利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

64 条记录 (耗时 0.059 秒)

    Laser assisted drug delivery
    1.
    发明授权
    Laser assisted drug delivery 失效
    激光辅助药物输送

    公开(公告)号：US5925012A

    公开(公告)日：1999-07-20

    申请号：US773872

    申请日：1996-12-27

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Robert Lincoln Lathrop, III ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Robert Lincoln Lathrop, III ,  Bruce Richardson

    IPC分类号： A61B17/00 ,  A61B18/24 ,  A61M1/00

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.

    摘要翻译： 用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针 用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。 药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。 可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。 通过手动或自动启动活塞或注射器元件来分配药物。 还公开了一种使用方法。

    Laser delivery means adapted for drug delivery
    2.
    发明授权
    Laser delivery means adapted for drug delivery 失效
    用于药物输送的激光输送装置

    公开(公告)号：US5999678A

    公开(公告)日：1999-12-07

    申请号：US773430

    申请日：1996-12-27

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    IPC分类号： A61B17/00 ,  A61B18/24 ,  G02B6/06 ,  A61B17/36 ,  A61M31/00

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing a predetermined amount of one or more drugs into a laser created opening in the human body, the apparatus consisting of a laser delivery means such as an optical fiber or fiber bundle, a drug conduit which transfers the one or more drugs, drug solutions or other substances to the distal end of the laser delivery means, and the laser delivery means disposed essentially coaxially with the drug conduit. Laser delivery means is used to create a TMR channel or other opening in the body. Dispensed drug or other substance travels through the drug conduit and emanates from the drug conduit to be delivered into the TMR channel or other laser created opening. Drug is dispensed by manually or automatically activating an electric motor which actuates a piston element. A method of use is also disclosed.

    摘要翻译： 一种用于将预定量的一种或多种药物分配到人体内的激光产生开口中的药物输送装置，该装置由诸如光纤或纤维束的激光输送装置组成，药物导管将一个或多个 药物，药物溶液或其它物质，并且激光输送装置基本上与药物导管同轴地设置。 激光输送装置用于在体内产生TMR通道或其他开口。 分配的药物或其他物质通过药物导管，并从药物导管发出，以被输送到TMR通道或其他激光产生的开口中。 药物通过手动或自动激活致动活塞元件的电动机来分配。 还公开了一种使用方法。

    Laser assisted drug delivery
    3.
    发明授权
    Laser assisted drug delivery 失效
    激光辅助药物输送

    公开(公告)号：US06706011B1

    公开(公告)日：2004-03-16

    申请号：US09288251

    申请日：1999-04-08

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Steve A. Daniel ,  Larry Witham ,  Bruce Richardson

    IPC分类号： A61M3100

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.

    摘要翻译： 用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针 用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。 药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。 可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。 通过手动或自动启动活塞或注射器元件来分配药物。 还公开了一种使用方法。

    Intraoperative myocardial device and stimulation procedure
    4.
    发明授权
    Intraoperative myocardial device and stimulation procedure 失效
    术中心肌装置及刺激程序

    公开(公告)号：US06620153B2

    公开(公告)日：2003-09-16

    申请号：US09854072

    申请日：2001-05-11

    申请人： Richard L. Mueller ,  Douglas Murphy-Chutorian ,  Stuart D. Harman

    发明人： Richard L. Mueller ,  Douglas Murphy-Chutorian ,  Stuart D. Harman

    IPC分类号： A61G1820

    CPC分类号： A61B18/24 ,  A61B2017/00172 ,  A61B2017/00247 ,  A61B2017/22074 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61B2018/208

    摘要： An apparatus for stimulating revascularization of myocardium tissue in the ventricular wall of a human heart is disclosed. The apparatus includes means for moving the distal end of an optical fiber element forwardly through the epicardium of the heart and into the myocardium and emitting relatively low power bursts of laser energy from the distal end to form stimulus injury zones that promote capillary growth and tissue revascularization. Each penetration of the optical fiber element may produce multiple stimulus zones spaced radially from or in line with the axis of the optical fiber element. Apparatus for moving the optical fiber element and controlling the laser emissions in a predetermined manner is also disclosed.

    摘要翻译： 公开了一种用于刺激人心脏心室壁心肌组织血运重建的装置。 该装置包括用于将光纤元件的远端向前移动通过心脏心外膜并进入心肌的装置，并且从远端发射相对低功率的激光能量脉冲以形成促进毛细血管生长和组织血运重建的刺激性损伤区域 。 光纤元件的每次穿透可以产生与光纤元件的轴线径向间隔开或与光纤元件的轴线成间隔的多个刺激区域。 还公开了用于移动光纤元件并以预定方式控制激光发射的装置。

    Method for non-synchronous laser-assisted myocardial revascularization
    5.
    发明授权
    Method for non-synchronous laser-assisted myocardial revascularization 失效

    公开(公告)号：US5931834A

    公开(公告)日：1999-08-03

    申请号：US904222

    申请日：1997-07-31

    申请人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Jeffrey J. Giba ,  Mark Roush ,  Fred G. Kinley

    发明人： Douglas Murphy-Chutorian ,  Richard L. Mueller ,  Stuart D. Harman ,  Jeffrey J. Giba ,  Mark Roush ,  Fred G. Kinley

    IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B18/24 ,  A61B17/36

    CPC分类号： A61B18/24 ,  A61B2017/00247 ,  A61B2017/00703 ,  A61B2018/00392

    摘要： A method of selecting laser parameters for performing laser-assisted myocardial revascularization to avoid inducing undesired cardiac arrhythmia without synchronization of delivery of laser energy and the patient's cardiac cycle, the method comprising the steps of minimizing the power level of laser energy used, thereby decreasing the overall trauma to the heart, selecting a pulse frequency as great as possible while avoiding adverse summation effects, selecting a pulse width as wide as possible to prevent excessively high peak powers per pulse and not so wide as to cause undesired thermal damage, selecting an energy flux rate, shaping the front end of each pulse of laser energy to provide efficient, non-explosive TMR channeling, and correcting the selected power level, pulse width, pulse frequency and energy flux rate for mechanical events, including method of access to the heart, position of selected portions of myocardium in the heart, temporal duration of the procedure, natural movement of the heart, specific heart geometry, pre-existing heart arrhythmia and other factors causing a predisposition to heart arrhythmia. A method for performing laser-assisted transmyocardial revascularization (TMR) and percutaneous transluminal myocardial revascularization (PTMR) using such laser energy with parameters selected to avoid inducing undesired cardiac arrhythmia, the method comprising the steps of generating laser energy having a predetermined non-square wave shape, a predetermined wavelength, a predetermined energy flux and a predetermined power level, and delivering the laser energy in a plurality of pulses, the plurality of pulses having a predetermined pulse frequency and a predetermined pulse width, to selected portions of myocardium to form TMR and PTMR channels without synchronizing delivery of the laser beam with the cardiac cycle.

    Heart stabilizer with controllable stay suture and cutting element
    6.
    发明授权
    Heart stabilizer with controllable stay suture and cutting element 失效
    心肌稳定器具有可控制的缝合和切割元件

    公开(公告)号：US6015427A

    公开(公告)日：2000-01-18

    申请号：US882774

    申请日：1997-07-07

    申请人： Richard L. Mueller ,  Steve A. Daniel ,  Stuart D. Harman

    发明人： Richard L. Mueller ,  Steve A. Daniel ,  Stuart D. Harman

    IPC分类号： A61B17/02 ,  A61B17/04 ,  A61B17/122 ,  A61B17/00

    CPC分类号： A61B17/02 ,  A61B17/0466 ,  A61B17/0487 ,  A61B17/1227 ,  A61B2017/0243 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496

    摘要： A heart stabilizer and suture control device for stabilizing the heart and for occluding a preselected portion of coronary artery by developing a downward force on the heart and simultaneously developing an upward force across a coronary artery in a predetermined position. The device has at least two stabilization pads, the stabilization pads each having an operative size and shape, and each having a first end and a second end and a lower contacting surface. The second ends have suture retaining grooves, and the stabilization pad has a suture locking means for securing the distal end of a suture means thereto. The device also comprises a linking member locking the two stabilization pads an operative distance apart. The device has suture means with a proximal end coupled to the linking member and extending from the first end to the suture retaining groove of the second end, the suture means having a distal end which can be locked to the stabilization pad with the suture locking means thereon. The device also has means for rotating the linking member such that when operatively positioned adjacent a coronary artery to be occluded with the suture threaded between the coronary artery and the remaining portion of the heart muscle, rotating the linking member will cause the proximal end of the suture means to be wound onto the linking member and thus tighten the suture between the first end and the second end of each stabilization pad and urge the coronary artery against the contacting surface, thereby causing occlusion of the coronary artery as desired.

    摘要翻译： 一种心脏稳定器和缝合线控制装置，用于通过在心脏上产生向下的力同时在预定位置上跨越冠状动脉形成向上的力来稳定心脏并阻塞冠状动脉的预选部分。 该装置具有至少两个稳定垫，稳定垫各自具有可操作的尺寸和形状，并且每个具有第一端和第二端和下接触表面。 第二端具有缝合线保持槽，并且稳定垫具有用于将缝线装置的远端固定到其上的缝合线锁定装置。 该装置还包括连接构件，其将两个稳定垫片间隔开操作距离。 该装置具有缝合装置，其近端联接到连接构件并且从第一端的第一端延伸到缝合线保持槽，缝合线装置具有远端，该远端可利用缝合线锁定装置锁定到稳定垫 上。 该装置还具有用于旋转连接构件的装置，使得当可操作地定位成邻近冠状动脉以被缝合在冠状动脉与心脏肌肉的剩余部分之间的缝合线时，旋转连接构件将导致连接构件的近端 缝合装置被缠绕到连接构件上，从而在每个稳定垫的第一端和第二端之间紧固缝合线，并且迫使冠状动脉抵靠接触表面，从而根据需要引起冠状动脉闭塞。

    Laser device with auto-piercing tip for myocardial revascularization procedures
    10.
    发明授权
    Laser device with auto-piercing tip for myocardial revascularization procedures 失效
    具有自动穿刺尖端的激光装置用于心肌血运重建手术

    公开(公告)号：US6152918A

    公开(公告)日：2000-11-28

    申请号：US58387

    申请日：1998-04-09

    申请人： Henry N. Padilla ,  Richard L. Mueller ,  Stuart D. Harman

    发明人： Henry N. Padilla ,  Richard L. Mueller ,  Stuart D. Harman

    IPC分类号： A61B1/018 ,  A61B1/267 ,  A61B1/313 ,  A61B17/00 ,  A61B17/22 ,  A61B17/34 ,  A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61B18/18

    CPC分类号： A61B17/3403 ,  A61B18/22 ,  A61B18/24 ,  A61B2017/00172 ,  A61B2017/00247 ,  A61B2017/22074 ,  A61B2017/22075 ,  A61B2017/22077 ,  A61B2018/00291 ,  A61B2018/00392 ,  A61B2018/208 ,  A61B90/37

    摘要： The apparatus for combined mechanical/laser myocardial revascularization of a human heart includes: inserting a mechanical piercing device and an elongated flexible lasing apparatus into the chest cavity of a patient; mechanically auto-piercing, micro-tearing or spreading the epicardium of the heart; and then lasing from beneath the epicardium through the myocardium. The apparatus is guided to an area exterior to a ventricle of the patient's heart, and the distal end of the energy delivery device such as an optical fiber apparatus is placed internal to the exterior wall of the heart through an opening which has been created by mechanically piercing, micro-tearing or spreading the epicardium, so that the myocardium and not the epicardium is irradiated with laser energy to allow passage of said energy delivery device such as an optical fiber distal end or said laser energy into the left ventricular cavity without causing a laser irradiation of the epicardium which might be a cause of operative bleeding and for better allowing the sealing of the epicardium after the apparatus is removed. The apparatus includes a hand-held device controllable by the physician having a removable distal head portion with an auto-piercing mechanism and can use a vacuum source to provide a suction force at the head portion. The auto-piercing mechanism is implemented by various ways such as a spring-biased actuating member in the TMR hand-held device and an electro-mechanical operated piercing mechanism. The hand-held TMR device with handle assembly can also be controlled by a computer to provide auto- sequencing of the auto-piercing needle mechanism and the laser firing with auto-fiber advancement.

    摘要翻译： 用于人体心脏联合机械/激光心肌血运重建的装置包括：将机械刺穿装置和细长的柔性激光装置插入患者的胸腔中; 机械自动穿刺，微撕裂或散布心脏的心外膜; 然后通过心肌从心外膜下射出。 该装置被引导到患者心脏的心室的外部区域，并且诸如光纤装置的能量输送装置的远端通过已经通过机械产生的开口放置在心脏的外壁内部 穿透，微裂或扩散心外膜，使得心肌而不是心外膜被激光能量照射，以允许所述能量输送装置如光纤远端或所述激光能量通过到左心室，而不引起 心外膜的激光照射可能是手术出血的原因，并且在移除装置之后更好地允许密封心包膜。 该装置包括由医师控制的手持式装置，其具有带有自动穿孔机构的可拆卸远端头部，并且可以使用真空源在头部提供吸力。 自动穿孔机构通过各种方式实现，例如TMR手持装置中的弹簧偏压致动构件和机电操作的穿孔机构。 具有手柄组件的手持式TMR装置还可以由计算机控制，以提供自动穿刺针机构的自动排序和使用自动纤维前进的激光烧制。