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公开(公告)号：US20240253023A1
公开(公告)日：2024-08-01
申请号：US11867898
申请日：2007-10-05
IPC分类号： B01J31/02 , B01J31/04 , B01J31/06 , B01J31/12 , B01J31/18 , B01J31/22 , C07B37/02 , C07B37/12 , C07C45/46 , C07C45/69 , C07C67/00 , C07C255/10 , C07C255/17 , C07C255/27 , C07C255/46 , C07C255/65 , C07C257/14 , C07C311/03 , C07C311/04 , C07C311/09 , C07C311/48 , C07C317/04 , C07C317/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/44 , C07D207/452 , C07D213/76 , C07D219/10 , C07D231/18 , C07D233/90 , C07D239/60 , C07D241/42 , C07D249/04 , C07D249/10 , C07D249/12 , C07D251/70 , C07D277/64 , C07D277/82 , C07D285/125 , C07D285/135 , C07D285/15 , C07D285/16 , C07D303/34 , C07D307/54 , C07D307/64 , C07D311/52 , C07D311/58 , C07D311/82 , C07D319/06 , C07D333/16 , C07D333/24 , C07D405/06 , C07D409/12 , C07D417/10 , C07D417/14 , C07F17/02 , C08F4/04 , C08G65/334 , C09B69/00 , C09B69/02 , C09B69/10 , H01B1/12 , H01G9/022 , H01G11/02 , H01G11/62 , H01M4/00 , H01M4/38 , H01M4/58 , H01M4/62 , H01M6/00 , H01M6/16 , H01M6/18 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0567 , H01M10/0568 , G02F1/1516 , G02F1/1523 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/134 , H01M4/40 , H01M4/48 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/60 , H01M4/66 , H01M6/04
CPC分类号： B01J31/0224 , B01J31/0215 , B01J31/0222 , B01J31/0225 , B01J31/0227 , B01J31/0235 , B01J31/0239 , B01J31/0247 , B01J31/0251 , B01J31/0252 , B01J31/0267 , B01J31/0271 , B01J31/0281 , B01J31/0288 , B01J31/0289 , B01J31/04 , B01J31/06 , B01J31/068 , B01J31/124 , B01J31/1815 , B01J31/2208 , C07B37/02 , C07B37/12 , C07C45/46 , C07C45/69 , C07C67/00 , C07C255/10 , C07C255/17 , C07C255/27 , C07C255/46 , C07C255/65 , C07C257/14 , C07C311/03 , C07C311/04 , C07C311/09 , C07C311/48 , C07C317/04 , C07C317/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/44 , C07D207/452 , C07D213/76 , C07D219/10 , C07D231/18 , C07D233/90 , C07D239/60 , C07D241/42 , C07D249/04 , C07D249/10 , C07D249/12 , C07D251/70 , C07D277/64 , C07D277/82 , C07D285/125 , C07D285/135 , C07D285/15 , C07D285/16 , C07D303/34 , C07D307/54 , C07D307/64 , C07D311/52 , C07D311/58 , C07D311/82 , C07D319/06 , C07D333/16 , C07D333/24 , C07D405/06 , C07D409/12 , C07D417/10 , C07D417/14 , C07F17/02 , C08F4/04 , C08G65/3344 , C09B69/00 , C09B69/02 , C09B69/10 , H01B1/122 , H01B1/128 , H01G9/022 , H01G11/02 , H01G11/62 , H01M4/00 , H01M4/382 , H01M4/5815 , H01M4/625 , H01M6/00 , H01M6/166 , H01M6/181 , H01M6/183 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0567 , H01M10/0568 , B01J2231/122 , B01J2231/14 , B01J2231/326 , B01J2231/341 , B01J2231/348 , B01J2231/4205 , B01J2231/543 , B01J2531/35 , B01J2531/824 , C07C2601/10 , C07C2602/42 , G02F2001/1518 , G02F1/1525 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/134 , H01M4/405 , H01M4/48 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/5825 , H01M4/60 , H01M4/661 , H01M6/04 , H01M6/164 , H01M6/168 , Y02E60/13 , Y10S430/127 , Y10T29/49108 , Y10T428/2918
摘要： The invention concerns ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic portion M+m in sufficient numbers to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NO+, an ammonium —NH4+, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic portion matches the formula RF—SOx—N−Z, where RF is a perflourinated group, x is 1 or 3, and Z is an electroattractive substituent. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorants and the catalysis of various chemical reactions.
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公开(公告)号：US09969689B2
公开(公告)日：2018-05-15
申请号：US15439308
申请日：2017-02-22
发明人： Darryl David Dixon , Jonas Grina , John A. Josey , James P. Rizzi , Stephen T. Schlachter , Eli M. Wallace , Bin Wang , Paul Wehn , Rui Xu , Hanbiao Yang
IPC分类号： C07C43/29 , C07C43/275 , A61K31/09 , C07D213/85 , C07C317/22 , C07D213/65
CPC分类号： C07D213/85 , A61K31/09 , A61K31/10 , A61K41/0038 , A61P35/00 , C07C43/205 , C07C43/225 , C07C43/23 , C07C43/263 , C07C43/275 , C07C43/285 , C07C43/29 , C07C205/22 , C07C255/54 , C07C255/56 , C07C311/29 , C07C313/06 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/34 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/22 , C07C381/10 , C07C2602/04 , C07C2602/08 , C07C2602/10 , C07C2603/94 , C07D213/65 , C07D213/89 , C07D231/56
摘要： The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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公开(公告)号：US20170217892A1
公开(公告)日：2017-08-03
申请号：US15439494
申请日：2017-02-22
发明人： Darryl David Dixon , Jonas Grina , John A. Josey , James P. Rizzi , Stephen T. Schlachter , Eli M. Wallace , Bin Wang , Paul Wehn , Rui Xu , Hanbiao Yang
IPC分类号： C07D213/85 , C07C317/22 , C07C317/36 , C07C381/10
CPC分类号： C07D213/85 , A61K31/09 , A61K31/10 , A61K41/0038 , A61P35/00 , C07C43/205 , C07C43/225 , C07C43/23 , C07C43/263 , C07C43/275 , C07C43/285 , C07C43/29 , C07C205/22 , C07C255/54 , C07C255/56 , C07C311/29 , C07C313/06 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/34 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/22 , C07C381/10 , C07C2602/04 , C07C2602/08 , C07C2602/10 , C07C2603/94 , C07D213/65 , C07D213/89 , C07D231/56
摘要： The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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公开(公告)号：US20170050925A9
公开(公告)日：2017-02-23
申请号：US14482718
申请日：2014-09-10
申请人： ALLERGAN, INC.
发明人： HAIQING YUAN , RICHARD L. BEARD , MICHAEL E. GARST , JOHN E. DONELLO , XIAOXIA LIU , VEENA VISWANATH
IPC分类号： C07C311/21 , C07D277/40 , C07D233/64 , C07D405/12 , C07D307/82
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新的硫衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
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公开(公告)号：US09533947B2
公开(公告)日：2017-01-03
申请号：US14292087
申请日：2014-05-30
IPC分类号： C07C311/16 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/85 , C07D207/04 , C07D317/48 , C07D237/20 , C07D271/113 , C07C255/60 , C07C257/18 , C07C323/49 , C07D217/04 , C07D207/16 , C07D295/26 , C07D305/06 , C07C311/21 , C07C311/29 , C07C317/44 , C07C317/48 , C07D213/76 , C07D213/80 , C07D223/04 , C07D239/42 , C07D261/14 , C07D277/46 , C07D403/12 , C07D413/12 , C07D417/12 , C07D311/16 , C07C311/46 , C07C317/40 , C07C323/62 , C07C311/47 , C07C317/22 , C07C317/34 , C07C323/20 , C07C323/42 , C07C235/60
CPC分类号： C07C311/21 , C07B2200/07 , C07C235/60 , C07C255/60 , C07C257/18 , C07C311/16 , C07C311/29 , C07C311/46 , C07C311/47 , C07C317/22 , C07C317/34 , C07C317/40 , C07C317/44 , C07C317/48 , C07C323/20 , C07C323/42 , C07C323/49 , C07C323/62 , C07C2601/02 , C07D207/16 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D217/04 , C07D223/04 , C07D237/20 , C07D239/42 , C07D261/14 , C07D271/113 , C07D277/46 , C07D295/26 , C07D305/06 , C07D311/16 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
摘要翻译： 苯甲酰胺化合物及其衍生物，可用于选择性抑制SIRT2酶和/或用于治疗亨廷顿病的治疗用途。
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公开(公告)号：US09328067B2
公开(公告)日：2016-05-03
申请号：US13795850
申请日：2013-03-12
申请人： ALLERGAN, INC.
发明人： Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： C07C311/21 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C317/34 , C07C317/44 , A61P29/00 , C07D405/12 , C07D307/82 , C07D233/64 , C07D417/12 , C07D213/32 , C07D413/12 , C07D307/64
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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公开(公告)号：US20160083342A1
公开(公告)日：2016-03-24
申请号：US14754493
申请日：2015-06-29
申请人： ALLERGAN, INC.
发明人： HAIQING YUAN , RICHARD L. BEARD , XIAOXIA LIU , JOHN E. DONELLO , VEENA VISWANATH , MICHAEL E. GARST
IPC分类号： C07C323/67 , C07D307/82 , C07C317/42 , C07D307/64 , C07C317/50 , C07D213/32 , C07D333/34 , C07D405/12 , C07D233/64
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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公开(公告)号：US09035096B2
公开(公告)日：2015-05-19
申请号：US14049452
申请日：2013-10-09
IPC分类号： C07C213/02 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4965 , A61K31/497 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/34 , C07C323/49 , C07D213/46 , C07D213/50 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/89 , C07D237/08 , C07D239/26 , C07D239/42 , C07D333/34 , C07D333/62 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/14 , C07D513/04 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61P1/00 , A61P29/00
CPC分类号： C07C311/29 , C07C311/21 , C07C311/44 , C07C311/46 , C07C317/34 , C07C323/49 , C07D213/46 , C07D213/50 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/89 , C07D237/08 , C07D239/26 , C07D239/42 , C07D333/34 , C07D333/62 , C07D401/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/14 , C07D513/04
摘要： The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.
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公开(公告)号：US08791161B2
公开(公告)日：2014-07-29
申请号：US13772188
申请日：2013-02-20
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , John E. Donello , Xiaoxia Liu , Veena Viswanath
IPC分类号： C07C311/44 , C07C323/09 , C07C317/22 , A61K31/18 , A61K31/4402 , A61K31/4406 , A61K31/4164 , A61P31/00 , C07F9/32 , C07D405/12 , C07C317/36 , C07D307/82 , C07F9/53 , C07D233/64 , C07D417/12 , C07D333/34 , C07F9/30 , C07F9/6533 , C07F9/40 , C07D213/52 , C07F9/59 , C07C323/49
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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公开(公告)号：US08546452B2
公开(公告)日：2013-10-01
申请号：US12088861
申请日：2006-10-11
申请人： Shin-ya Ohnuma , Takeshi Hasegawa , Tomoyuki Sada
发明人： Shin-ya Ohnuma , Takeshi Hasegawa , Tomoyuki Sada
IPC分类号： A01N37/52 , A61K31/155 , C07C257/00
CPC分类号： C07C317/34 , C07C257/22 , C07D213/74 , C07D215/04 , C07D217/02 , C07D295/185 , C07D307/46 , C07D333/22
摘要： The present invention relates to arylamidrazone derivatives having an antagonistic action against S1P3 receptors represented by the following formula (1) or a pharmaceutically acceptable salt thereof:
摘要翻译： 本发明涉及对由下式（1）表示的S1P3受体或其药学上可接受的盐具有拮抗作用的芳基氨基腙衍生物：
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