-
公开(公告)号：US20070224118A1
公开(公告)日：2007-09-27
申请号：US11538350
申请日：2006-10-03
申请人： Cindy Sprecher , Julia Novak , James West , Scott Presnell , Richard Holly , Andrew Nelson
发明人： Cindy Sprecher , Julia Novak , James West , Scott Presnell , Richard Holly , Andrew Nelson
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。
-
公开(公告)号：US20070099269A1
公开(公告)日：2007-05-03
申请号：US11549772
申请日：2006-10-16
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20070098683A1
公开(公告)日：2007-05-03
申请号：US11551139
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K38/19 , A61K38/20 , A61K39/395
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20070066808A1
公开(公告)日：2007-03-22
申请号：US11551820
申请日：2006-10-23
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C07K14/52
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20070048845A1
公开(公告)日：2007-03-01
申请号：US11551344
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20070014800A1
公开(公告)日：2007-01-18
申请号：US11532776
申请日：2006-09-18
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K39/395 , C12P21/04 , C07K16/24
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
-
公开(公告)号：US20070048259A1
公开(公告)日：2007-03-01
申请号：US11551356
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
-
公开(公告)号：US20070166794A1
公开(公告)日：2007-07-19
申请号：US11551811
申请日：2006-10-23
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
-
公开(公告)号：US20070098682A1
公开(公告)日：2007-05-03
申请号：US11551136
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20070092485A1
公开(公告)日：2007-04-26
申请号：US11551807
申请日：2006-10-23
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： A61K38/17
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
-
-
-
-
-
-
-
-
搜索结果
84 条记录 (耗时 0.049 秒)
