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1.发明授权Bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors 失效双氮杂吲哚衍生物，其作为激酶抑制剂的制备和药物用途公开(公告)号：US07786114B2
公开(公告)日：2010-08-31
申请号：US11692321
申请日：2007-03-28
IPC分类号： A61K31/535 , A61K31/44 , A61K31/497 , C07D401/00 , C07D413/00
CPC分类号： C07D519/00
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
摘要翻译： 式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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2.发明申请NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS 失效新型吡咯（2,3-b）吡啶衍生物，其在激酶抑制剂形式中的制备及其药物应用公开(公告)号：US20090233956A1
公开(公告)日：2009-09-17
申请号：US12410135
申请日：2009-03-24
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A61K31/437 , C07D401/14
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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3.发明授权Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07968566B2
公开(公告)日：2011-06-28
申请号：US12410135
申请日：2009-03-24
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： C07D401/14 , A61K31/437
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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4.发明申请Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效新型吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US20070093480A1
公开(公告)日：2007-04-26
申请号：US11541051
申请日：2006-09-29
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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5.发明授权Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07528147B2
公开(公告)日：2009-05-05
申请号：US11541051
申请日：2006-09-29
申请人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Rommé , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Rommé , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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6.发明申请Substituted Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors 审中-公开取代的环状尿素衍生物，其制备方法及其药物用途作为激酶抑制剂公开(公告)号：US20080021029A1
公开(公告)日：2008-01-24
申请号：US11627515
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Jacques Mauger , Stefan Guessregen , Kurt Ritter , Jean-Luc Malleron
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Jacques Mauger , Stefan Guessregen , Kurt Ritter , Jean-Luc Malleron
IPC分类号： A61K31/506 , A61K31/4709 , A61K31/5377 , A61P11/06 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P3/00 , A61P3/10 , A61P35/00 , A61P37/08 , A61P7/00 , C07D215/58 , C07D401/02 , C07D413/14 , C12N9/99
CPC分类号： C07D401/06 , C07D409/14
摘要： The disclosure relates to the novel compounds of formula (I): wherein R1, R2, R2′, R3, R3′, p, A, B, Y, Y1, and Y2 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 本公开涉及新的式（I）化合物：其中R 1，R 2，R 2，R 3，R 3， p，A，B，Y，Y 1和Y 2具有本说明书中给出的含义及其盐，包含所述化合物的药物组合物及其用途为 蛋白激酶抑制剂。
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7.发明申请Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors 失效循环脲衍生物，其制备方法及其药物用途作为激酶抑制剂公开(公告)号：US20080004300A1
公开(公告)日：2008-01-03
申请号：US11627518
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Herve Bouchard
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Herve Bouchard
IPC分类号： A61K31/505 , A61P43/00 , C07D239/02
CPC分类号： C07D403/04
摘要： The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，L 1，X，R 3，A，R 4，R 4， R 4，R 4，R 5，Y和L 2如本文所定义，其盐和前药，用作蛋白激酶 抑制剂，以及治疗疾病的方法，包括给药。
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8.发明授权Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途公开(公告)号：US07759379B2
公开(公告)日：2010-07-20
申请号：US11627518
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
IPC分类号： C07D239/02 , A61K31/505 , A61P43/00
CPC分类号： C07D403/04
摘要： The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，L1，X，R3，A，R4，R4'，R4“，R4”'，R5，Y和L2如本文所定义， 作为蛋白激酶抑制剂的用途，以及治疗包括其施用的疾病的方法。
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9.发明授权Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素化合物，其制备及其作为激酶抑制剂的药物用途公开(公告)号：US07825115B2
公开(公告)日：2010-11-02
申请号：US11972314
申请日：2008-01-10
申请人： Marcel Patek , Anil Nair , Augustin Hittinger , Conception Nemecek , Daniel Bond , Greg Harlow , Herve Bouchard , Jacques Mauger , Jean-Luc Malleron , Mark Palermo , Fahad Al-Obeidi , Thomas Faitg , Hartmut Strobel , Sven Ruf , Kurt Ritter , Youssef El-Ahmad , Dominique Lesuisse , Didier Bénard
发明人： Marcel Patek , Anil Nair , Augustin Hittinger , Conception Nemecek , Daniel Bond , Greg Harlow , Herve Bouchard , Jacques Mauger , Jean-Luc Malleron , Mark Palermo , Fahad Al-Obeidi , Thomas Faitg , Hartmut Strobel , Sven Ruf , Kurt Ritter , Youssef El-Ahmad , Dominique Lesuisse , Didier Bénard
IPC分类号： C07D401/06 , C07D403/06 , A61K31/41
CPC分类号： C07D401/06 , C07D401/14
摘要： The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. Thus, the compound of formula I is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
摘要翻译： 本公开涉及式I的环脲化合物：如本文所定义，其制备方法，包含其的药物组合物及其作为蛋白激酶上的抑制剂的药物用途。 因此，式I化合物可用于预防或治疗能够通过抑制蛋白激酶如实体瘤的活性而被调节的生理障碍。
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10.发明授权Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途公开(公告)号：US07354933B2
公开(公告)日：2008-04-08
申请号：US10770382
申请日：2004-02-02
申请人： Marcel Patek , Anil Nair , Augustin Hittinger , Conception Nemecek , Daniel Bond , Greg Harlow , Herve Bouchard , Jacques Mauger , Jean-Luc Malleron , Mark Palermo , Fahad Al-Obeidi , Thomas Faitg , Hartmut Strobel , Sven Ruf , Kurt Ritter , Youssef El-Ahmad , Dominique Lesuisse , Didier Bénard
发明人： Marcel Patek , Anil Nair , Augustin Hittinger , Conception Nemecek , Daniel Bond , Greg Harlow , Herve Bouchard , Jacques Mauger , Jean-Luc Malleron , Mark Palermo , Fahad Al-Obeidi , Thomas Faitg , Hartmut Strobel , Sven Ruf , Kurt Ritter , Youssef El-Ahmad , Dominique Lesuisse , Didier Bénard
IPC分类号： C07D401/06 , C07D403/06 , A61K31/41
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
摘要翻译： 本发明涉及式I的环脲化合物：如本文所定义。 本发明还涉及其制备方法，包含其的药物组合物及其药物用途，作为蛋白激酶上的抑制剂。 因此，通过抑制蛋白激酶（例如实体瘤）的活性来预防或治疗能够调节的生理障碍是有用的。
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