公开(公告)号：US20230346915A1

公开(公告)日：2023-11-02

申请号：US17905700

申请日：2021-03-05

Applicant: Colorado State University Research Foundation

Inventor： Raymond P. Goodrich ,  Richard Bowen

IPC: A61K39/39 ,  A61P31/14 ,  A61K39/215

CPC classification number: A61K39/215 ,  A61K39/39 ,  A61P31/14 ,  A61K2039/5252

Abstract: Provided herein are methods for inactivating a viral particle, the methods comprising contacting the viral particle with UV light in the presence of riboflavin. In some embodiments, the viral particle is a SARS-CoV-2 particle. Vaccine compositions comprising inactivated viral particles (e.g., inactivated SARS-CoV-2 particles) are also provided. In some embodiments, the vaccine compositions comprise an adjuvant capable of promoting a Th1-type immune response.

公开(公告)号：US20230372555A1

公开(公告)日：2023-11-23

申请号：US17913528

申请日：2021-03-24

Applicant: Colorado State University Research Foundation

Inventor： Bryan D. Willson ,  Raymond P. Goodrich ,  John C. Mizia ,  Matthew R. Willman

IPC: A61L2/00 ,  A61L2/10

CPC classification number: A61L2/0047 ,  A61L2/10 ,  A61L2202/22

Abstract: A device for emitting photons into a fluid is disclosed. The device includes a fluid channel configured to transfer the fluid from an inlet to an outlet thereof and the fluid channel having a helical pathway wound about a longitudinal axis. The device also includes at least one inner light source adjacent the fluid channel, the at least one inner light source positioned between the fluid channel and the longitudinal axis and at least one outer light source adjacent the fluid channel, the fluid channel positioned between the outer light source and the longitudinal axis.