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1.发明授权Bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors 失效双氮杂吲哚衍生物，其作为激酶抑制剂的制备和药物用途公开(公告)号：US07786114B2
公开(公告)日：2010-08-31
申请号：US11692321
申请日：2007-03-28
IPC分类号： A61K31/535 , A61K31/44 , A61K31/497 , C07D401/00 , C07D413/00
CPC分类号： C07D519/00
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
摘要翻译： 式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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2.发明申请NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS 失效新型吡咯（2,3-b）吡啶衍生物，其在激酶抑制剂形式中的制备及其药物应用公开(公告)号：US20090233956A1
公开(公告)日：2009-09-17
申请号：US12410135
申请日：2009-03-24
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A61K31/437 , C07D401/14
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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3.发明授权Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07968566B2
公开(公告)日：2011-06-28
申请号：US12410135
申请日：2009-03-24
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： C07D401/14 , A61K31/437
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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4.发明申请Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效新型吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US20070093480A1
公开(公告)日：2007-04-26
申请号：US11541051
申请日：2006-09-29
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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5.发明授权Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07528147B2
公开(公告)日：2009-05-05
申请号：US11541051
申请日：2006-09-29
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Rommé , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Rommé , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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公开(公告)号：US20070238734A1
公开(公告)日：2007-10-11
申请号：US11608977
申请日：2006-12-11
IPC分类号： A61K31/495 , A61P35/00
CPC分类号： A61K31/495
摘要： The present invention concerns compounds of general formula (I): in which the substituents are as described herein.
摘要翻译： 本发明涉及通式（I）的化合物：其中取代基如本文所述。
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7.发明授权Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology 失效吲唑或吲哚衍生物及其在人类药物中的用途，更具体地在肿瘤学中的应用公开(公告)号：US07119115B2
公开(公告)日：2006-10-10
申请号：US10761982
申请日：2004-01-21
申请人： Michel Tabart , Eric Bacqué , Sylvie Wentzler , Cécile Combeau , Conception Nemecek , Patrick Mailliet , Fabienne Thompson
发明人： Michel Tabart , Eric Bacqué , Sylvie Wentzler , Cécile Combeau , Conception Nemecek , Patrick Mailliet , Fabienne Thompson
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D209/36 , C07D209/44 , C07D413/04
摘要： The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable carrier and a compound of formula (1) or formula (2)
摘要翻译： 本发明涉及衍生自式（1）或式（2）的吲唑或吲哚的新化合物，涉及用式（1）或式（2）化合物治疗肿瘤或癌细胞的方法和药物组合物， 可接受的载体和式（1）或式（2）的化合物
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8.发明申请DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS 审中-公开6-（6-NH-取代的三唑基亚氨基 - 磺酰基）苯并噻唑和苯并咪唑的衍生物，其制备方法及其作为药物的用途，以及作为抑制剂的用途公开(公告)号：US20120040987A1
公开(公告)日：2012-02-16
申请号：US13147297
申请日：2010-02-04
IPC分类号： A61K31/5025 , C07D277/82 , A61P35/00 , A61P21/00 , A61P3/10 , A61P17/06 , A61P27/02 , A61P19/02 , A61P25/00 , A61P11/06 , A61P7/02 , A61P3/00 , A61P37/08 , A61P35/04 , C07D487/04
CPC分类号： C07D277/82 , C07D487/04
摘要： The invention relates to novel products of the formula (I) where: (II) is a single or double bond; Rb is a hydrogen or fluorine atom; Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical; X is S, SO, or SO2; A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; —O— (CH2)n-phenyl with n=1 to 4; or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH; all of said radicals being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
摘要翻译： 本发明涉及式（I）的新产物，其中：（II）是单键或双键; Rb是氢或氟原子; R a是NH-R c基团，其中R c是任选取代的杂环烷基，芳基，杂芳基或 - 烷基环烷基; X是S，SO或SO 2; A是NH或S; W是H，烷基或COR，其中R是环烷基; 烷基; 烷氧基 O-苯基; -O-（CH 2）n - 苯基，n = 1〜4; 或NR1R2，其中R1是H或alk，R2是H，环烷基或烷基; 或R 1，R 2与任选地含有O，S，N和/或NH的N一起形成一个循环; 所有这些基团任选被取代; 其中所述产物可以是任何异构体或盐形式，并且可以用作药物，特别是作为MET抑制剂。
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9.发明申请NOVEL TRIAZOLO(4,3-A)PYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS 审中-公开新型三唑（4,3-A）吡啶衍生物，其制备方法，作为药物，药物组合物和新药使用，特别是作为抑制剂公开(公告)号：US20110263594A1
公开(公告)日：2011-10-27
申请号：US13054663
申请日：2009-07-16
IPC分类号： A61K31/437 , C07D413/14 , A61K31/5377 , A61P9/00 , A61P7/04 , A61P3/00 , A61P37/00 , A61P11/06 , A61P7/02 , A61P25/00 , A61P9/10 , A61P17/06 , A61P29/00 , A61P3/10 , A61P21/00 , A61P35/00 , A61P35/04 , C07D471/04
CPC分类号： A61K31/428 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D471/04
摘要： The invention relates to the novel products of formula (I): in which: Ra represents H, Hal, aryl or heteroaryl, which is optionally substituted; Rb represents H, Rc, —COORc-CO-Rc or —CO—NRcRd; where Rc represents alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd represents H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
摘要翻译： 本发明涉及式（I）的新产物：其中：R a表示任选取代的H，Hal，芳基或杂芳基; Rb表示H，Rc，-COORc-CO-Rc或-CO-NRcRd; 其中R c代表烷基，环烷基，杂环烷基，芳基和杂芳基，全部任意取代; Rd表示H，烷基或环烷基; 这些产品是所有异构体形式和盐，作为药物，特别是作为MET抑制剂。
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10.发明授权6-aryl/heteroalkyloxy benzothiazole and benzimidazole derivatives, method for preparing same, application thereof as drugs, pharmaceutical compositions and novel use in particular as C-MET inhibitors 失效6-芳基/杂烷氧基苯并噻唑和苯并咪唑衍生物，其制备方法，作为药物的用途，药物组合物和特别用作C-MET抑制剂的新用途公开(公告)号：US08188078B2
公开(公告)日：2012-05-29
申请号：US12761973
申请日：2010-04-16
IPC分类号： A61K31/535 , C07D417/12 , C07D277/82
CPC分类号： C07D235/30 , C07D235/32 , C07D277/82 , C07D417/12
摘要： The disclosure relates to compounds of formula (I): wherein A, W, R, R5, and R6 are as defined in the disclosure, or a salt thereof, and to their use as drugs, in particular as c-Met inhibitors.
摘要翻译： 本公开涉及式（I）的化合物：其中A，W，R，R 5和R 6如本公开内容中所定义，或其盐，以及它们作为药物，特别是作为c-Met抑制剂的用途。
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