Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene glycol (PEG) ester, and uses thereof
    1.
    发明授权
    Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene glycol (PEG) ester, and uses thereof 有权
    包含至少一种两亲性脂质,至少一种油和至少一种聚乙二醇(PEG)酯的纳米乳剂及其用途

    公开(公告)号:US06562356B2

    公开(公告)日:2003-05-13

    申请号:US09765564

    申请日:2001-01-22

    IPC分类号: A61K600

    摘要: Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol (PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I): R1—(O—CH2—CH2)n—OR2  (I) in which: R1 is chosen from linear and branched, saturated and unsaturated alkyl groups comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl groups comprising from 8 to 30 carbon atoms, R2 is chosen from a hydrogen atom, linear and branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, and n is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.

    摘要翻译: 水包油纳米乳剂,其包含平均尺寸小于150nm的油球,并且包含至少一种油,至少一种两亲脂质和至少一种选自PEG酯和PEG醚的聚乙二醇(PEG)衍生物,所述聚乙二醇(PEG)衍生物选自 式(I)化合物:其中:R1选自包含8至30个碳原子的直链和支链,饱和和不饱和的烷基和包含8至30个碳原子的直链和支链,饱和和不饱和的酰基,R2是 选自氢原子,包含1至30个碳原子的直链和支链,饱和和不饱和烷基,以及包含1至30个碳原子的直链和支链,饱和和不饱和的酰基,n为80至350的数 包含这种水包油纳米乳剂的方法。

    Nanoemulsion containing nonionic polymers, and its uses
    5.
    发明授权
    Nanoemulsion containing nonionic polymers, and its uses 失效
    含有非离子聚合物的纳米乳液及其用途

    公开(公告)号:US06998426B2

    公开(公告)日:2006-02-14

    申请号:US09903768

    申请日:2001-07-13

    IPC分类号: A61K31/74 A61K9/107

    摘要: These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1–C2 alkyl celluloses and their derivatives; C1–C3 alkyl guar; C1–C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.

    摘要翻译: 这些目的和其它目的可以用本发明来完成,本发明的第一个实施例提供了一种水包油纳米乳液,其中包括

    Nanoemulsion containing nonionic polymers, and its uses
    6.
    发明申请
    Nanoemulsion containing nonionic polymers, and its uses 审中-公开
    含有非离子聚合物的纳米乳液及其用途

    公开(公告)号:US20060030655A1

    公开(公告)日:2006-02-09

    申请号:US11248285

    申请日:2005-10-13

    IPC分类号: C08K5/10 B60C1/00

    摘要: These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1-C2 alkyl celluloses and their derivatives; C1-C3 alkyl guar; C1-C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.

    摘要翻译: 这些目的和其它目的可以用本发明来完成,本发明的第一个实施方案提供了一种水包油纳米乳液,其包括:分散在水相中的油相; (i)至少一种选自包括非离子两亲性脂质,阴离子两亲性脂质及其组合的两亲性脂质; 和(ii)至少一种选自包括环氧乙烷的均聚物和共聚物的水溶性非离子聚合物; 聚乙烯醇; 乙烯基吡咯烷酮的均聚物和共聚物; 乙烯基己内酰胺的均聚物和共聚物; 聚乙烯基甲基醚的均聚物和共聚物; 中性丙烯酸均聚物和共聚物; C 1 -C 2烷基纤维素及其衍生物; C 1 -C 3烷基瓜尔胶; C 1 -C 3羟烷基瓜尔胶; 及其组合; 其中所述油相的重量与所述两亲脂质(i)的重量的比率为1.2至10; 并且其中所述油相包括数均分子量小于100nm的油球。 获得的纳米乳液优选在储存时是透明的和稳定的。 它可以形成用于局部,优选化妆品或皮肤病学组合物,药物组合物和眼科学组合物的组合物。

    SUNSCREEN COMPOSITIONS HAVING SYNERGISTIC COMBINATION OF UV FILTERS
    10.
    发明申请
    SUNSCREEN COMPOSITIONS HAVING SYNERGISTIC COMBINATION OF UV FILTERS 有权
    具有紫外线过滤器的协同组合的SUNSCREEN组合物

    公开(公告)号:US20130129650A1

    公开(公告)日:2013-05-23

    申请号:US13304202

    申请日:2011-11-23

    IPC分类号: A61K8/37 A61Q17/04

    摘要: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high overall amounts of UV filtering agents, and without requiring the use of oxybenzone. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.

    摘要翻译: 本公开涉及具有提供高防晒因子(SPF)的紫外线(UV)过滤剂的协同组合的防晒组合物。 根据本公开的组合物具有高的SPF值,而不需要高量的UV过滤剂,并且不需要使用羟基苯酮。 此外,本公开涉及使用所述组合物从紫外线辐射中保护角质物质如皮肤和毛发的方法。