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13 条记录 (耗时 0.041 秒)

    Ultrasound device for axial ranging
    1.
    发明授权
    Ultrasound device for axial ranging 失效

    公开(公告)号：US6024703A

    公开(公告)日：2000-02-15

    申请号：US852977

    申请日：1997-05-07

    申请人： Claudio I. Zanelli ,  Jeffrey J. Giba ,  Michael A. Davis ,  Douglas Murphy-Chutorian

    发明人： Claudio I. Zanelli ,  Jeffrey J. Giba ,  Michael A. Davis ,  Douglas Murphy-Chutorian

    IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/20 ,  A61B18/24 ,  A61B8/00

    CPC分类号： A61B18/20 ,  A61B18/24 ,  A61B2017/00106 ,  A61B2017/00247 ,  A61B2017/22072 ,  A61B2018/00392 ,  A61B2018/00636

    摘要： A treatment tool such as a catheter, MIS or other surgical tool apparatus for placement within a heart chamber, organ aperture or other body opening and axial ranging therein, the apparatus particularly adapted for laser-assisted percutaneous transmyocardial revascularization (MTR). At the distal end of the tool is an annular ultrasound transducer with associated structure, positioned to transmit ultrasound signals substantially axially aligned with the axis of the treatment tool to the cardiovascular tissue, the transducer further receiving returning signals from the cardiovascular tissue to be treated. In a preferred embodiment, the transducer comprises a piezoelectric crystal material. The transducer assembly is attached to the distal tip of the tool such that a laser delivery means or other functional device can be extended through the lumen of the tool and the annular ultrasound transducer. In a preferred embodiment, the invention is a modular ultrasound device capable of being detachably attached to a steerable catheter, MIS or other surgical tool apparatus. The system also comprises a signal interface extending from the ultrasound transducer and signal processing component operatively connected to the signal interface for real time determination of at least one boundary surface of cardiovascular tissue relative to one or more positions of the distal tip of the treatment tool. A method of delivering laser energy to tissue is disclosed, the method including the steps of positioning the firing tip of a laser delivery means adjacent the front surface of the tissue, delivering laser energy to the tissue, transmitting ultrasound energy to the tissue, receiving ultrasound signals reflected from at least the rear surface of the tissue, and determining the distance betwveen the firing tip of the laser delivery means and the rear surface of the tissue. In a preferred embodiment, the method includes quantitative determination of the contractility or motion of the beating heart, such that changes in the depth of tissue can be used to control the channel depth or other treatment parameters. Retrolasing can also be achieved by mechanically piercing the tissue to a determined depth based on axial ranging measurements, and retracting the treatment tool while simultaneously delivering laser energy therefrom.

    Method for non-synchronous laser-assisted myocardial revascularization
    2.
    发明授权
    Method for non-synchronous laser-assisted myocardial revascularization 失效

    公开(公告)号：US5931834A

    公开(公告)日：1999-08-03

    申请号：US904222

    申请日：1997-07-31

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Jeffrey J. Giba ,  Mark Roush ,  Fred G. Kinley

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Jeffrey J. Giba ,  Mark Roush ,  Fred G. Kinley

    IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B18/24 ,  A61B17/36

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2017/00703 ,  A61B2018/00392

    摘要： A method of selecting laser parameters for performing laser-assisted myocardial revascularization to avoid inducing undesired cardiac arrhythmia without synchronization of delivery of laser energy and the patient's cardiac cycle, the method comprising the steps of minimizing the power level of laser energy used, thereby decreasing the overall trauma to the heart, selecting a pulse frequency as great as possible while avoiding adverse summation effects, selecting a pulse width as wide as possible to prevent excessively high peak powers per pulse and not so wide as to cause undesired thermal damage, selecting an energy flux rate, shaping the front end of each pulse of laser energy to provide efficient, non-explosive TMR channeling, and correcting the selected power level, pulse width, pulse frequency and energy flux rate for mechanical events, including method of access to the heart, position of selected portions of myocardium in the heart, temporal duration of the procedure, natural movement of the heart, specific heart geometry, pre-existing heart arrhythmia and other factors causing a predisposition to heart arrhythmia. A method for performing laser-assisted transmyocardial revascularization (TMR) and percutaneous transluminal myocardial revascularization (PTMR) using such laser energy with parameters selected to avoid inducing undesired cardiac arrhythmia, the method comprising the steps of generating laser energy having a predetermined non-square wave shape, a predetermined wavelength, a predetermined energy flux and a predetermined power level, and delivering the laser energy in a plurality of pulses, the plurality of pulses having a predetermined pulse frequency and a predetermined pulse width, to selected portions of myocardium to form TMR and PTMR channels without synchronizing delivery of the laser beam with the cardiac cycle.

    Intraoperative myocardial device and stimulation procedure
    4.
    发明授权
    Intraoperative myocardial device and stimulation procedure 失效
    术中心肌装置及刺激程序

    公开(公告)号：US06620153B2

    公开(公告)日：2003-09-16

    申请号：US09854072

    申请日：2001-05-11

    申请人： Richard L. Mueller ,  Douglas Murphy-Chutorian ,  Stuart D. Harman

    发明人： Richard L. Mueller ,  Douglas Murphy-Chutorian ,  Stuart D. Harman

    IPC分类号： A61G1820

    CPC分类号： A61B18/24 ,  A61B2017/00172 ,  A61B2017/00247 ,  A61B2017/22074 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61B2018/208

    摘要： An apparatus for stimulating revascularization of myocardium tissue in the ventricular wall of a human heart is disclosed. The apparatus includes means for moving the distal end of an optical fiber element forwardly through the epicardium of the heart and into the myocardium and emitting relatively low power bursts of laser energy from the distal end to form stimulus injury zones that promote capillary growth and tissue revascularization. Each penetration of the optical fiber element may produce multiple stimulus zones spaced radially from or in line with the axis of the optical fiber element. Apparatus for moving the optical fiber element and controlling the laser emissions in a predetermined manner is also disclosed.

    摘要翻译： 公开了一种用于刺激人心脏心室壁心肌组织血运重建的装置。 该装置包括用于将光纤元件的远端向前移动通过心脏心外膜并进入心肌的装置，并且从远端发射相对低功率的激光能量脉冲以形成促进毛细血管生长和组织血运重建的刺激性损伤区域 。 光纤元件的每次穿透可以产生与光纤元件的轴线径向间隔开或与光纤元件的轴线成间隔的多个刺激区域。 还公开了用于移动光纤元件并以预定方式控制激光发射的装置。

    Laser delivery means adapted for drug delivery
    5.
    发明授权
    Laser delivery means adapted for drug delivery 失效
    用于药物输送的激光输送装置

    公开(公告)号：US5999678A

    公开(公告)日：1999-12-07

    申请号：US773430

    申请日：1996-12-27

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    IPC分类号： A61B17/00 ,  A61B18/24 ,  G02B6/06 ,  A61B17/36 ,  A61M31/00

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing a predetermined amount of one or more drugs into a laser created opening in the human body, the apparatus consisting of a laser delivery means such as an optical fiber or fiber bundle, a drug conduit which transfers the one or more drugs, drug solutions or other substances to the distal end of the laser delivery means, and the laser delivery means disposed essentially coaxially with the drug conduit. Laser delivery means is used to create a TMR channel or other opening in the body. Dispensed drug or other substance travels through the drug conduit and emanates from the drug conduit to be delivered into the TMR channel or other laser created opening. Drug is dispensed by manually or automatically activating an electric motor which actuates a piston element. A method of use is also disclosed.

    摘要翻译： 一种用于将预定量的一种或多种药物分配到人体内的激光产生开口中的药物输送装置，该装置由诸如光纤或纤维束的激光输送装置组成，药物导管将一个或多个 药物，药物溶液或其它物质，并且激光输送装置基本上与药物导管同轴地设置。 激光输送装置用于在体内产生TMR通道或其他开口。 分配的药物或其他物质通过药物导管，并从药物导管发出，以被输送到TMR通道或其他激光产生的开口中。 药物通过手动或自动激活致动活塞元件的电动机来分配。 还公开了一种使用方法。

    Laser assisted drug delivery
    8.
    发明授权
    Laser assisted drug delivery 失效
    激光辅助药物输送

    公开(公告)号：US5925012A

    公开(公告)日：1999-07-20

    申请号：US773872

    申请日：1996-12-27

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Robert Lincoln Lathrop, III ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Robert Lincoln Lathrop, III ,  Bruce Richardson

    IPC分类号： A61B17/00 ,  A61B18/24 ,  A61M1/00

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.

    摘要翻译： 用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针 用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。 药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。 可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。 通过手动或自动启动活塞或注射器元件来分配药物。 还公开了一种使用方法。

    Laser assisted drug delivery
    10.
    发明授权
    Laser assisted drug delivery 失效
    激光辅助药物输送

    公开(公告)号：US06706011B1

    公开(公告)日：2004-03-16

    申请号：US09288251

    申请日：1999-04-08

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    IPC分类号： A61M3100

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.

    摘要翻译： 用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针 用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。 药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。 可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。 通过手动或自动启动活塞或注射器元件来分配药物。 还公开了一种使用方法。