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公开(公告)号：US20140155334A1
公开(公告)日：2014-06-05
申请号：US14089380
申请日：2013-11-25
申请人： Jean-Marie Lehn , Yves Claude Nicolau , Rajamalleswaramma Jogireddy , Adam H. Brockman , John Hey , Yongxin Yu
发明人： Jean-Marie Lehn , Yves Claude Nicolau , Rajamalleswaramma Jogireddy , Adam H. Brockman , John Hey , Yongxin Yu
IPC分类号： A61K31/7028 , C07H11/04
CPC分类号： A61K31/7028 , A61K31/7024 , C07H11/04 , C07H13/00 , C07H13/12 , C07H15/04
摘要： The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
摘要翻译： 本发明尤其提供单糖，二糖和寡糖的磷酸化和焦磷酸衍生物以及这些化合物的结构衍生物。 这些化合物具有多种用途，包括用于药物应用。 还提供了用于治疗疾病的方法，包括与氧气递送相关的疾病。
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公开(公告)号：US20130059820A1
公开(公告)日：2013-03-07
申请号：US13426148
申请日：2012-03-21
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的修饰的肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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公开(公告)号：US08178514B2
公开(公告)日：2012-05-15
申请号：US13024922
申请日：2011-02-10
IPC分类号： A61K31/683 , A61P7/00 , A61P9/10
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的修饰的肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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公开(公告)号：US5236835A
公开(公告)日：1993-08-17
申请号：US809049
申请日：1991-12-17
CPC分类号： C12N13/00 , A61K9/5068 , C12N5/0006
摘要： A method of incorporating human CD4 or glycophorin into a red blood cell membrane is provided comprising exposing the red blood cell to an electric field while the cell is suspended in an electro-insertion medium in the presence of a buffered solution (suspension) of the proteins. These proteins bear a hydrophobic membrane spanning sequence. The resultant cell of the electro-insertion is then contacted with a resealing medium.
摘要翻译： 提供将人CD4或血型糖蛋白掺入红细胞膜的方法，包括将红细胞暴露于电场，同时在蛋白质的缓冲溶液（悬浮液）存在的情况下将细胞悬浮于电插入介质中 。 这些蛋白质具有疏水膜跨越序列。 然后将所得的电插入细胞与再密封介质接触。
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公开(公告)号：US4321259A
公开(公告)日：1982-03-23
申请号：US23044
申请日：1979-03-22
IPC分类号： A61K31/56 , A61K9/00 , A61K9/107 , A61K9/127 , A61K9/50 , A61K31/685 , A61K35/14 , A61K35/18 , A61K38/00 , A61K38/16 , A61P7/08
CPC分类号： A61K9/5068 , A61K35/18 , A61K9/127
摘要： The invention provides erythrocytes of improved O.sub.2 -release properties having fused thereto small allosteric effectors, f.i. inositol hexaphosphate-containing lipid vesicles. Also included in the invention is a method for making said erythrocytes and plasma containing said erythrocytes.
摘要翻译： 本发明提供具有与其变小的变构效应子融合的改善的O 2释放性质的红细胞，f.i。 含有肌醇六磷酸的脂质囊泡。 本发明还包括制备含有红细胞的红细胞和血浆的方法。
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公开(公告)号：US08926983B2
公开(公告)日：2015-01-06
申请号：US10590073
申请日：2005-02-22
IPC分类号： A61K39/00 , C07K14/47 , C07K16/18 , A61K39/385 , A61K9/127
CPC分类号： C07K16/18 , A61K9/127 , A61K39/0007 , A61K39/385 , A61K2039/505 , A61K2039/55555 , A61K2039/6093 , C07K14/4711 , C07K2317/10 , C07K2317/34 , C07K2317/70
摘要： The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.
摘要翻译： 本发明包括引发高免疫应答的新型组合物和方法，具有产生构象敏感性抗体的极大特异性。 这些抗体识别多种抗原上的特异性表位，包括但不限于淀粉样蛋白，朊病毒蛋白，P170糖蛋白。 本发明的新型组合物包含通常包含肽序列的超分子抗原构建体，其共价连接于聚乙二醇化赖氨酸，导致修饰和增强的肽呈递。 本发明的独特的修饰方法适用于各种肽，并且最终可用于治疗剂型和疾病和病症如阿尔茨海默病的疫苗。
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7.发明申请CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN 审中-公开硝基磷酸三钙磷酸钙/钠盐作为HEMOGLOBIN的独立效应公开(公告)号：US20100029593A1
公开(公告)日：2010-02-04
申请号：US12554734
申请日：2009-09-04
CPC分类号： A61K31/6615 , A61K31/66 , C07F9/093
摘要： The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
摘要翻译： 本发明涉及三水磷酸肌醇的混合钙/钠盐，其制备方法和使用方法。 混合的钙/钠盐可以是三磷酸肌醇的单钙四钠盐。 使用方法包括以有效量施用上述盐，以治疗由与肺或循环系统功能不足相关的缺氧或其它病症所引起的疾病，例如各种类型的癌症和阿尔茨海默氏病。
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公开(公告)号：US07618954B2
公开(公告)日：2009-11-17
申请号：US11328313
申请日：2006-01-09
IPC分类号： A61K31/663 , C07F9/02
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的改性肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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9.发明申请公开(公告)号：US20090202627A1
公开(公告)日：2009-08-13
申请号：US12424034
申请日：2009-04-15
申请人： Yves Claude NICOLAU
发明人： Yves Claude NICOLAU
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/55555 , C07K14/4711 , C07K14/4713 , C07K14/79 , C07K2319/00 , C12N2799/026
摘要： The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
摘要翻译： 本发明一般涉及疾病状态的检测，治疗或预防。 具体地，本发明涉及淀粉样变性或淀粉样蛋白相关疾病的检测，治疗或预防。 本发明还包括包含治疗性疫苗，抗血清和分子构建体的方法和组合物，其包含其中编码的表达载体和融合蛋白。
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10.发明申请THERAPEUTIC VACCINE TARGETED AGAINST P-GLYCOPROTEIN 170 FOR INHIBITING MULTIDRUG RESISTANCE IN THE TREATMENT OF CANCERS 审中-公开针对P-GLYCOPROTEIN 170针对抑制癌症治疗耐多药耐药性的治疗性酒精公开(公告)号：US20080026995A1
公开(公告)日：2008-01-31
申请号：US11550788
申请日：2006-10-18
CPC分类号： G01N33/57484 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K47/64 , A61K47/645 , A61K47/65 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , C07K14/705 , G01N2400/00
摘要： The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
摘要翻译： 本发明涉及包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物。 肽可以共价连接到可以是聚乙二醇（PEG），聚甘氨酸，聚赖氨酸或适于人类使用的任何聚合物链的间隔物上，并且其自由端与磷脂例如磷脂酰乙醇胺或任何其它化学上合适的磷脂偶联。
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