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1.发明授权Pyrimidin-6-yl acethydroxamic acids, their therapeutic application and their process of preparation 失效吡咯烷-6-YL乙酰氧基酸，其治疗应用及其制备方法
公开(公告)号：US4013768A
公开(公告)日：1977-03-22
申请号：US554532
申请日：1975-03-03
IPC分类号： C07D239/28 , A61K31/505 , C07D239/42 , C07D413/12 , C07D239/26
CPC分类号： C07D239/42 , C07D413/12
摘要： Compounds of the formula ##STR1## in which R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy.The compounds are prepared by 2-Ar-4-chloro-pyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.
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公开(公告)号：US4061855A
公开(公告)日：1977-12-06
申请号：US749221
申请日：1976-12-10
IPC分类号： C07D413/12 , A61K31/535
CPC分类号： C07D413/12 , Y10S514/869 , Y10S514/925 , Y10S514/929
摘要： Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by reacting 2-Ar-4-chloropyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.
摘要翻译： 其中R为氨基羰基苯基的化合物，其中氨基为-NH 2，吡咯烷子基，哌啶子基或吗啉代，Ar为被氯，氟，三氟甲基，亚甲二氧基或一个或多个甲氧基取代的苯基。 该化合物通过使2-氨基-4-氯嘧啶-6-基乙酸乙酯与“IMAGE”反应，然后使该反应产物与盐酸羟胺反应制备。 该化合物具有血管舒张，抗溃疡，呼吸消炎，降血压，利尿，抗抑郁，镇痛，抗炎和神经营养特性。
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3.发明授权Certain 6-(dialkylamino, pyrrolidino and piperidino)ethoxy-4,7-dimethoxy-5-(3-phenyl-1-hydroxypropyl)2,3-dihydrob enzofurans 失效某些6-（二烷基氨基，吡咯烷子基和哌啶子基）乙氧基-4,7-二甲氧基-5-（3-苯基-1-羟丙基）2,3-二氢苯并呋喃
公开(公告)号：US3971793A
公开(公告)日：1976-07-27
申请号：US438744
申请日：1974-02-01
IPC分类号： C07D307/86 , C07D211/22
CPC分类号： C07D307/86 , Y10S514/821 , Y10S514/869 , Y10S514/929
摘要： A compound of the formula ##SPC1##In which R is hydrogen, hydroxy, halogen or alkoxy containing up to 3 carbon atoms, and ##EQU1## is dialkylamino in which the alkyls contain up to 3 carbon atoms, or pyrrolidino, piperidino, morpholino or hexamethyleneimino, and n is 2 or 3. The compounds are prepared by reacting R substituted benzaldehyde with a 2,3-dihydrobenzofuran derivative and then reducing that reaction product. The compounds possess antihypertensive, hypotensive, vasodilatatory, spasmolytic, diuretic, sedative, anti-arythmic and anti-inflammatory properties.
摘要翻译： 式中R为氢，羟基，卤素或至多3个碳原子的烷氧基的化合物，R 1 -N ANGLE R 2为烷基含有最多3个碳原子的二烷基氨基，或吡咯烷基，哌啶子基，吗啉代或六亚甲基亚氨基 ，n为2或3.通过使R取代的苯甲醛与2,3-二氢苯并呋喃衍生物反应然后还原该反应产物来制备化合物。 该化合物具有抗高血压，降血压，血管扩张，解痉，利尿，镇静，抗胂和抗炎等功能。
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公开(公告)号：US3951968A
公开(公告)日：1976-04-20
申请号：US506825
申请日：1974-09-17
IPC分类号： C07D498/12 , C07D235/12 , C07D498/18 , C07D265/00 , C07D273/00 , C07D295/00
CPC分类号： C07D235/12 , Y10S148/067 , Y10S514/869 , Y10S514/87 , Y10S514/927
摘要： Compounds having the formula ##SPC1##Wherein Y is an aliphatic radical having up to 4 carbon atoms, phenyl, or phenyl substituted by one or more halogens, aliphatic radical having up to 4 carbon atoms, methoxy or trifluoromethyl.The compounds are prepared by reacting epichlorohydrin with benzimidazole substituted at the 2 position by ##EQU1## The compounds possess diuretic, sedative, antiulcerous, analgesic, antiinflammatory and cardiac analeptic properties.
摘要翻译： 具有式WHEREIN Y的化合物是具有至多4个碳原子的脂族基团，苯基或被一个或多个卤素取代的苯基，具有至多4个碳原子的脂族基团，甲氧基或三氟甲基。
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公开(公告)号：US3962256A
公开(公告)日：1976-06-08
申请号：US481273
申请日：1974-06-20
IPC分类号： C07D233/04 , C07D235/10 , C07D235/14 , C07D401/06
CPC分类号： C07D235/10 , C07D235/14 , Y10S514/821 , Y10S514/826 , Y10S514/869 , Y10S514/929
摘要： Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.
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