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39 条记录 (耗时 0.028 秒)

    Indole derivatives
    6.
    发明授权
    Indole derivatives 有权
    吲哚衍生物

    公开(公告)号：US08790619B2

    公开(公告)日：2014-07-29

    申请号：US13258465

    申请日：2010-03-26

    申请人： Harry John Wadsworth ,  Bo Shan ,  Dennis O'Shea ,  Joanna Marie Passmore ,  William John Trigg ,  Amanda Ewan

    发明人： Harry John Wadsworth ,  Bo Shan ,  Dennis O'Shea ,  Joanna Marie Passmore ,  William John Trigg ,  Amanda Ewan

    IPC分类号： A61K51/00 ,  A61K36/14

    CPC分类号： C07D209/94 ,  A61K51/0446 ,  A61K51/0455 ,  A61K51/0468 ,  C07B59/002 ,  C07B2200/05 ,  C07D209/88 ,  C07D295/192 ,  C07D401/06 ,  C07D495/04

    摘要： An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.

    摘要翻译： 通过本发明提供的以吲哚为基础的体内显像剂以高亲和力结合PBR，在给药后具有良好的摄入脑中，并具有良好的选择性结合PBR。 本发明还包括可用于合成本发明的体内显像剂的前体化合物，以及包含使用所述前体化合物的所述体内显像剂的合成方法和用于实施所述方法的试剂盒。 还提供了用于体内成像剂的自动合成的盒。 本发明的其它方面包括包含本发明的体内显像剂的放射性药物组合物和使用所述体内显像剂的方法。

    CONTRAST AGENTS
    8.
    发明申请
    CONTRAST AGENTS 失效
    对比剂

    公开(公告)号：US20100260685A1

    公开(公告)日：2010-10-14

    申请号：US12739977

    申请日：2008-10-29

    申请人： Duncan George Wynn ,  Ian Martin Newington ,  Harry John Wadsworth

    发明人： Duncan George Wynn ,  Ian Martin Newington ,  Harry John Wadsworth

    IPC分类号： A61K49/04 ,  C07C275/40 ,  C07D413/14

    CPC分类号： A61K49/04 ,  A61K49/0438 ,  C07C237/46

    摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

    摘要翻译： 本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式R-Y-X-Z-R化合物，其中每个R表示进一步被亲水部分取代的三碘化苯基残基，Y Z为脲和氨基甲酸酯基，X为可进一步取代的亚烷基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

    Contrast agents
    9.
    发明授权
    Contrast agents 失效
    对比剂

    公开(公告)号：US08551449B2

    公开(公告)日：2013-10-08

    申请号：US12739977

    申请日：2008-10-29

    申请人： Duncan George Wynn ,  Ian Martin Newington ,  Harry John Wadsworth

    发明人： Duncan George Wynn ,  Ian Martin Newington ,  Harry John Wadsworth

    IPC分类号： A61K49/04 ,  A61K49/00

    CPC分类号： A61K49/04 ,  A61K49/0438 ,  C07C237/46

    摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

    摘要翻译： 本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式RYXZR化合物，其中每个R表示进一步被亲水部分取代的三碘代苯基，Y和Z是脲和氨基甲酸酯基团， X是可以被进一步取代的亚烷基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

    Contrast agents
    10.
    发明授权
    Contrast agents 失效
    对比剂

    公开(公告)号：US08066974B2

    公开(公告)日：2011-11-29

    申请号：US12299794

    申请日：2007-05-10

    申请人： Duncan Wynn ,  Harry John Wadsworth ,  Ian Martin Newington

    发明人： Duncan Wynn ,  Harry John Wadsworth ,  Ian Martin Newington

    IPC分类号： A61K49/04

    CPC分类号： C07C275/42 ,  A61K49/0433 ,  C07C271/28

    摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

    摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有脲或氨基甲酸酯官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。