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1.发明授权Methods and compositions for determining the purity of chemically synthesized nucleic acids 有权用于测定化学合成核酸纯度的方法和组合物公开(公告)号：US08173377B2
公开(公告)日：2012-05-08
申请号：US13016409
申请日：2011-01-28
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , B01J2219/00274 , C07K16/18 , C12Q1/6804 , Y02P20/55
摘要： This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.
摘要翻译： 本申请描述了与有机保护基团共价结合的合成寡聚物（例如寡核苷酸或寡肽）特异性结合的抗体，当有机保护基团不与其共价键合时，该抗体不与该合成低聚物结合。 还公开了制备和使用这些抗体的方法，以及用于制备此类抗体的细胞和携带固定化寡聚物的制品，其可用于具有此类抗体的测定程序。
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2.发明授权Methods and compositions for determining the purity of chemically synthesized nucleic acids 失效用于测定化学合成核酸纯度的方法和组合物公开(公告)号：US08697355B2
公开(公告)日：2014-04-15
申请号：US13670102
申请日：2012-11-06
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , B01J2219/00274 , C07K16/18 , C12Q1/6804 , Y02P20/55
摘要： This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.
摘要翻译： 本申请描述了与有机保护基团共价结合的合成寡聚物（例如寡核苷酸或寡肽）特异性结合的抗体，当有机保护基团不与其共价键合时，该抗体不与该合成低聚物结合。 还公开了制备和使用这些抗体的方法，以及用于制备此类抗体的细胞和携带固定化寡聚物的制品，其可用于具有此类抗体的测定程序。
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3.发明授权公开(公告)号：US08323910B2
公开(公告)日：2012-12-04
申请号：US13440613
申请日：2012-04-05
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , B01J2219/00274 , C07K16/18 , C12Q1/6804 , Y02P20/55
摘要： This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.
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4.发明授权公开(公告)号：US08076461B2
公开(公告)日：2011-12-13
申请号：US10746430
申请日：2003-12-24
CPC分类号： B82Y30/00 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , C07K16/44 , C12P19/34 , C12Q1/6804 , C12Q1/6837 , C40B40/06 , C40B50/14 , G01N33/5308 , G01N33/543 , G01N2500/00 , Y02P20/55 , C12Q2565/531 , C12Q2563/131
摘要： An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are disclosed, along with cells for making such antibodies. Methods of making and using such antibody microarrays are also disclosed.
摘要翻译： 描述了抗体微阵列，其包含固定在底物上的多种抗体，其中每种抗体特异性结合具有与其共价结合的有机保护基的合成低聚物（例如，寡核苷酸或寡肽），该抗体不与该合成寡聚物结合 当有机保护基团不共价结合时。 公开了制备和使用这些抗体的方法以及用于制备此类抗体的细胞。 还公开了制备和使用这种抗体微阵列的方法。
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5.发明授权Methods and compositions for determining the purity of chemically synthesized nucleic acids 有权用于测定化学合成核酸纯度的方法和组合物公开(公告)号：US07901892B2
公开(公告)日：2011-03-08
申请号：US10190795
申请日：2002-07-08
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , B01J2219/00274 , C07K16/18 , C12Q1/6804 , Y02P20/55
摘要： This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.
摘要翻译： 本申请描述了与有机保护基团共价结合的合成寡聚物（例如寡核苷酸或寡肽）特异性结合的抗体，当有机保护基团不与其共价键合时，该抗体不与该合成低聚物结合。 还公开了制备和使用这些抗体的方法，以及用于制备此类抗体的细胞和携带固定化寡聚物的制品，其可用于具有此类抗体的测定程序。
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