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公开(公告)号：US20090304713A1
公开(公告)日：2009-12-10
申请号：US12276889
申请日：2008-11-24
申请人： Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
发明人： Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K7/06 , C07K7/08 , C07K19/00 , C07K14/76 , C07K14/79
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US07592429B2
公开(公告)日：2009-09-22
申请号：US11411003
申请日：2006-04-25
申请人： Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
发明人： Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20070009508A1
公开(公告)日：2007-01-11
申请号：US10568377
申请日：2004-08-12
申请人： Alastair Lawson , Meryn Griffiths
发明人： Alastair Lawson , Meryn Griffiths
IPC分类号： A61K39/395 , G01N33/567 , G01N33/53 , C07K16/28
CPC分类号： G01N33/6854 , C07K16/243 , C07K16/245 , C07K2317/73 , G01N33/54326 , G01N33/56972 , G01N33/582
摘要： The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen.
摘要翻译： 本发明涉及一种富集产生识别感兴趣的抗原的抗体的那些细胞中的细胞群的方法。 特别地，未标记的抗原与多克隆抗体结合使用以分离识别所述抗原的细胞。
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公开(公告)号：US08003108B2
公开(公告)日：2011-08-23
申请号：US11410540
申请日：2006-04-25
申请人： Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
发明人： Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20070110747A1
公开(公告)日：2007-05-17
申请号：US11411003
申请日：2006-04-25
申请人： Christopher Paszty , Martyn Robinson , Kevin Graham , Alistair Henry , Kelly Hoffmann , John Latham , Hsieng Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron Winters
发明人： Christopher Paszty , Martyn Robinson , Kevin Graham , Alistair Henry , Kelly Hoffmann , John Latham , Hsieng Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron Winters
IPC分类号： A61K39/395 , G01N33/567 , C07K16/18
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20110305702A1
公开(公告)日：2011-12-15
申请号：US13096263
申请日：2011-04-28
申请人： HSIENG S. LU , CHRISTOPHER J. PASZTY , MARTYN KIM ROBINSON , ALISTAIR J. HENRY , KELLY SUE WARMINGTON , JOHN LATHAM , ALASTAIR LAWSON , DAVID G. WINKLER , AARON GEORGE WINTERS
发明人： HSIENG S. LU , CHRISTOPHER J. PASZTY , MARTYN KIM ROBINSON , ALISTAIR J. HENRY , KELLY SUE WARMINGTON , JOHN LATHAM , ALASTAIR LAWSON , DAVID G. WINKLER , AARON GEORGE WINTERS
IPC分类号： A61K39/395 , A61P19/10 , A61P19/00 , C07K16/18 , C12N15/13
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20110097342A1
公开(公告)日：2011-04-28
申请号：US12950094
申请日：2010-11-19
申请人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
发明人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , C07K7/06 , C07K7/08 , A61P19/08 , A61P19/10
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20070243564A1
公开(公告)日：2007-10-18
申请号：US11628809
申请日：2005-06-10
申请人： Alastair Lawson , Simon Tickle
发明人： Alastair Lawson , Simon Tickle
CPC分类号： G01N33/56972 , C07K16/00 , G01N33/6854 , G01N33/6857
摘要： The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.
摘要翻译： 本发明提供了用于鉴定产生抗体的抗体产生细胞的自动均质测定法，所述抗体结合所选择的抗原，特别是高产抗体产生细胞。
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公开(公告)号：US20070072797A1
公开(公告)日：2007-03-29
申请号：US11410540
申请日：2006-04-25
申请人： Martyn Robinson , Alistair Henry , Alastair Lawson , Hsieng Lu , Christopher Paszty , Kelly Hoffmann , John Latham , David Winkler , Aaron Winters
发明人： Martyn Robinson , Alistair Henry , Alastair Lawson , Hsieng Lu , Christopher Paszty , Kelly Hoffmann , John Latham , David Winkler , Aaron Winters
IPC分类号： A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20060263353A1
公开(公告)日：2006-11-23
申请号：US10568246
申请日：2004-08-12
申请人： Alastair Lawson , Meryn Griffiths
发明人： Alastair Lawson , Meryn Griffiths
IPC分类号： A61K39/395 , G01N33/567 , C07H21/04 , C12P21/06 , C07K16/18
CPC分类号： G01N33/582 , G01N33/56972
摘要： The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen.
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