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公开(公告)号：US08013001B2
公开(公告)日：2011-09-06
申请号：US12337591
申请日：2008-12-17
申请人： Christopher D. Bayne , Alan T. Johnson , Shao Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, Jr. , Haixia Wang , Yinong Xie
发明人： Christopher D. Bayne , Alan T. Johnson , Shao Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, Jr. , Haixia Wang , Yinong Xie
IPC分类号： A61K31/4412 , C07D213/64
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式（I）的化合物：其中n，m，A，B，R 1，R 2，R 3，R 4和R 5在本文中定义，可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US20100056582A1
公开(公告)日：2010-03-04
申请号：US12337591
申请日：2008-12-17
申请人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, JR. , Haixia Wang , Yinong Xie
发明人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens, JR. , Haixia Wang , Yinong Xie
IPC分类号： A61K31/4439 , C07D213/63 , C07D401/04 , A61K31/44
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式（I）的化合物：其中n，m，A，B，R 1，R 2，R 3，R 4和R 5在本文中定义，可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US20080119488A1
公开(公告)日：2008-05-22
申请号：US11572579
申请日：2005-07-24
申请人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
发明人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
IPC分类号： A61K31/497 , C07D211/98 , A61K31/4418 , C07D401/12 , A61K31/513 , C07D401/04 , A61K31/443 , A61P3/00 , A61P25/00 , C12N5/06 , C07K14/00 , A61P9/00 , A61P17/10 , A61K31/4433 , C07D401/14 , A61K31/4439 , A61K31/4545 , C07D409/04 , A61K31/4436
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式（I）化合物，其中n，m，A，R 1，R 2，R 3，R 4和R 5在本文中定义，可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US07998986B2
公开(公告)日：2011-08-16
申请号：US10327813
申请日：2002-12-20
IPC分类号： A61K31/4412 , C07D213/64
CPC分类号： C07D401/04 , C07D213/85 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.
摘要翻译： 提供了调节核受体活性的化合物，组合物和方法。 特别地，提供杂环化合物用于调节核受体的活性，包括肝X受体（LXR）和孤儿核受体。 在某些实施方案中，化合物是N-取代的吡啶酮。
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公开(公告)号：US20080132521A1
公开(公告)日：2008-06-05
申请号：US11829324
申请日：2007-07-27
申请人： Alan T. Johnson , Satoru Kaneko , Raju Mohan , Kozo Oda , Edwin J. Schweiger
发明人： Alan T. Johnson , Satoru Kaneko , Raju Mohan , Kozo Oda , Edwin J. Schweiger
IPC分类号： A61K31/497 , C07D217/24 , A61K31/472 , A61P9/00 , A61P9/10 , C07D401/02
CPC分类号： C07D405/04 , C07D217/24 , C07D409/04
摘要： Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.
摘要翻译： 式（I）化合物：其中n，R 1，R 2，R 3和R 7均为 本文公开的这些文献可用于治疗与核受体活性相关的疾病状态。 包含的药物组合物和使用所述化合物的方法也在本文中公开。
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6.发明授权Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning 失效苯胺的羟肟酸衍生物可用作治疗炭疽中毒的治疗剂公开(公告)号：US08242174B2
公开(公告)日：2012-08-14
申请号：US12011790
申请日：2008-01-30
申请人： Alan T. Johnson , Guan-Sheng Jiao
发明人： Alan T. Johnson , Guan-Sheng Jiao
IPC分类号： A01N37/28 , A61K31/19 , C07C259/04
CPC分类号： C07C259/06 , C07C271/22 , C07C275/30 , C07C311/19 , C07C311/42 , C07C2601/14 , C07D213/61 , C07D241/12 , C07D295/15 , C07D295/155 , C07D307/81 , C07D317/58 , C07D333/28 , C07D333/54
摘要： Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of aniline and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译： 具有下式的化合物其中符号具有本说明书中描述的含义是苯胺的异羟肟酸衍生物，能够抑制炭疽杆菌感染的致死作用，可用于治疗炭疽中毒。
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公开(公告)号：US20120107593A1
公开(公告)日：2012-05-03
申请号：US13141402
申请日：2009-12-04
申请人： Zhengtang Luo , Alan T. Johnson
发明人： Zhengtang Luo , Alan T. Johnson
CPC分类号： C01B31/043 , B01D71/021 , B01D2323/34 , B01D2325/26 , C01B32/23 , G01N27/4145
摘要： Disclosed are graphene oxide membrane materials of high surface area, which membranes suitably have a surface area of above about 200 μm and exhibit electrical conductivity in excess of about 200 S/m. Also provided are methods of synthesizing such membranes, as well as devices and sensors that incorporate these novel grapheme materials.
摘要翻译： 公开了具有高表面积的石墨烯氧化物膜材料，其膜适当地具有高于约200μm的表面积并且具有超过约200S / m的导电性。 还提供了合成这种膜的方法，以及结合这些新颖的图形材料的装置和传感器。
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8.发明申请Hydroxamic acid derivatives of 3-Phenyl propionic acids useful as therapeutic agents for treating anthrax poisoning 失效3-苯基丙酸的羟氨肟酸衍生物可用作治疗炭疽中毒的治疗剂公开(公告)号：US20080188566A1
公开(公告)日：2008-08-07
申请号：US12011888
申请日：2008-01-30
申请人： Alan T. Johnson , Guan-Sheng Jiao
发明人： Alan T. Johnson , Guan-Sheng Jiao
IPC分类号： A61K31/164 , C07C233/00 , A61P31/04
CPC分类号： C07C259/06 , C07B2200/07
摘要： Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译： 具有下式的化合物其中符号具有说明书中描述的含义是3-苯基 - 丙酸的异羟肟酸衍生物，并且能够抑制炭疽杆菌感染的致死作用，并且可用于治疗炭疽中毒。
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9.发明申请Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning 失效苯氧乙酸和类似物的羟肟酸衍生物可用作治疗炭疽中毒的治疗剂公开(公告)号：US20080188565A1
公开(公告)日：2008-08-07
申请号：US12011847
申请日：2008-01-30
申请人： Alan T. Johnson , Guan-Sheng Jiao , Seongjin Kim
发明人： Alan T. Johnson , Guan-Sheng Jiao , Seongjin Kim
IPC分类号： A61K31/164 , C07C233/00 , A61P31/04
CPC分类号： C07C259/06 , C07C317/44 , C07C323/60 , C07D211/26 , C07D307/52 , C07D333/20
摘要： Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译： 具有下式的化合物其中符号具有本说明书中描述的含义是苯氧基乙酸的异羟肟酸衍生物和能够抑制炭疽杆菌感染的致死作用的类似物，可用于治疗炭疽中毒。
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10.发明授权O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性公开(公告)号：US06855832B2
公开(公告)日：2005-02-15
申请号：US10269270
申请日：2002-10-11
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： A01N33/26 , A61K31/655 , C07C61/10 , C07C61/16 , C07C62/00 , C07C69/02 , C07C69/587 , C07C69/76 , C07C69/95 , C07C233/81 , C07C245/10 , C07C251/44 , C07C291/00 , C07C309/65 , C07C317/44 , C07C323/55 , C07D211/70 , C07D211/78 , C07D211/82 , C07D277/30 , C07D309/12 , C07D311/00 , C07D311/04 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D335/04 , C07D339/08 , C07D409/10 , C09B29/033 , C09B29/09 , C09B29/22 , C09B29/36
CPC分类号： C07D339/08 , C07C69/587 , C07C69/734 , C07C69/76 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的化合物具有类视黄醇样或类视黄醇拮抗剂样的生物活性。
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