利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.033 秒)

    COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE
    8.
    发明申请
    COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE 有权
    用于抑制HISTONE脱乙酰壳多糖的化合物

    公开(公告)号：US20090076130A1

    公开(公告)日：2009-03-19

    申请号：US11855416

    申请日：2007-09-14

    申请人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

    发明人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

    IPC分类号： A61K31/353 ,  A61P25/28 ,  C07D311/32 ,  A61P35/00

    CPC分类号： C07D311/32

    摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

    摘要翻译： 本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。 该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。 特别地，本发明的化合物可用作抗神经变性疾病和人脊髓性肌萎缩（SMA）的药剂。

    Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly
    9.
    发明授权
    Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly 有权
    使用组蛋白脱乙酰酶抑制剂改变皇家果冻中的MRJP3蛋白

    公开(公告)号：US08784873B2

    公开(公告)日：2014-07-22

    申请号：US12507545

    申请日：2009-07-22

    申请人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jung Chen ,  Wei-Jan Huang ,  Li-Ling Chi

    发明人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jung Chen ,  Wei-Jan Huang ,  Li-Ling Chi

    IPC分类号： A23K1/165 ,  A61K31/352

    CPC分类号： A61K31/353 ,  A01K53/00 ,  A61K31/185 ,  A61K35/644 ,  Y02P20/582

    摘要： The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.

    摘要翻译： 本发明提供了改变皇家果冻中MRJP3的68至64kDa蛋白的比例的方法，包括相对于对照蜂王浆和皇室的具有68至64kDa蛋白质变化比例的MRJP3的蜂王浆的生产方法 果冻生产。 还提供了促进雌蜂的幼虫生长的方法，包括将本发明的蜂王浆的雌蜂喂给蜂王浆。 还提供了一种生产尺寸大于正常的蜜蜂幼虫，蛹和雌蜂的方法。

    Compounds for the inhibition of histone deacetylase
    10.
    发明授权
    Compounds for the inhibition of histone deacetylase 有权
    用于抑制组蛋白脱乙酰酶的化合物

    公开(公告)号：US08008344B2

    公开(公告)日：2011-08-30

    申请号：US11855416

    申请日：2007-09-14

    申请人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

    发明人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

    IPC分类号： A61K31/352 ,  C07D311/32

    CPC分类号： C07D311/32

    摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

    摘要翻译： 本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。 该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。 特别地，本发明的化合物可用作抗神经变性疾病和人脊髓性肌萎缩（SMA）的药剂。