公开(公告)号：US20090012546A1

公开(公告)日：2009-01-08

申请号：US12144990

申请日：2008-06-24

申请人： Colleen Stack N'diaye ,  Jeffrey A. Smith ,  Geoffrey A. Orth ,  Michael S. Williams ,  William L. Athas ,  Thomas B. Miller

发明人： Colleen Stack N'diaye ,  Jeffrey A. Smith ,  Geoffrey A. Orth ,  Michael S. Williams ,  William L. Athas ,  Thomas B. Miller

IPC分类号： A61B17/122

CPC分类号： A61F2/04 ,  A61B17/072 ,  A61B2017/00278 ,  A61F2002/044

摘要： A device for treating GERD includes a pair of sections. Each section includes a proximal end portion with an arcuate interior opening, a distal end portion with an arcuate interior opening, an exterior plate portion, and a tapered body portion extending from the proximal end portion to the distal end portion. The pair of sections surround the esophagus at the gastro-esophageal junction thereof and to be secured together to form a tubular housing with a proximal orifice, a distal orifice smaller than the proximal orifice, and a plate adjacent the distal orifice. A portion of the housing adjacent the distal orifice is configured to elastically deform to constrict the esophagus and serve the function of the LES when a force is applied to the plate by the fundus. The proximal end portion of each mating section includes a flange portion configured to be attached to a body cavity wall.

摘要翻译： 用于治疗GERD的装置包括一对部分。 每个部分包括具有弓形内部开口的近端部分，具有弓形内部开口的远端部分，外部板部分和从基端部分延伸到远端部分的锥形主体部分。 一对部分围绕食道在胃食管接合部处，并且被固定在一起以形成具有近端口的管状壳体，小于近端孔口的远端口和邻近远端口的板。 邻近远端口的壳体的一部分构造成弹性变形以收缩食道，并且当通过眼底将力施加到板上时发挥LES的功能。 每个配合部分的近端部分包括构造成附接到体腔壁的凸缘部分。

公开(公告)号：US20090012542A1

公开(公告)日：2009-01-08

申请号：US12144970

申请日：2008-06-24

申请人： Colleen Stack N'diaye ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Michael S. Williams

发明人： Colleen Stack N'diaye ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Michael S. Williams

IPC分类号： A61B17/12

CPC分类号： A61F5/0079 ,  A61B17/12

摘要： Satiation devices for controlling obesity and methods of implanting same are configured to create a small satiation pouch in the proximal portion of the stomach with a narrow passage leading into the lower portion of the stomach. The small satiation pouch is configured to collect a small amount of masticated food from the esophagus and the narrow passage delays emptying of the food from the satiation pouch into the larger part of the stomach, thereby causing a feeling of fullness.

摘要翻译： 用于控制肥胖的饱和装置和植入其的方法被配置成在胃的近端部分中产生具有通向胃下部的窄通道的小的饱食袋。 小饱食袋配置为从食管收集少量咀嚼食物，狭窄的通道将食物从饱食袋排空到胃的较大部分，从而引起饱腹感。

公开(公告)号：US20100023088A1

公开(公告)日：2010-01-28

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/36 ,  A61N7/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US20120221014A1

公开(公告)日：2012-08-30

申请号：US13286217

申请日：2011-11-01

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/05 ,  A61B19/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

公开(公告)号：US20110166482A1

公开(公告)日：2011-07-07

申请号：US13042350

申请日：2011-03-07

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/36 ,  A61N7/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US07925352B2

公开(公告)日：2011-04-12

申请号：US12413495

申请日：2009-03-27

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US08428730B2

公开(公告)日：2013-04-23

申请号：US13286217

申请日：2011-11-01

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

公开(公告)号：US08369954B2

公开(公告)日：2013-02-05

申请号：US13042350

申请日：2011-03-07

申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

公开(公告)号：US08934956B2

公开(公告)日：2015-01-13

申请号：US13281399

申请日：2011-10-25

申请人： Richard A. Glenn ,  Jeffrey A. Smith ,  Geoffrey A. Orth ,  Kevin Holbrook ,  Michael S. Williams

发明人： Richard A. Glenn ,  Jeffrey A. Smith ,  Geoffrey A. Orth ,  Kevin Holbrook ,  Michael S. Williams

IPC分类号： A61B5/04 ,  A61N1/05 ,  A61B5/00 ,  A61B5/042 ,  A61B5/02 ,  A61N1/00

CPC分类号： A61N1/05 ,  A61B5/0422 ,  A61B5/6862 ,  A61N1/057

摘要： An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall. An exemplary anchor includes a first portion having expansion forces sufficient to bias the electrodes against the vessel wall for mapping and chronic stimulation, and a second portion having greater radial expansion forces sufficient to chronically engage the vessel wall once an optimal electrode location has been selected.

摘要翻译： 用于神经调节的血管内电极装置包括可从径向压缩位置扩展到径向扩张位置的锚固件。 引线从锚固体延伸并且具有延伸穿过其的至少一个导体。 柔性电路耦合到锚固件并且包括柔性绝缘衬底，由衬底承载的多个电极和由衬底承载的多个导电迹线，每个迹线电耦合到电极和导体。 在血管内锚固体的膨胀将电极偏置成与周围的血管壁接触。 示例性的锚包括具有足以将电极偏压抵靠血管壁进行映射和慢性刺激的膨胀力的第一部分，以及一旦已经选择最佳电极位置，具有足以长期接合血管壁的较大径向膨胀力的第二部分。

公开(公告)号：US20120116286A1

公开(公告)日：2012-05-10

申请号：US13353258

申请日：2012-01-18

申请人： Michael S. Williams ,  Daniel W. Fifer ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  William L. Athas ,  Richard S. Stack

发明人： Michael S. Williams ,  Daniel W. Fifer ,  Geoffrey A. Orth ,  Jeffrey A. Smith ,  Richard A. Glenn ,  William L. Athas ,  Richard S. Stack

IPC分类号： A61F2/04

CPC分类号： A61F5/0036 ,  A61F2/04 ,  A61F2/07 ,  A61F2/95 ,  A61F5/0076 ,  A61F5/0089 ,  A61F2002/044 ,  A61F2002/045

摘要： An intestinal implant includes a proximal anchor self-expandable from a radially compressed position to a radially expandable position for engagement with a wall of the intestinal lumen and a flexible sleeve coupled to the anchor. The sleeve is implanted with the anchor downstream from the pylorus and the sleeve extending further downstream through the intestinal lumen.

摘要翻译： 肠植入物包括从径向压缩位置到径向可扩张位置的可自膨胀的近端锚固件，用于与肠腔的壁接合，以及联接到锚的柔性套管。 套管被植入幽门下游的锚固件，并且套筒在下游延伸穿过肠腔。