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公开(公告)号：US20130236395A1
公开(公告)日：2013-09-12
申请号：US13885466
申请日：2011-11-07
申请人： Clare Jones , Amanda Ewan , Duncan Wynn , Alessandra Gaeta , James Nairne
发明人： Clare Jones , Amanda Ewan , Duncan Wynn , Alessandra Gaeta , James Nairne
IPC分类号： A61K51/04
CPC分类号： A61K51/0455 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D295/067 , C07D401/04 , C07D401/12
摘要： Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
摘要翻译： 描述了用作阿尔茨海默氏病Tau病理学成像探针的式（I）的杂环化合物。 还描述了制备这种化合物的组合物和方法。
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公开(公告)号：US09040021B2
公开(公告)日：2015-05-26
申请号：US13885466
申请日：2011-11-07
申请人： Clare Jones , Amanda Ewan , Duncan Wynn , Alessandra Gaeta , James Nairne
发明人： Clare Jones , Amanda Ewan , Duncan Wynn , Alessandra Gaeta , James Nairne
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D295/067 , C07D401/04 , C07D401/12
CPC分类号： A61K51/0455 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D295/067 , C07D401/04 , C07D401/12
摘要： Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
摘要翻译： 描述了用作阿尔茨海默氏病Tau病理学成像探针的式（I）的杂环化合物。 还描述了制备这种化合物的组合物和方法。
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公开(公告)号：US08158804B2
公开(公告)日：2012-04-17
申请号：US12521195
申请日：2008-01-11
IPC分类号： C07D213/89 , C07D213/69
CPC分类号： C07D213/81 , A61K49/103
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子如铁（III）和钆（III）形成络合物的螯合剂。 本发明还涉及形成的复合物及其作为MRI造影剂的用途。
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公开(公告)号：US20100056787A1
公开(公告)日：2010-03-04
申请号：US12521195
申请日：2008-01-11
IPC分类号： C07D213/89 , C07D213/69
CPC分类号： C07D213/81 , A61K49/103
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子如铁（III）和钆（III）形成络合物的螯合剂。 本发明还涉及形成的复合物及其作为MRI造影剂的用途。
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公开(公告)号：US08790619B2
公开(公告)日：2014-07-29
申请号：US13258465
申请日：2010-03-26
申请人： Harry John Wadsworth , Bo Shan , Dennis O'Shea , Joanna Marie Passmore , William John Trigg , Amanda Ewan
发明人： Harry John Wadsworth , Bo Shan , Dennis O'Shea , Joanna Marie Passmore , William John Trigg , Amanda Ewan
CPC分类号： C07D209/94 , A61K51/0446 , A61K51/0455 , A61K51/0468 , C07B59/002 , C07B2200/05 , C07D209/88 , C07D295/192 , C07D401/06 , C07D495/04
摘要： An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
摘要翻译： 通过本发明提供的以吲哚为基础的体内显像剂以高亲和力结合PBR，在给药后具有良好的摄入脑中，并具有良好的选择性结合PBR。 本发明还包括可用于合成本发明的体内显像剂的前体化合物，以及包含使用所述前体化合物的所述体内显像剂的合成方法和用于实施所述方法的试剂盒。 还提供了用于体内成像剂的自动合成的盒。 本发明的其它方面包括包含本发明的体内显像剂的放射性药物组合物和使用所述体内显像剂的方法。
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公开(公告)号：US20120020884A1
公开(公告)日：2012-01-26
申请号：US13258465
申请日：2010-03-26
申请人： Harry John Wadsworth , Bo Shan , Dennis O'shea , Joanna Marie Passmore , William John Trigg , Amanda Ewan
发明人： Harry John Wadsworth , Bo Shan , Dennis O'shea , Joanna Marie Passmore , William John Trigg , Amanda Ewan
IPC分类号： A61K51/04 , B01J19/00 , C07D401/08 , C07D495/04 , C07D209/94 , C07D209/80
CPC分类号： C07D209/94 , A61K51/0446 , A61K51/0455 , A61K51/0468 , C07B59/002 , C07B2200/05 , C07D209/88 , C07D295/192 , C07D401/06 , C07D495/04
摘要： An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
摘要翻译： 通过本发明提供的以吲哚为基础的体内显像剂以高亲和力结合PBR，在给药后具有良好的摄入脑中，并具有良好的选择性结合PBR。 本发明还包括可用于合成本发明的体内显像剂的前体化合物，以及包含使用所述前体化合物的所述体内显像剂的合成方法和用于实施所述方法的试剂盒。 还提供了用于体内成像剂的自动合成的盒。 本发明的其它方面包括包含本发明的体内显像剂的放射性药物组合物和使用所述体内显像剂的方法。
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公开(公告)号：US20100008864A1
公开(公告)日：2010-01-14
申请号：US12499281
申请日：2009-07-08
申请人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
发明人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
CPC分类号： A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译： 本发明涉及式（I）和（II）的新化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。
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