公开(公告)号：US20070123586A1

公开(公告)日：2007-05-31

申请号：US10580413

申请日：2004-11-17

申请人： Claude Lardy ,  Phillippe Guedat ,  Lidia Caputo

发明人： Claude Lardy ,  Phillippe Guedat ,  Lidia Caputo

IPC分类号： A61K31/277 ,  A61K31/195 ,  A61K31/13

CPC分类号： A61K31/165 ,  A61K31/135 ,  A61K31/275 ,  A61K31/655 ,  C07C243/06 ,  C07C255/63 ,  C07C317/34 ,  C07C317/36 ,  C07C323/48

摘要： The invention relates to a compound of the formula I in which: R1 represents, independently of each other, a halogen atom; an aliphatic hydrocarbon-based group optionally substituted and/or optionally interrupted by one or more oxygen or sulfur atoms; a nitro group; a cyano group; an amino group; a mono- or dialkylamino group; an alkylcarbonyl group; a carboxyl group; an alkylcarbonylamino group; an alkylsulfonyl group; R2 represents, independently of each other, a cyano group; a hydroxyl group, an alkylcarbonyl group; a carboxyl group; an alkoxycarbonyl group; an unsubstituted amide group; or a linear or branched alkyl group substituted by a cyano, hydroxyl, carboxyl, alkoxycarbonyl or unsubstituted amide group; i and j independently being 1 to 5, with the exclusion of the compound for which i and j=1 and R1=carboxyl and R2=alkoxycarbonyl or R1=CF3 and R2=carboxyl, and also the pharmaceutically acceptable derivatives, salts, solvates and stereoisomers thereof, including mixtures thereof in all proportions.

摘要翻译： 本发明涉及式I化合物，其中：R 1表示彼此独立的卤素原子; 任选被一个或多个氧或硫原子取代和/或任选地中断的脂族烃基; 硝基; 氰基; 氨基; 单或二烷基氨基; 烷基羰基; 羧基; 烷基羰基氨基; 烷基磺酰基; R 2 2彼此独立地表示氰基; 羟基，烷基羰基; 羧基; 烷氧基羰基; 未取代的酰胺基; 或被氰基，羟基，羧基，烷氧基羰基或未取代的酰胺基取代的直链或支链烷基; i和j独立地为1至5，排除i和j = 1且R 1 =羧基和R 2 =烷氧基羰基或R SUB的化合物 还有其药学上可接受的衍生物，盐，溶剂化物和立体异构体，包括其各种比例的混合物。