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公开(公告)号:US20090304713A1
公开(公告)日:2009-12-10
申请号:US12276889
申请日:2008-11-24
申请人: Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
发明人: Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
IPC分类号: A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K7/06 , C07K7/08 , C07K19/00 , C07K14/76 , C07K14/79
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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公开(公告)号:US07592429B2
公开(公告)日:2009-09-22
申请号:US11411003
申请日:2006-04-25
申请人: Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
发明人: Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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公开(公告)号:US08003108B2
公开(公告)日:2011-08-23
申请号:US11410540
申请日:2006-04-25
申请人: Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
发明人: Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
CPC分类号: C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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4.
公开(公告)号:US20110262443A1
公开(公告)日:2011-10-27
申请号:US12989373
申请日:2009-04-22
IPC分类号: A61K39/395 , C07K16/24 , C07K14/54
CPC分类号: C07K16/244 , C07K14/54 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要: The present invention relates neutralising epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.
摘要翻译: 本发明涉及IL-17A和IL-17F的中和表位和与这些表位结合的抗体。 本发明还涉及抗体分子的治疗用途及其制备方法。
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公开(公告)号:US08679494B2
公开(公告)日:2014-03-25
申请号:US12989373
申请日:2009-04-22
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , C07K14/54 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要: The present invention relates neutralising epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.
摘要翻译: 本发明涉及IL-17A和IL-17F的中和表位和与这些表位结合的抗体。 本发明还涉及抗体分子的治疗用途及其制备方法。
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