公开(公告)号：US20080249466A1

公开(公告)日：2008-10-09

申请号：US11720538

申请日：2005-12-01

申请人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud ,  Grant Timothy Lewis Smetham ,  Julian Richard Dixon ,  Matthew Egerton Young

发明人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud ,  Grant Timothy Lewis Smetham ,  Julian Richard Dixon ,  Matthew Egerton Young

IPC分类号： A61M5/00

CPC分类号： A61M37/0069 ,  A61M31/007

摘要： The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elastic return of the secondary body (12) from the main body (10).

摘要翻译： 本发明涉及一种用于将植入物（30）背面注射到受试者的皮肤（22）中的装置，所述装置（1）包括中空主体（10），中空针（28）被固定到其中， 引入植入物（30），同轴地布置在主体（10）内部并围绕针（28）的次体（12; 114）和能够同轴地在所述中空针（28）内滑动的活塞杆（88）和 当背部注射装置（1）被压靠在被检者的皮肤（22）上时，相对于所述针（28）的位置保持不变，以允许针（28）穿透所述被检者的皮肤，并且当二次体（12）向内缩回时 所述主体（10），所述活塞杆（88）穿过所述中空针（28）的内部，以在所述中空针（28）的取出期间将所述植入物（30）保持在所述受试者皮肤（22）中所需的深度处， 从主体的皮肤（22）离开第二主体（12; 114） 主体（10），其特征在于，其包括用于从主体（10）弹性返回次体（12）的装置。

公开(公告)号：US07798988B2

公开(公告)日：2010-09-21

申请号：US11720538

申请日：2005-12-01

申请人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud ,  Grant Timothy Lewis Smetham ,  Julian Richard Dixon ,  Matthew Egerton Young

发明人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud ,  Grant Timothy Lewis Smetham ,  Julian Richard Dixon ,  Matthew Egerton Young

IPC分类号： A61M31/00

CPC分类号： A61M37/0069 ,  A61M31/007

摘要： The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elastic return of the secondary body (12) from the main body (10).

摘要翻译： 本发明涉及一种用于将植入物（30）背面注射到受试者的皮肤（22）中的装置，所述装置（1）包括中空主体（10），中空针（28）被固定到其中， 引入植入物（30），同轴地布置在主体（10）内部并围绕针（28）的次体（12; 114）和能够同轴地在所述中空针（28）内滑动的活塞杆（88）和 当背部注射装置（1）被压靠在被检者的皮肤（22）上时，相对于所述针（28）的位置保持不变，以允许针（28）穿透所述被检者的皮肤，并且当二次体（12）向内缩回时 所述主体（10），所述活塞杆（88）穿过所述中空针（28）的内部，以在所述中空针（28）的取出期间将所述植入物（30）保持在所述受试者皮肤（22）中所需的深度处， 从主体的皮肤（22）中，次体（12; 114）离开主体（10），其特征在于，其包括 用于使主体（12）从主体（10）弹性返回的装置。

公开(公告)号：US08348881B2

公开(公告)日：2013-01-08

申请号：US11720534

申请日：2005-11-15

申请人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

发明人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

IPC分类号： A61M31/00

CPC分类号： A61M37/00 ,  A61M37/0069

摘要： The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

摘要翻译： 本发明涉及一种用于注射固体药物（10）的装置，该固体药物（10）包括主体（2），其内部沿着总体向前移动轴线（XX）移动，其中引入药物（10）的斜头（34）针（4） 注射装置（1）还包括用于防止药物在注射之前落下（10）的保持装置。 本发明的特征在于，药物（10）通过保持装置赋予针（4）的弹性变形或通过保持装置本身的弹性变形或者仍然通过这两种装置的组合柔性来保持。

公开(公告)号：US08029458B2

公开(公告)日：2011-10-04

申请号：US11720542

申请日：2005-11-15

申请人： Roland Cherif-Cheikh ,  Christophe Aubert ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

发明人： Roland Cherif-Cheikh ,  Christophe Aubert ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

IPC分类号： A61B17/20

CPC分类号： A61M37/0069

摘要： The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises: a main hollow body (2; 2′) having a hollow needle (4; 4′) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26′) which is disposed coaxially inside the main body (2; 2′) and which surrounds the needle (4; 4′); and a plunger rod (36; 36′) which can slide coaxially inside the hollow needle (4; 4′). The injection device (1; 1′) is arranged such that: (i) when it is pressed against the tissues (50), the main body (2; 2′) slides along the length of the secondary body (26; 26′) from a proximal position to a distal position such that the needle (4; 4′) can penetrate the tissues (50), whereby the movement of the main body (1; 1′) is accompanied by the concomitant movement of the plunger rod (36; 36′); and (ii) the plunger rod (36; 36′) remains fixed and maintains the implant (6) at the required depth in the tissues (50) until the needle (4; 4′) is removed therefrom when the main body (2; 2′) is returned from the distal position to the proximal position.

摘要翻译： 本发明涉及一种用于将植入物（6）注射到组织（50）中的装置。 本发明的装置的特征在于它包括：主空心体（2; 2'），其具有固定到其上的中空针（4; 4'），植入物（6）被引入其中; 主体（26; 26'），其同轴地设置在主体（2; 2'）内并且围绕针（4; 4'）; 以及可以在中空针（4; 4'）内同轴滑动的柱塞杆（36; 36'）。 注射装置（1; 1'）布置成：（i）当其被压靠在组织（50）上时，主体（2; 2'）沿着次体（26; 26'）的长度滑动， ）从近端位置到远端位置，使得针（4; 4'）能够穿透组织（50），由此主体（1; 1'）的移动伴随着柱塞杆 （36; 36'）; 并且（ii）柱塞杆（36; 36'）保持固定并将植入物（6）保持在组织（50）中所需的深度，直到当主体（2） ; 2'）从远端位置返回到近端位置。

公开(公告)号：US20090270797A1

公开(公告)日：2009-10-29

申请号：US11720534

申请日：2005-11-15

申请人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

发明人： Christophe Aubert ,  Roland Cherif-Cheikh ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

IPC分类号： A61M5/31

CPC分类号： A61M37/00 ,  A61M37/0069

摘要： The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

摘要翻译： 本发明涉及一种用于注射固体药物（10）的装置，该固体药物（10）包括主体（2），其内部沿着总体向前移动轴线（XX）移动，其中引入药物（10）的斜头（34）针（4） 注射装置（1）还包括用于防止药物在注射之前落下（10）的保持装置。 本发明的特征在于，药物（10）通过保持装置赋予针（4）的弹性变形或通过保持装置本身的弹性变形或者仍然通过这两种装置的组合柔性来保持。

公开(公告)号：US20090209903A1

公开(公告)日：2009-08-20

申请号：US11720542

申请日：2005-11-15

申请人： Roland Cherif-Cheikh ,  Christophe Aubert ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

发明人： Roland Cherif-Cheikh ,  Christophe Aubert ,  Thierry Rimlinger ,  Fabrice Bonacci ,  Serge Barneaud

IPC分类号： A61M5/32

CPC分类号： A61M37/0069

摘要： The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises : a main hollow body (2; 2′) having a hollow needle (4; 4′) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26′) which is disposed coaxially inside the main body (2; 2′) and which surrounds the needle (4; 4′); and a plunger rod (36; 36′) which can slide coaxially inside the hollow needle (4; 4′). The injection device (1; 1′) is arranged such that: (i) when it is pressed against the tissues (50), the main body (2; 2′) slides along the length of the secondary body (26; 26′) from a proximal position to a distal position such that the needle (4; 4′) can penetrate the tissues (50), whereby the movement of the main body (1; 1′) is accompanied by the concomitant movement of the plunger rod (36; 36′); and (ii) the plunger rod (36; 36′) remains fixed and maintains the implant (6) at the required depth in the tissues (50) until the needle (4; 4′) is removed therefrom when the main body (2; 2′) is returned from the distal position to the proximal position.

摘要翻译： 本发明涉及一种用于将植入物（6）注射到组织（50）中的装置。 本发明的装置的特征在于它包括：主空心体（2; 2'），其具有固定到其上的中空针（4; 4'），植入物（6）被引入其中; 主体（26; 26'），其同轴地设置在主体（2; 2'）内并且围绕针（4; 4'）; 以及可以在中空针（4; 4'）内同轴滑动的柱塞杆（36; 36'）。 注射装置（1; 1'）布置成：（i）当其被压靠在组织（50）上时，主体（2; 2'）沿着次体（26; 26'）的长度滑动， ）从近端位置到远端位置，使得针（4; 4'）能够穿透组织（50），由此主体（1; 1'）的移动伴随着柱塞杆 （36; 36'）; 并且（ii）柱塞杆（36; 36'）保持固定并将植入物（6）保持在组织（50）中所需的深度，直到当主体（2） ; 2'）从远端位置返回到近端位置。

公开(公告)号：US06953447B2

公开(公告)日：2005-10-11

申请号：US10278163

申请日：2002-10-22

申请人： Christophe Aubert ,  Roland Cherif-Cheikh

发明人： Christophe Aubert ,  Roland Cherif-Cheikh

IPC分类号： A61M5/315 ,  A61M5/32 ,  A61M5/00 ,  B65D83/10

CPC分类号： A61M5/315 ,  A61M5/3205 ,  Y10S128/919

摘要： The invention relates to a pre-filled injection device for injecting a liquid or semisolid composition into a subject, said injection device comprising: a housing (1) containing at its distal end the liquid or semisolid composition (2), a plunger (3) arranged to slide within the housing (1) to which is affixed a plunger stick (7) extending longitudinally from the plunger to the outside of the housing (1), a hollow needle (4) affixed to the distal end of the housing (1), said needle (4) connecting the interior part of the housing (1) with the outside where it extends longitudinally, and an airtight needle shield (5) which protects said needle (4), characterized in that said device further comprises a cap (6) designed to fit around the housing's proximal end and to fully cover said plunger stick (7), said cap (6) both preventing its accidental pushing or breakage before use and being adapted to receive the injection device once the injection into the subject has been carried out.

摘要翻译： 本发明涉及一种用于将液体或半固体组合物注射到受试者中的预填充注射装置，所述注射装置包括：在其远端包含液体或半固体组合物（2）的壳体（1），柱塞（3） 布置成在所述壳体（1）内滑动，所述壳体（1）固定有从所述柱塞纵向延伸到所述壳体（1）的外部的柱塞杆（7），固定到所述壳体（1）的远端的中空针 ），所述针（4）将所述壳体（1）的内部与其纵向延伸的外部连接，以及保护所述针（4）的气密针护罩（5），其特征在于，所述装置还包括帽 （6），其被设计成围绕所述壳体的近端并且完全覆盖所述柱塞杆（7），所述盖（6）在使用之前都防止其意外推动或破裂，并且一旦注入到所述对象中就适于接收所述注射装置 已经开展

公开(公告)号：US20050075602A1

公开(公告)日：2005-04-07

申请号：US10969833

申请日：2004-10-21

申请人： Roland Cherif-Cheikh ,  Christophe Aubert

发明人： Roland Cherif-Cheikh ,  Christophe Aubert

IPC分类号： A61J3/00 ,  A61J1/20 ,  A61M5/24 ,  A61M5/28 ,  A61M5/315 ,  A61M5/32 ,  A61M37/00

CPC分类号： A61M5/3202 ,  A61M5/2448 ,  A61M5/288 ,  A61M5/31596 ,  A61M2005/2451 ,  A61M2005/247 ,  A61M2005/31598

摘要： A packaging process inside a cylindrical reservoir (13) selected on one side by an injection piston (29) locked in its movement in said reservoir (13), comprising the elements to be packed (14) into the inside of said reservoir (13) from said injection piston (29) before said reservoir (13) is sealed by said piston (29), said reservoir (13) being tube or a cartridge (13) sealed beforehand from the other side and introducing the cylindrical reservoir (13) beforehand into a support (19) and said piston (29) locked in another support (19), thus allowing an opening to the outside of said reservoir between the two supports (19); introducing the piston (29) into said reservoir (13) by pressure and by a bringing together of said two supports (19).

摘要翻译： 在一个圆柱形容器（13）内的包装工艺，其中一个侧面上被锁定在所述储存器（13）中的注射活塞（29）选择，包括待包装的元件（14）进入所述储存器（13）的内部， 在所述储存器（13）被所述活塞（29）密封之前，所述储存器（13）是从所述注射活塞（29）开始的，所述储存器（13）是预先从另一侧密封并且预先引入所述圆柱形储存器（13）的管（13） 支撑件（19）和所述活塞（29）锁定在另一支撑件（19）中，从而允许在两个支撑件（19）之间的所述储存器的外部开口; 通过压力将活塞（29）引入所述储存器（13）中并通过将所述两个支撑件（19）汇合在一起。

公开(公告)号：US06902543B1

公开(公告)日：2005-06-07

申请号：US10110362

申请日：2000-10-10

申请人： Roland Cherif-Cheikh ,  Christophe Aubert

发明人： Roland Cherif-Cheikh ,  Christophe Aubert

IPC分类号： A61J3/00 ,  A61J1/20 ,  A61M5/24 ,  A61M5/28 ,  A61M5/315 ,  A61M5/32 ,  A61M37/00

CPC分类号： A61M5/3202 ,  A61M5/2448 ,  A61M5/288 ,  A61M5/31596 ,  A61M2005/2451 ,  A61M2005/31598

摘要： The invention relates to a syringe-type device for freshly preparing a solution, suspension or dispersion, for example injectable formulations, preferably according to a method for reconstitution in a vacuum. The device is shown in FIG. 1. The invention also relates to a method for packing the fresh preparation of the solution, suspension or dispersion in a cylindrical reservoir that can be used in a single or multi-dose syringe provided for the same. This is a method for packing the preparation inside the cylindrical reservoir, which is closed on one side by an injection plunger whose movement in the reservoir is limited. This method is characterised in that the elements to be packed are introduced into the reservoir from the injection plunger side before the reservoir is closed by said plunger. Said reservoir is a tube or ampule which is closed on the other side in advance.

摘要翻译： 本发明涉及一种用于新鲜制备溶液，悬浮液或分散体（例如可注射制剂）的注射器型装置，优选根据在真空中重构的方法。 该装置如图1所示。 1。 本发明还涉及一种用于将溶液，悬浮液或分散体的新鲜制剂包装在圆柱形容器中的方法，该方法可用于为其提供的单剂量或多剂量注射器。 这是一种用于将制剂包装在圆柱形储存器内的方法，其通过注射柱塞在一侧封闭，注射柱塞在储存器中的运动受到限制。 该方法的特征在于，在储存器被所述柱塞关闭之前，要被填充的元件从注射柱塞侧引入储存器。 所述储存器是预先在另一侧封闭的管或安瓿。

公开(公告)号：US09382306B2

公开(公告)日：2016-07-05

申请号：US13121928

申请日：2009-09-29

申请人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Franck Artzner

发明人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Franck Artzner

IPC分类号： A61K38/31 ,  A61P5/02 ,  C07K14/655 ,  A61K38/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/665 ,  A61K38/00

CPC分类号： C07K14/665 ,  A61K38/00

摘要： The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal 1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.

摘要翻译： 本发明涉及通式（I）的新型八肽化合物：H-2-萘-1-环（Cys2-Tyr3-AA4-Lys5-Val6-Cys7）-Thr8-NH2。 由于这些产品对某些生长抑素受体亚型具有良好的亲和力，因此它们特别有利于治疗涉及一种（或更多种）生长抑素受体的病理状态或疾病。 这些化合物还具有物理化学性质，使得可以将它们设想为药物制剂的各种溶液，例如药学上可接受的载体。 本发明还涉及含有所述产物的药物组合物及其用于制备药物的用途。