Further, the chaperonin structures can organize into higher order structures such as nanofilaments or nanoarrays which can be used to produce nanodevices and nanocoatings.

摘要翻译： 本发明提供了伴侣伴侣多肽，其被修饰为包括从位于折叠的修饰的伴侣蛋白多肽的外部的多肽中的中心孔区域重新定位到各种不同位置的N末端和C末端。 在修饰的伴侣蛋白多肽中，天然存在的N-末端和C-末端直接连接在一起或与插入的接头肽序列连接在一起。 重新定位的N-末端或C-末端可共价连接至另一分子例如核酸分子，脂质，碳水化合物，第二多肽或纳米颗粒。 修饰的伴侣蛋白多肽可以组装成双环伴侣蛋白结构。 此外，伴侣蛋白结构可以组织成更高级的结构，例如可用于制备纳米装置和纳米涂层的纳米丝或纳米阵列。