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公开(公告)号：US20140335564A1
公开(公告)日：2014-11-13
申请号：US14258994
申请日：2014-04-22
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US20140343267A1
公开(公告)日：2014-11-20
申请号：US14261257
申请日：2014-04-24
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。
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公开(公告)号：US20140348834A1
公开(公告)日：2014-11-27
申请号：US14260197
申请日：2014-04-23
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： C07K16/24 , C07K16/46 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US20140017246A1
公开(公告)日：2014-01-16
申请号：US13959648
申请日：2013-08-05
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US20140356909A1
公开(公告)日：2014-12-04
申请号：US14263724
申请日：2014-04-28
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US08779101B2
公开(公告)日：2014-07-15
申请号：US13959648
申请日：2013-08-05
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： A61K39/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。
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公开(公告)号：US20140348856A1
公开(公告)日：2014-11-27
申请号：US14262653
申请日：2014-04-25
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。
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公开(公告)号：US08835610B2
公开(公告)日：2014-09-16
申请号：US12718841
申请日：2010-03-05
申请人： Chung-Ming Hsieh , Margaret Hugunin , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers
发明人： Chung-Ming Hsieh , Margaret Hugunin , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。
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公开(公告)号：US20100040537A1
公开(公告)日：2010-02-18
申请号：US12499646
申请日：2009-07-08
申请人： Jjijie Gu , Charles W. Hutchins , Rong-rong Zhu , Jianwei Shen , Maria C. Harris , Eileen Belanger , Anwar Murtaza , Edit Tarcsa , William B. Stine , Chung-ming Hsieh
发明人： Jjijie Gu , Charles W. Hutchins , Rong-rong Zhu , Jianwei Shen , Maria C. Harris , Eileen Belanger , Anwar Murtaza , Edit Tarcsa , William B. Stine , Chung-ming Hsieh
IPC分类号： A61K39/395 , C07K16/00 , C07K19/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/11 , C12N5/10 , C12N1/15 , C12P21/00 , A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00 , A61P19/02 , A61P3/10 , A61P7/00 , A61P3/12 , A61P15/00 , A61P1/00 , A61P27/02 , A61K38/20
CPC分类号： C07K16/18 , A61K31/405 , A61K31/573 , A61K39/39533 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
摘要翻译： 本发明包括前列腺素E2（PGE2）结合蛋白。 本发明涉及野生型，嵌合型，CDR移植和人源化的抗体。 优选的抗体对前列腺素E2具有高亲和力，并在体外和体内中和前列腺素E2活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗原结合部分可用于检测前列腺素E2和用于抑制前列腺素E2活性，例如在患有前列腺素E2活性有害的病症的人类受试者中。
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公开(公告)号：US08624002B2
公开(公告)日：2014-01-07
申请号：US12499646
申请日：2009-07-08
申请人： Jjijie Gu , Charles W. Hutchins , Rong-rong Zhu , Jianwei Shen , Maria C. Harris , Eileen Belanger , Anwar Murtaza , Edit Tarcsa , William B. Stine , Chung-ming Hsieh
发明人： Jjijie Gu , Charles W. Hutchins , Rong-rong Zhu , Jianwei Shen , Maria C. Harris , Eileen Belanger , Anwar Murtaza , Edit Tarcsa , William B. Stine , Chung-ming Hsieh
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K31/405 , A61K31/573 , A61K39/39533 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
摘要翻译： 本发明包括前列腺素E2（PGE2）结合蛋白。 本发明涉及野生型，嵌合型，CDR移植和人源化的抗体。 优选的抗体对前列腺素E2具有高亲和力，并在体外和体内中和前列腺素E2活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗原结合部分可用于检测前列腺素E2和用于抑制前列腺素E2活性，例如在患有前列腺素E2活性有害的病症的人类受试者中。
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