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公开(公告)号:US08013001B2
公开(公告)日:2011-09-06
申请号:US12337591
申请日:2008-12-17
申请人: Christopher D. Bayne , Alan T. Johnson , Shao Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, Jr. , Haixia Wang , Yinong Xie
发明人: Christopher D. Bayne , Alan T. Johnson , Shao Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, Jr. , Haixia Wang , Yinong Xie
IPC分类号: A61K31/4412 , C07D213/64
CPC分类号: C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要: Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式(I)的化合物:其中n,m,A,B,R 1,R 2,R 3,R 4和R 5在本文中定义,可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号:US20100056582A1
公开(公告)日:2010-03-04
申请号:US12337591
申请日:2008-12-17
申请人: Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, JR. , Haixia Wang , Yinong Xie
发明人: Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, JR. , Haixia Wang , Yinong Xie
IPC分类号: A61K31/4439 , C07D213/63 , C07D401/04 , A61K31/44
CPC分类号: C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要: Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式(I)的化合物:其中n,m,A,B,R 1,R 2,R 3,R 4和R 5在本文中定义,可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号:US20080119488A1
公开(公告)日:2008-05-22
申请号:US11572579
申请日:2005-07-24
申请人: Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
发明人: Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
IPC分类号: A61K31/497 , C07D211/98 , A61K31/4418 , C07D401/12 , A61K31/513 , C07D401/04 , A61K31/443 , A61P3/00 , A61P25/00 , C12N5/06 , C07K14/00 , A61P9/00 , A61P17/10 , A61K31/4433 , C07D401/14 , A61K31/4439 , A61K31/4545 , C07D409/04 , A61K31/4436
CPC分类号: C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要: Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式(I)化合物,其中n,m,A,R 1,R 2,R 3,R 4和R 5在本文中定义,可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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4.
公开(公告)号:US20080132521A1
公开(公告)日:2008-06-05
申请号:US11829324
申请日:2007-07-27
申请人: Alan T. Johnson , Satoru Kaneko , Raju Mohan , Kozo Oda , Edwin J. Schweiger
发明人: Alan T. Johnson , Satoru Kaneko , Raju Mohan , Kozo Oda , Edwin J. Schweiger
IPC分类号: A61K31/497 , C07D217/24 , A61K31/472 , A61P9/00 , A61P9/10 , C07D401/02
CPC分类号: C07D405/04 , C07D217/24 , C07D409/04
摘要: Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.
摘要翻译: 式(I)化合物:其中n,R 1,R 2,R 3和R 7均为 本文公开的这些文献可用于治疗与核受体活性相关的疾病状态。 包含的药物组合物和使用所述化合物的方法也在本文中公开。
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