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公开(公告)号：US20150150845A1
公开(公告)日：2015-06-04
申请号：US14619242
申请日：2015-02-11
发明人： Kazutomo KINOSHITA , Kohsuke ASOH , Noriyuki FURUICHI , Toshiya ITO , Hatsuo KAWADA , Nobuya ISHII , Hiroshi SAKAMOTO , WooSang HONG , MinJeong PARK , Yoshiyuki ONO , Yasuharu KATO , Kenji MORIKAMI , Takashi EMURA , Nobuhiro OIKAWA
IPC分类号： A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/7056 , A61K31/5377 , A61K31/541 , A61K31/496 , A61K31/454 , A61K31/506
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US20220205009A1
公开(公告)日：2022-06-30
申请号：US17417822
申请日：2019-12-26
发明人： Shojiro SHINOHARA , Takaaki TANIGUCHI , Miki MISAIZU , Kaori NISHIMURA , Mana IWAHASHI , Takashi EMURA , Kazuhiko NAKANO , Masahiko TANAKA , Takamichi OHDAKE , Atsushi OHTA
摘要： In some embodiments, the present disclosure relates to mutated tRNAs in which the first letter of the anticodon has been substituted to lysidine or agmatidine, and translation systems containing the mutated tRNAs. In a specific embodiment, the present disclosure provides mutated tRNAs capable of selectively translating codon NNA. In another embodiment, the present disclosure provides translation systems capable of translating two or three types of amino acids from a single codon box. In still another embodiment, the present disclosure provides novel methods for synthesizing lysidine diphosphate, agmatidine diphosphate, and derivatives thereof.
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公开(公告)号：US20200277327A1
公开(公告)日：2020-09-03
申请号：US16619388
申请日：2018-06-08
摘要： Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.
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公开(公告)号：US20200017442A1
公开(公告)日：2020-01-16
申请号：US16239839
申请日：2019-01-04
发明人： Kazutomo KINOSHITA , Kohsuke ASOH , Noriyuki FURUICHI , Toshiya ITO , Hatsuo KAWADA , Nabuya ISHII , Hiroshi SAKAMOTO , WooSang HONG , MinJeong PARK , Yoshiyuki ONO , Yasuharu KATO , Kenji MORIKAMI , Takashi EMURA , Nobuhiro OIKAWA
IPC分类号： C07D209/58 , C07H15/26 , C07F7/08 , C07D471/10 , C07D413/14 , C07D409/12 , C07D403/12 , C07D401/14 , C07D401/12 , C07D333/52 , C07D307/78 , A61K31/7056 , A61K31/541 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/4178 , A61K31/404 , C07D209/56 , C07D491/107 , C07D471/04 , C07D405/14 , C07D405/12 , C07D403/04 , C07D401/06 , C07D401/04 , C07D333/76 , C07D333/50 , C07D307/92 , C07D307/77 , C07D209/88
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
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公开(公告)号：US20160340308A1
公开(公告)日：2016-11-24
申请号：US15221926
申请日：2016-07-28
发明人： Kazutomo Kinoshita , Kohsuke ASOH , Noriyuki FURUICHI , Toshiya ITO , Hatsuo KAWADA , Nobuya ISHll , Hiroshi SAKAMOTO , WooSang HONG , MinJeong PARK , Yoshiyuki ONO , Yasuharu KATO , Kenji MORIKAMI , Takashi EMURA , Nobuhiro OIKAWA
IPC分类号： C07D209/58 , C07D403/12 , C07D405/12 , C07F7/08 , C07D405/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D401/04 , C07D401/06 , C07D409/12 , C07D471/04 , C07D491/107 , C07H15/26 , C07D471/10 , C07D333/52 , C07D307/78 , C07D401/12
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： （公式中包含的符号的含义如规范中所述）。
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公开(公告)号：US20240166689A1
公开(公告)日：2024-05-23
申请号：US18460300
申请日：2023-09-01
发明人： Shiori KARIYUKI , Takeo IIDA , Miki KOJIMA , Ryuichi TAKEYAMA , Mikimasa TANADA , Tetsuo KOJIMA , Hitoshi IIKURA , Atsushi MATSUO , Takuya SHIRAISHI , Takashi EMURA , Kazuhiko NAKANO , Koji TAKANO , Kousuke ASOU , Takuya TORIZAWA , Ryusuke TAKANO , Nozomi HISADA , Naoaki MURAO , Atsushi OHTA , Kaori KIMURA , Yusuke YAMAGISHI , Tatsuya KATO
IPC分类号： C07K7/64 , C07H21/04 , C07K1/113 , C07K5/087 , C07K5/103 , C07K7/06 , C07K7/08 , C07K11/00 , C07K11/02 , C07K19/00 , C12P21/02
CPC分类号： C07K7/64 , C07H21/04 , C07K1/113 , C07K5/0812 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K11/00 , C07K11/02 , C07K19/00 , C12P21/02 , A61K38/00
摘要： An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
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公开(公告)号：US20230406879A1
公开(公告)日：2023-12-21
申请号：US18459998
申请日：2023-09-01
摘要： Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.
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公开(公告)号：US20230142119A1
公开(公告)日：2023-05-11
申请号：US17860589
申请日：2022-07-08
发明人： Kazutomo KINOSHITA , Kohsuke ASOH , Noriyuki FURUICHI , Toshiya ITO , Hatsuo KAWADA , Nobuya ISHII , Hiroshi SAKAMOTO , WooSang HONG , MinJeong PARK , Yoshiyuki ONO , Yasuharu KATO , Kenji MORIKAMI , Takashi EMURA , Nobuhiro OIKAWA
IPC分类号： C07D209/58 , C07D209/88 , C07D307/77 , C07D307/92 , C07D333/50 , C07D333/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/107 , C07D209/56 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D307/78 , C07D333/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/14 , C07D471/10 , C07F7/08 , C07H15/26
CPC分类号： C07D209/58 , C07D209/88 , C07D307/77 , C07D307/92 , C07D333/50 , C07D333/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/107 , C07D209/56 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D307/78 , C07D333/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/14 , C07D471/10 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder:
(meanings of the symbols that are included in the formula are as given in the specification).-
公开(公告)号：US20190142959A1
公开(公告)日：2019-05-16
申请号：US16099770
申请日：2017-05-11
发明人： Takashi NAKAI , Teruo NAKAMURA , Sayan CHUANOI , Hideyuki TOGAWA , Tsuyoshi SHIMOBOJI , Kazuo HATTORI , Takashi EMURA
IPC分类号： A61K47/61 , A61K47/36 , C08L5/08 , A61K9/00 , A61K31/575
摘要： The present invention provides hyaluronic acid derivatives into which a certain cationic group and a certain hydrophobic group are introduced, the hyaluronic acid derivatives including one or more repeating units represented by the formula (Ia) and one or more repeating units represented by the formula (Ib).
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公开(公告)号：US20240132431A1
公开(公告)日：2024-04-25
申请号：US18270793
申请日：2022-01-06
摘要： The present invention provides a method for producing a compound having an alkylated acidic functional group, the method comprising reacting, in a mixture containing two or more compounds having an acidic functional group as substrates, the compounds with an alkylating agent selected from compounds represented by formula A, formula B, or formula C in the presence of a base to alkylate the acidic functional group.
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