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1.发明授权Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology 失效吲唑或吲哚衍生物及其在人类药物中的用途，更具体地在肿瘤学中的应用公开(公告)号：US07119115B2
公开(公告)日：2006-10-10
申请号：US10761982
申请日：2004-01-21
申请人： Michel Tabart , Eric Bacqué , Sylvie Wentzler , Cécile Combeau , Conception Nemecek , Patrick Mailliet , Fabienne Thompson
发明人： Michel Tabart , Eric Bacqué , Sylvie Wentzler , Cécile Combeau , Conception Nemecek , Patrick Mailliet , Fabienne Thompson
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D209/36 , C07D209/44 , C07D413/04
摘要： The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable carrier and a compound of formula (1) or formula (2)
摘要翻译： 本发明涉及衍生自式（1）或式（2）的吲唑或吲哚的新化合物，涉及用式（1）或式（2）化合物治疗肿瘤或癌细胞的方法和药物组合物， 可接受的载体和式（1）或式（2）的化合物
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![SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO [3,4-C]PYRIDINES COMPOSITIONS COMPRISING THEM, AND USE](/abs-image/US/2006/09/07/US20060199837A1/abs.jpg.150x150.jpg)
2.发明申请SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO [3,4-C]PYRIDINES COMPOSITIONS COMPRISING THEM, AND USE 失效取代的四氢-1H-吡唑并[3,4-C]吡啶类化合物及其用途公开(公告)号：US20060199837A1
公开(公告)日：2006-09-07
申请号：US11419794
申请日：2006-05-23
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use](/abs-image/US/2008/10/14/US07435820B2/abs.jpg.150x150.jpg)
3.发明授权Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use 失效包含它们的取代的四氢-1H-吡唑并[3,4-c]吡啶组合物，并使用公开(公告)号：US07435820B2
公开(公告)日：2008-10-14
申请号：US11419794
申请日：2006-05-23
申请人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
发明人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use](/abs-image/US/2006/09/19/US07109340B2/abs.jpg.150x150.jpg)
4.发明授权Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物，并使用公开(公告)号：US07109340B2
公开(公告)日：2006-09-19
申请号：US10888611
申请日：2004-07-09
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use](/abs-image/US/2005/05/05/US20050096345A1/abs.jpg.150x150.jpg)
5.发明申请Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物，并使用公开(公告)号：US20050096345A1
公开(公告)日：2005-05-05
申请号：US10888611
申请日：2004-07-09
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号： A61P35/00 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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6.发明授权Compounds derived from oxindoles and their therapeutic application in cancer treatment 失效衍生自羟吲哚的化合物及其在癌症治疗中的应用公开(公告)号：US06930124B2
公开(公告)日：2005-08-16
申请号：US10659094
申请日：2003-09-10
IPC分类号： A61P35/00 , C07D403/06 , A61K31/4015 , A61K31/404 , C07D209/04
CPC分类号： C07D403/06
摘要： The invention relates to compounds of formula (I) in which R5 is chosen from the group consisting of: in which R2 is a C1-C3 alkyl group in which X may be Cl, Br, or F in which n is between 1 and 3, in the E or Z form, or a mixture of the two isomeric forms, possessing antimitotic, antiproliferative and antivascular properties through inhibition of the polymerization of tubulin into microtubules
摘要翻译： 本发明涉及式（I）化合物，其中R 5选自由以下组成的组：其中R 2为C 1
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7.发明授权Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 有权芴衍生物，含有该衍生物的组合物及其作为蛋白质分子伴侣HSP90抑制剂的用途公开(公告)号：US08163750B2
公开(公告)日：2012-04-24
申请号：US12625005
申请日：2009-11-24
申请人： Fabienne Thompson , Patrick Mailliet , Jean-Marie Ruxer , Helene Goulaouic , Francois Vallee , Herve Minoux , Fabienne Pilorge , Luc Bertin , Stephane Hourcade , Maria Mendez-Perez , Peter Hamley
发明人： Fabienne Thompson , Patrick Mailliet , Jean-Marie Ruxer , Helene Goulaouic , Francois Vallee , Herve Minoux , Fabienne Pilorge , Luc Bertin , Stephane Hourcade , Maria Mendez-Perez , Peter Hamley
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D403/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R1, R2, R2′, L, Het, p and p′ are as defined herein, compositions containing them, and their use as medicinal products.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R2'，L，Het，p和p'如本文所定义，含有它们的组合物及其作为药用产品的用途。
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8.发明申请N-arylheteroaromatic products compositions containing them and use thereof 审中-公开含有它们的N-芳基异芳香族产物组合物及其用途公开(公告)号：US20050130989A1
公开(公告)日：2005-06-16
申请号：US10764653
申请日：2004-01-26
IPC分类号： C07D207/34 , C07D231/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , A61K31/496 , C07D43/02
CPC分类号： C07D401/04 , C07D207/34 , C07D231/14 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04
摘要： N-Arylheteroaromatic products, compositions containing them and use thereof. The present invention relates to novel chemical compounds, particularly to novel N-arylheteroaromatic products, to compositions containing them and to their use as medicinal products, in particular in oncology.
摘要翻译： N-芳基芳香族产物，含有它们的组合物及其用途。 本发明涉及新颖的化合物，特别是涉及新的N-芳基异芳香族产物，含有它们的组合物以及它们作为医药产品，特别是在肿瘤学中的用途。
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9.发明授权Fluorene derivatives, composition containing said derivatives and the use thereof 有权芴衍生物，含有所述衍生物的组合物及其用途公开(公告)号：US07674795B2
公开(公告)日：2010-03-09
申请号：US11939735
申请日：2007-11-14
申请人： Patrick Mailliet , Luc Bertin , Fabienne Thompson , Jean-Marie Ruxer , Fabienne Pilorge , Didier Benard , Hervé Minoux , Chantal Carrez , Hélène Goulaouic , Thierry Gouyon
发明人： Patrick Mailliet , Luc Bertin , Fabienne Thompson , Jean-Marie Ruxer , Fabienne Pilorge , Didier Benard , Hervé Minoux , Chantal Carrez , Hélène Goulaouic , Thierry Gouyon
IPC分类号： A61K31/497 , C07D471/04 , C07D401/10 , A61K31/501 , A61P3/10 , A61P35/00 , C07D239/02 , A61K31/437
CPC分类号： C07D471/04 , C07D401/12
摘要： This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.
摘要翻译： 本发明涉及4-（苯并咪唑-2-基）芴和4-（氮杂苯并咪唑-2-基）芴衍生物，包含这些衍生物的药物组合物，以及治疗与Hsp90蛋白活性有关的病症的方法，包括施用 这样的衍生品。
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10.发明申请公开(公告)号：US20050014765A1
公开(公告)日：2005-01-20
申请号：US10859740
申请日：2004-06-03
IPC分类号： C07D207/34 , C07D233/90 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/06 , C07D401/12 , C07D417/06 , A61K31/496 , A61K31/4439 , C07D413/02
CPC分类号： C07D263/34 , C07D207/34 , C07D233/90 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/06 , C07D401/12 , C07D417/06
摘要： Aryl-heteroaromatic products, compositions comprising them and use. The present invention relates to novel chemical compounds, particularly to novel aryl-heteroaromatic products, to compositions comprising them, and to their use as medicaments, in particular in oncology.
摘要翻译： 芳基杂芳族产物，包含它们的组合物和用途。 本发明涉及新颖的化合物，特别是新颖的芳基杂芳族产物，包含它们的组合物，以及它们作为药物，特别是在肿瘤学中的用途。
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