公开(公告)号：US20100259832A1

公开(公告)日：2010-10-14

申请号：US12742658

申请日：2008-12-10

申请人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

发明人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

IPC分类号： G02B3/14

CPC分类号： G02B3/14

摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

摘要翻译： 提供了一种可调节流体型透镜系统， 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器，例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用，例如， 在医疗领域内。 用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

公开(公告)号：US08475442B2

公开(公告)日：2013-07-02

申请号：US12663307

申请日：2008-07-07

申请人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

发明人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

IPC分类号： A61B18/04

CPC分类号： A61N7/022 ,  A61B2017/00243 ,  A61N2007/0056 ,  G10K11/30

摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the center of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.

摘要翻译： 适于附接到导管的超声波组件，例如 用于治疗。 超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。 超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。 至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如， 当向电极施加电压时，界面的曲率。 在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。 在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。 这是例如 适用于人体组织的消融或凝血坏死治疗，例如 用于心房颤动治疗。 在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

公开(公告)号：US20100280390A1

公开(公告)日：2010-11-04

申请号：US12522037

申请日：2008-01-10

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Jan Frederik Suijver ,  Ronald Tabaksblat ,  Nijs Cornelis Van Der Vaart ,  Christopher Stephen Hall ,  Anna Teresa Fernandez

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Jan Frederik Suijver ,  Ronald Tabaksblat ,  Nijs Cornelis Van Der Vaart ,  Christopher Stephen Hall ,  Anna Teresa Fernandez

IPC分类号： A61B8/14

CPC分类号： A61B8/12 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/483 ,  G10K11/30

摘要： A catheter apparatus (100, 2000, 3000, 4000, 540) includes an elongated body (110) having proximal (112) and distal (114) ends, an acoustic transducer (130, 2300, 5 3300, 4300, 544), disposed proximate the distal end (114) of the elongated body (110), and a variably-refracting acoustic lens (140, 2200, 3200, 4200, 542) adapted to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.

摘要翻译： 导管装置（100,2000,3000,4000,540）包括具有近端（112）和远端端（114）的细长体（110），设置有声变换器（130,2300,5300,4300,544） 靠近所述细长体（110）的远端（114），以及可变折射声透镜（140,2200,3200,4200,542），其适于动态地调节与耦合到所述声换能器的声波相关联的方向 响应于提供给其的一个或多个控制信号。

公开(公告)号：US08702612B2

公开(公告)日：2014-04-22

申请号：US12522037

申请日：2008-01-10

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Jan Frederik Suijver ,  Ronald Tabaksblat ,  Nijs Cornelis Van Der Vaart ,  Christopher Stephen Hall ,  Anna Teresa Fernandez

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper ,  Jan Frederik Suijver ,  Ronald Tabaksblat ,  Nijs Cornelis Van Der Vaart ,  Christopher Stephen Hall ,  Anna Teresa Fernandez

IPC分类号： A61B8/12 ,  A61B8/14

CPC分类号： A61B8/12 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/483 ,  G10K11/30

摘要： A catheter apparatus includes an elongated body having proximal and distal ends, and an acoustic transducer disposed proximate the distal end of the elongated body. A variably-refracting acoustic lens is provided to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.

摘要翻译： 导管装置包括具有近端和远端的细长主体和靠近细长主体的远端设置的声换能器。 提供可变折射声透镜以响应于提供给其的一个或多个控制信号而动态地调整与耦合到声换能器的声波相关联的方向。

公开(公告)号：US08233221B2

公开(公告)日：2012-07-31

申请号：US12742658

申请日：2008-12-10

申请人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

发明人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

IPC分类号： G02B1/06 ,  G02B3/12

CPC分类号： G02B3/14

摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

摘要翻译： 提供了一种可调节流体型透镜系统， 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器，例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用，例如， 在医疗领域内。 用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

公开(公告)号：US20100185126A1

公开(公告)日：2010-07-22

申请号：US12663307

申请日：2008-07-07

申请人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

发明人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

IPC分类号： A61N7/00

CPC分类号： A61N7/022 ,  A61B2017/00243 ,  A61N2007/0056 ,  G10K11/30

摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the centre of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.

摘要翻译： 适于附接到导管的超声波组件，例如 用于治疗。 超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。 超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。 至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如， 当向电极施加电压时，界面的曲率。 在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。 在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。 这是例如 适用于人体组织的消融或凝血坏死治疗，例如 用于心房颤动治疗。 在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

公开(公告)号：US08764665B2

公开(公告)日：2014-07-01

申请号：US12596841

申请日：2008-04-30

申请人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： A61B8/00

CPC分类号： G10K11/30

摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

摘要翻译： 声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。 每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。 在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

公开(公告)号：US20100087735A1

公开(公告)日：2010-04-08

申请号：US12596841

申请日：2008-04-30

申请人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： A61B8/00 ,  G03B42/06

CPC分类号： G10K11/30

摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

摘要翻译： 声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。 每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。 在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

公开(公告)号：US09901321B2

公开(公告)日：2018-02-27

申请号：US13142299

申请日：2010-01-08

申请人： Erik Harks ,  Szabolcs Deladi ,  Jan Frederik Suijver ,  Ladislav Jankovic ,  Yan Shi ,  Wouter Harry Jacinth Rensen ,  Maya Barley ,  Nijs Cornelis Van Der Vaart

发明人： Erik Harks ,  Szabolcs Deladi ,  Jan Frederik Suijver ,  Ladislav Jankovic ,  Yan Shi ,  Wouter Harry Jacinth Rensen ,  Maya Barley ,  Nijs Cornelis Van Der Vaart

IPC分类号： A61B8/08 ,  A61B8/12 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B17/00 ,  A61B18/00 ,  A61B8/00 ,  A61B90/00

CPC分类号： A61B8/0858 ,  A61B8/12 ,  A61B8/445 ,  A61B8/486 ,  A61B18/02 ,  A61B18/1442 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/20 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2018/00738 ,  A61B2090/376 ,  A61B2090/3784 ,  A61B2218/002

摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

公开(公告)号：US20100229648A1

公开(公告)日：2010-09-16

申请号：US12438170

申请日：2007-04-12

申请人： Jan Frederik Suijver ,  Anna T. Fernandez ,  Christopher S. Hall

发明人： Jan Frederik Suijver ,  Anna T. Fernandez ,  Christopher S. Hall

IPC分类号： G01N29/02

CPC分类号： G10K11/30

摘要： An acoustic device is disclosed having a variably refracting acoustic fluid interface including the boundary between two separate fluid media, means for directing acoustic waves onto the interface, and an acoustic generator or transducer located in one of the fluid media with the acoustic generator having an impedance that is substantially equal to the one said fluid media to minimize signal loss and reflection.

摘要翻译： 公开了一种声学装置，其具有包括两个单独流体介质之间的边界的可变折射声流体界面，用于将声波引导到界面上的装置，以及位于一个流体介质中的声发生器或换能器，声发生器具有阻抗 其基本上等于所述流体介质以最小化信号损失和反射。