公开(公告)号：US20230364215A1

公开(公告)日：2023-11-16

申请号：US18029640

申请日：2021-10-01

Applicant: Colorado State University Research Foundation

Inventor： Ramond P. Goodrich ,  Richard Bowen ,  Marcela Henao-Tamayo

IPC: A61K39/04 ,  A61K41/17 ,  A61P31/06 ,  A61K35/74

CPC classification number: A61K39/04 ,  A61K41/17 ,  A61P31/06 ,  A61K35/74 ,  A61K2039/521

Abstract: Provided herein are methods for inactivating a microbe, the methods comprising contacting the microbe with UV light in the presence of riboflavin. In some embodiments, the microbe is a Mycobacterium tuberculosis. Vaccine compositions comprising inactivated microbes, and methods of use thereof, are also provided.

公开(公告)号：US20230346915A1

公开(公告)日：2023-11-02

申请号：US17905700

申请日：2021-03-05

Applicant: Colorado State University Research Foundation

Inventor： Raymond P. Goodrich ,  Richard Bowen

IPC: A61K39/39 ,  A61P31/14 ,  A61K39/215

CPC classification number: A61K39/215 ,  A61K39/39 ,  A61P31/14 ,  A61K2039/5252

Abstract: Provided herein are methods for inactivating a viral particle, the methods comprising contacting the viral particle with UV light in the presence of riboflavin. In some embodiments, the viral particle is a SARS-CoV-2 particle. Vaccine compositions comprising inactivated viral particles (e.g., inactivated SARS-CoV-2 particles) are also provided. In some embodiments, the vaccine compositions comprise an adjuvant capable of promoting a Th1-type immune response.