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公开(公告)号:US20070048303A1
公开(公告)日:2007-03-01
申请号:US11552243
申请日:2006-10-24
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US20070141051A1
公开(公告)日:2007-06-21
申请号:US11552238
申请日:2006-10-24
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US20050214801A1
公开(公告)日:2005-09-29
申请号:US10982555
申请日:2004-11-05
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: C07K14/715 , C12Q1/68 , C07H21/04 , C12N15/09
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20070049528A1
公开(公告)日:2007-03-01
申请号:US11551337
申请日:2006-10-20
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K38/17 , C07K14/715
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US20070049527A1
公开(公告)日:2007-03-01
申请号:US11551328
申请日:2006-10-20
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20070105777A1
公开(公告)日:2007-05-10
申请号:US11620994
申请日:2007-01-08
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytorl7, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20070048309A1
公开(公告)日:2007-03-01
申请号:US11551347
申请日:2006-10-20
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US20070048308A1
公开(公告)日:2007-03-01
申请号:US11551334
申请日:2006-10-20
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US20070048307A1
公开(公告)日:2007-03-01
申请号:US11551322
申请日:2006-10-20
申请人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人: Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 新的多肽,编码多肽的多核苷酸以及相关组合物和方法公开于zyctor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zyctor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20070048835A1
公开(公告)日:2007-03-01
申请号:US11552721
申请日:2006-10-25
申请人: Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人: Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号: C12P21/06 , C07H21/04 , C07K14/715
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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