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公开(公告)号：US4273773A
公开(公告)日：1981-06-16
申请号：US78547
申请日：1979-09-24
IPC分类号： C07D487/04 , A61K31/495 , C07D241/36
CPC分类号： C07D487/04
摘要： Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
摘要翻译： 三环异吲哚衍生物的特征在于具有1,2,3,4,6,10b-六氢吡嗪并[2,1-a]异吲哚或1,3,4,10b-四氢嘧啶并[6,1-a]异吲哚-6（2H ） - 核。 上述化合物是有用的抗高血压药。
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公开(公告)号：US4323572A
公开(公告)日：1982-04-06
申请号：US232267
申请日：1981-02-06
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
摘要： Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
摘要翻译： 三环异吲哚衍生物的特征在于具有1,2,3,4,6,10b-六氢吡嗪并[2,1-a]异吲哚或1,3,4,10b-四氢嘧啶并[6,1-a]异吲哚-6（2H ） - 核。 上述化合物是有用的抗高血压药。
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公开(公告)号：US4423232A
公开(公告)日：1983-12-27
申请号：US235814
申请日：1981-02-19
IPC分类号： C07D487/04 , C07D209/46
CPC分类号： C07D487/04
摘要： Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino]2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.Claimed compounds include those of the formula ##STR1## in which R.sup.3 and R.sup.4 each is hydrogen, lower alkoxy, lower alkyl, trifluoromethyl, halo or hydroxy, or R.sup.3 and R.sup.4 together form an OCH.sub.2 O chain; and R.sup.14 and R.sup.15 each is hydrogen or lower alkyl.
摘要翻译： 三环异吲哚衍生物，其特征在于具有1,2,3,4,6,10b-六氢吡嗪并[2,1-a]异吲哚或1,3,4,10b-四氢嘧啶并[6,1-a]异吲哚-6（2H ） - 核。 上述化合物是有用的抗高血压药。 所要求的化合物包括式（Ia）的化合物，其中R 3和R 4各自为氢，低级烷氧基，低级烷基，三氟甲基，卤素或羟基，或者R 3和R 4一起形成OCH 2 O 2链; R 14和R 15各自为氢或低级烷基。
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4.发明授权1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives 失效1,3-二氢-3-（2-羟基 - ，2-溴 - 或2-氯乙基）-2H-异吲哚-1-酮衍生物
公开(公告)号：US4244966A
公开(公告)日：1981-01-13
申请号：US78546
申请日：1979-09-24
IPC分类号： C07C207/04 , C07D209/46 , C07D275/06 , C07D307/88 , A61K31/40
CPC分类号： C07D275/06 , C07C207/04 , C07D209/46 , C07D307/88 , Y10S514/925
摘要： Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.
摘要翻译： 公开了1,3-二氢-3-（2-羟乙基）-2H-异吲哚-1-酮的衍生物。 所述衍生物可用于治疗哺乳动物的溃疡，并且用于预防或减少患有高氯酸盐和/或相关病症的哺乳动物中过量的胃酸或盐酸的分泌或可用性。
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公开(公告)号：US4131745A
公开(公告)日：1978-12-26
申请号：US852656
申请日：1977-11-18
IPC分类号： A61K31/135 , C07C233/16 , C07C103/38
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
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公开(公告)号：US4118511A
公开(公告)日：1978-10-03
申请号：US852657
申请日：1977-11-18
IPC分类号： A61K31/135 , C07C233/16
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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公开(公告)号：US4033974A
公开(公告)日：1977-07-05
申请号：US657118
申请日：1976-02-11
IPC分类号： A61K38/00 , C07D213/30 , C07D213/55
CPC分类号： C07D213/30 , A61K38/00
摘要： Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives are disclosed. The derivatives are characterized by having a phenoxyalkanoyl group and a pyridylmethyloxy group-joined together by a peptide group. They possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use are disclosed.
摘要翻译： 公开了N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯。 该衍生物的特征在于具有通过肽基团连接在一起的苯氧基烷酰基和吡啶基甲氧基。 它们具有抗高脂蛋白血症活性。 另外，公开了其制备和使用的方法。
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8.发明授权
公开(公告)号：US4170653A
公开(公告)日：1979-10-09
申请号：US829769
申请日：1977-09-01
IPC分类号： C07D295/092 , C07D295/13 , A61K31/445 , C07D211/14
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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公开(公告)号：US4071552A
公开(公告)日：1978-01-31
申请号：US687852
申请日：1976-05-19
IPC分类号： A61K31/135 , C07C233/16 , C07C91/16 , C07C93/18
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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10.发明授权Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives for therepeutic use 失效N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯用于该方法
公开(公告)号：US3956484A
公开(公告)日：1976-05-11
申请号：US505103
申请日：1974-09-11
IPC分类号： A61K38/00 , C07D213/30 , C07K5/06 , A61K31/44 , A61K37/00
CPC分类号： C07D213/30 , C07K5/06191 , A61K38/00
摘要： Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives are disclosed. The derivatives are characterized by having a phenoxyalkanoyl group and a pyridylmethyloxy group-joined together by a peptide group. They possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use are disclosed.
摘要翻译： 公开了N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯。 该衍生物的特征在于具有通过肽基团连接在一起的苯氧基烷酰基和吡啶基甲氧基。 它们具有抗高脂蛋白血症活性。 另外，公开了其制备和使用的方法。
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