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公开(公告)号：US20240425827A1
公开(公告)日：2024-12-26
申请号：US18822990
申请日：2024-09-03
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20210102179A1
公开(公告)日：2021-04-08
申请号：US17120646
申请日：2020-12-14
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US12110513B2
公开(公告)日：2024-10-08
申请号：US17120646
申请日：2020-12-14
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
CPC classification number: C12N9/1205 , C12Y207/01033
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20220325256A1
公开(公告)日：2022-10-13
申请号：US17711451
申请日：2022-04-01
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Aksiniya Lyubenova Petkova
IPC: C12N9/12
Abstract: The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US12180483B2
公开(公告)日：2024-12-31
申请号：US17711430
申请日：2022-04-01
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Aksiniya Lyubenova Petkova
Abstract: Cyclic GMP-AMP synthase (cGAS) enzymes have been engineered to produce polypeptides having increased cGAS activity in the cyclization of modified nucleoside triphosphates, including thiolated or fluorinated nucleoside triphosphates, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing cGAS enzymes, compositions comprising the cGAS enzymes, and methods of using the engineered cGAS enzymes are useful for the production of pharmaceutical compounds.
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Patent Agency Ranking
公开(公告)号：US20220325285A1
公开(公告)日：2022-10-13
申请号：US17711430
申请日：2022-04-01
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Aksiniya Lyubenova Petkova
Abstract: The present invention provides engineered cyclic GMP-AMP synthase (cGAS) enzymes, polypeptides having cGAS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing cGAS enzymes are also provided. The present invention further provides compositions comprising the cGAS enzymes and methods of using the engineered cGAS enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US10889806B2
公开(公告)日：2021-01-12
申请号：US16460147
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20240150733A1
公开(公告)日：2024-05-09
申请号：US18420071
申请日：2024-01-23
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Aksiniya Lyubenova Petkova
IPC: C12N9/12
CPC classification number: C12N9/1217 , C12Y207/02001
Abstract: The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11913036B2
公开(公告)日：2024-02-27
申请号：US17711451
申请日：2022-04-01
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Aksiniya Lyubenova Petkova
IPC: C12N9/12
CPC classification number: C12N9/1217 , C12Y207/02001
Abstract: The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20200010815A1
公开(公告)日：2020-01-09
申请号：US16460147
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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