公开(公告)号：US20050228075A1

公开(公告)日：2005-10-13

申请号：US10878656

申请日：2004-06-28

申请人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  Theodore Davidson ,  David Todd ,  Bainian Qian ,  Jun Yang

发明人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  Theodore Davidson ,  David Todd ,  Bainian Qian ,  Jun Yang

IPC分类号： C06B21/00 ,  C06B45/02 ,  C08J3/20 ,  C08K7/00 ,  C10L5/00 ,  D03D23/00

CPC分类号： C08J3/20 ,  C06B21/0025 ,  C06B21/0083 ,  C06B45/02

摘要： Techniques and methods of formation of ordered mixtures of particles by “clustering”. Clustering comprises local “structuring” consisting of a large “host” and smaller “guest” particles by various techniques. Small amounts of polymer are coated onto solid particles by various means. In one embodiment, an ordered mixture is created wherein the material that is of lesser quantity is of small particle size (the “B” particles) and the “A” particles are of larger size. The “B” particles are then coated onto a single A particle. By creating this ordered structure, each composite particle has the proper or stoichiometric amount of all ingredients. This dry composite material produced is appropriately used in various applications such as pharmaceutical formulations in the form of tablets, capsules, oral suspensions, inhalant, parenteral formulations and the like; energetics manufacture such as but not limited to explosives, propellants and pyrotechnics; agricultural products including but not limited to fertilizers, herbicides and pesticides; nutritional supplements and the like.

摘要翻译： 通过“聚类”形成有序粒子混合物的技术和方法。 聚类包括通过各种技术由大型“主机”和较小的“客体”粒子组成的本地“结构化”。 少量聚合物通过各种方式涂覆在固体颗粒上。 在一个实施方案中，产生有序混合物，其中少量的材料具有较小的粒度（“B”颗粒）和“A”颗粒的尺寸较大。 然后将“B”颗粒涂覆到单个A颗粒上。 通过创建这种有序结构，每个复合颗粒具有适当或化学计量的所有成分。 生产的这种干燥复合材料适用于各种应用，例如片剂，胶囊，口服悬浮液，吸入剂，肠胃外制剂等药物制剂; 能源制造，例如但不限于爆炸物，推进剂和烟火; 农产品包括但不限于化肥，除草剂和农药; 营养补品等。

公开(公告)号：US08163114B2

公开(公告)日：2012-04-24

申请号：US10819898

申请日：2004-04-07

申请人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  David Todd ,  Bainian Qian ,  Theodore Davidson

发明人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  David Todd ,  Bainian Qian ,  Theodore Davidson

IPC分类号： D03D23/00

CPC分类号： C08J3/20 ,  C06B21/0025 ,  C06B21/0083 ,  C06B45/02

摘要： Techniques and processes that combine particulate coating processes with particulate handling steps resulting in the formation of free-flowing particulates for introduction into energetic product vessels to affect an in-situ, net-shape manufactured product. The processes involve selecting suitably sized materials, processing such materials such that they are surface-coated and/or locally “structured” particulates, and pouring, preferably “dry” pouring, these processed materials into an energetic product vessel and infusing the filled vessel with a polymerizable and surface-compatible monomer or oligomer which flows into the unoccupied volume, followed by polymerization of the monomer, which then becomes the binder giving mechanical integrity to the final, net-shape energetic composition.

摘要翻译： 将颗粒涂层工艺与颗粒处理步骤相结合的技术和工艺，导致形成自由流动的颗粒，以引入高能产品容器中，以影响原位的网状制造产品。 这些方法包括选择适当尺寸的材料，加工这些材料使得它们被表面涂覆和/或局部“结构化”的颗粒，并将这些加工的材料倾倒，优选地“干”地浇注到高能产品容器中并将填充的容器注入 流动到未占据体积的可聚合和表面相容的单体或低聚物，随后聚合单体，然后其变成粘合剂，给最终的网状能量组合物提供机械完整性。

公开(公告)号：US20050224148A1

公开(公告)日：2005-10-13

申请号：US10819898

申请日：2004-04-07

申请人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  David Todd ,  Bainian Qian ,  Theodore Davidson

发明人： Costas Gogos ,  Ming-Wan Young ,  Rajesh Dave ,  Robert Pfeffer ,  David Todd ,  Bainian Qian ,  Theodore Davidson

IPC分类号： C06B21/00 ,  C06B45/02 ,  C08J3/20 ,  C08K7/00 ,  C10L5/00 ,  D03D23/00

CPC分类号： C08J3/20 ,  C06B21/0025 ,  C06B21/0083 ,  C06B45/02

摘要： Techniques and processes that combine particulate coating processes with particulate handling steps resulting in the formation of free-flowing particulates for introduction into energetic product vessels to affect an in-situ, net-shape manufactured product. The processes involve selecting suitably sized materials, processing such materials such that they are surface-coated and/or locally “structured” particulates, and pouring, preferably “dry” pouring, these processed materials into an energetic product vessel and infusing the filled vessel with a polymerizable and surface-compatible monomer or oligomer which flows into the unoccupied volume, followed by polymerization of the monomer, which then becomes the binder giving mechanical integrity to the final, net-shape energetic composition.

摘要翻译： 将颗粒涂层工艺与颗粒处理步骤相结合的技术和工艺，导致形成自由流动的颗粒，以引入高能产品容器中，以影响原位的网状制造产品。 这些方法包括选择适当尺寸的材料，加工这些材料使得它们被表面涂覆和/或局部“结构化”的颗粒，并将这些加工的材料倾倒，优选地“干”地浇注到高能产品容器中并将填充的容器注入 流动到未占据体积的可聚合和表面相容的单体或低聚物，然后聚合单体，然后其变成粘合剂，赋予最终的网状能量组合物机械完整性。

公开(公告)号：US20070053846A1

公开(公告)日：2007-03-08

申请号：US11512453

申请日：2006-08-30

申请人： Rajesh Dave ,  Robert Pfeffer ,  Jun Yang ,  Yuhua Chen

发明人： Rajesh Dave ,  Robert Pfeffer ,  Jun Yang ,  Yuhua Chen

IPC分类号： A61K9/28 ,  A61K9/14

CPC分类号： C23C24/04 ,  A61J3/02 ,  B22F1/0062 ,  B22F2202/15 ,  B22F2304/15 ,  C09D5/033

摘要： The present disclosure is directed to systems and methods for dry particle coating of cohesive powders, and to the dry coated particles/powders produced thereby. The present disclosure is further directed to systems and methods for dry coating of cohesive particles, particularly nanosized particles, to provide enhanced flowability and other advantageous physical and/or functional properties. The disclosed systems and methods offer downstream processing advantages, e.g., for purposes of subsequent fluidization, coating, granulation and/or other particle processing operations, and have applicability in wide ranging industries, including specifically paint-related applications, pharmaceutical applications, food-related applications, cosmetic applications, defense-related applications, electronics-related applications, toner and ink-related applications, and the like.

摘要翻译： 本公开涉及用于粘性粉末的干颗粒涂布的系统和方法以及由此产生的干涂层颗粒/粉末。 本公开进一步涉及用于干性涂布粘性颗粒，特别是纳米尺寸颗粒以提供增强的流动性和其它有利的物理和/或功能性质的系统和方法。 所公开的系统和方法提供下游处理优点，例如用于随后的流化，涂布，造粒和/或其它颗粒加工操作的目的，并且适用于广泛的行业，包括具体的油漆相关应用，药物应用，食品相关 应用，化妆品应用，国防相关应用，电子相关应用，调色剂和油墨相关应用等。

公开(公告)号：US20070120281A1

公开(公告)日：2007-05-31

申请号：US11594411

申请日：2006-11-08

申请人： Boris Khusid ,  Abhijit Gokhale ,  Rajesh Dave ,  Robert Pfeffer

发明人： Boris Khusid ,  Abhijit Gokhale ,  Rajesh Dave ,  Robert Pfeffer

IPC分类号： B29B9/00

CPC分类号： B01J2/04 ,  B01J2/006 ,  B01J3/008

摘要： An anti-solvent fluid technique is provided that assists in the formation, production and manufacture of fine particles including micro-sized and nanometer-sized particles for a wide variety of bio-medical and pharmaceutical applications. This technique is particularly effective for the manufacturing of polymers/biopolymers/drugs of micron, submicron or nano size as well as particle coating/encapsulation. Co-solvents are used to dissolve the polymer or mixture of polymers to make a solution. The method facilitates rapid drying of precipitated particles with reduced size and agglomerations. The method includes: (1) providing: an anti-solvent fluid; both organic solvents are soluble in the anti-solvent fluid; a second solvent that is at least partially soluble in or miscible with the first solvent; and a solute that is soluble in the first solvent and is substantially insoluble in the second solvent and the anti-solvent fluid; (2) capillary nozzle(s) are used to inject the solution into anti-solvent; (3) contacting the first solvent, the second solvent and the solute together to form a solution; (4) contacting the solution with the anti-solvent fluid to extract both solvents from the solution and precipitate the solute in the form of particles; and (5) contacting the solution with the anti-solvent fluids to extract both solvents from solution and precipitate the solute(s).

摘要翻译： 提供了一种抗溶剂流体技术，其有助于形成，生产和制造包括用于各种生物医学和药物应用的微尺寸和纳米尺寸颗粒的细颗粒。 该技术对于制备微米，亚微米或纳米尺寸以及颗粒涂层/包封的聚合物/生物聚合物/药物是特别有效的。 共溶剂用于溶解聚合物或聚合物混合物以制成溶液。 该方法有助于快速干燥具有减小的尺寸和聚集的沉淀颗粒。 该方法包括：（1）提供：反溶剂流体; 两种有机溶剂均溶于反溶剂液体; 至少部分可溶于第一溶剂或与第一溶剂混溶的第二溶剂; 以及可溶于第一溶剂且基本上不溶于第二溶剂和反溶剂流体的溶质; （2）毛细喷嘴用于将溶液注入反溶剂中; （3）将第一溶剂，第二溶剂和溶质接触在一起形成溶液; （4）使溶液与反溶剂流体接触，从溶液中提取两种溶剂，并以颗粒形式沉淀溶质; 和（5）使溶液与反溶剂流体接触以从溶液中萃取两种溶剂并沉淀溶质。

公开(公告)号：US07645327B2

公开(公告)日：2010-01-12

申请号：US11416034

申请日：2006-05-02

申请人： Robert Pfeffer ,  Rajesh Dave ,  Stanislav Dukhin ,  Jose A. Quevedo ,  Qun Yu

发明人： Robert Pfeffer ,  Rajesh Dave ,  Stanislav Dukhin ,  Jose A. Quevedo ,  Qun Yu

IPC分类号： B01D29/02

CPC分类号： B01D46/30 ,  B01D39/04 ,  B01D46/003 ,  B01D2239/0258 ,  B01D2279/51 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/776 ,  Y10S977/777 ,  Y10S977/778

摘要： Systems and methods for achieving filtration are provided that utilize agglomerates or granules of nanoparticles. The agglomerates or granules of nanoparticles may be used as and/or incorporated into a HEPA filtration system to remove solid or liquid submicron-sized particles, e.g., MPPS, in an efficient and efficacious manner. The filtration systems and methods are provided that utilize agglomerates or granules in a size range of about 100-500 microns. The agglomerates or granules of nanoparticles exhibit a hierarchical fractal structure. In the case of agglomerates of nanoparticles, porosities of 0.9 or greater are generally employed, and for granules of nanoparticles, porosities that are smaller than 0.9 may be employed. Filter media formed from the agglomerates or granules may be formed from materials such as carbon black and fumed silica, and may be employed in baffled or non-baffled filtration apparatus.

摘要翻译： 提供用于实现过滤的系统和方法，其利用纳米颗粒的附聚物或颗粒。 纳米颗粒的附聚物或颗粒可以用作和/或并入HEPA过滤系统中以有效和有效的方式除去固体或液体亚微米尺寸的颗粒，例如MPPS。 提供了使用约100-500微米尺寸范围内的附聚物或颗粒的过滤系统和方法。 纳米颗粒的团聚体或颗粒呈现分层结构。 在纳米颗粒附聚物的情况下，通常使用0.9或更大的孔隙率，并且对于纳米颗粒的颗粒，可以使用小于0.9的孔隙率。 由附聚物或颗粒形成的过滤介质可以由诸如炭黑和煅制二氧化硅的材料形成，并且可以用于挡板或非挡板过滤装置中。

公开(公告)号：US20090293719A1

公开(公告)日：2009-12-03

申请号：US11416034

申请日：2006-05-02

申请人： Robert Pfeffer ,  Rajesh Dave ,  Stanislav Dukhin ,  Jose A. Quevedo ,  Qun Yu

发明人： Robert Pfeffer ,  Rajesh Dave ,  Stanislav Dukhin ,  Jose A. Quevedo ,  Qun Yu

IPC分类号： B01D53/02 ,  B01D46/30 ,  B01D45/08 ,  B01D29/58 ,  B01D50/00

CPC分类号： B01D46/30 ,  B01D39/04 ,  B01D46/003 ,  B01D2239/0258 ,  B01D2279/51 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/776 ,  Y10S977/777 ,  Y10S977/778

摘要： Systems and methods for achieving filtration are provided that utilize agglomerates or granules of nanoparticles. The agglomerates or granules of nanoparticles may be used as and/or incorporated into a HEPA filtration system to remove solid or liquid submicron-sized particles, e.g., MPPS, in an efficient and efficacious manner. The filtration systems and methods are provided that utilize agglomerates or granules in a size range of about 100-500 microns. The agglomerates or granules of nanoparticles exhibit a hierarchical fractal structure. In the case of agglomerates of nanoparticles, porosities of 0.9 or greater are generally employed, and for granules of nanoparticles, porosities that are smaller than 0.9 may be employed. Filter media formed from the agglomerates or granules may be formed from materials such as carbon black and fumed silica, and may be employed in baffled or non-baffled filtration apparatus.

摘要翻译： 提供用于实现过滤的系统和方法，其利用纳米颗粒的附聚物或颗粒。 纳米颗粒的附聚物或颗粒可以用作和/或并入HEPA过滤系统中以有效和有效的方式除去固体或液体亚微米尺寸的颗粒，例如MPPS。 提供了使用约100-500微米尺寸范围内的附聚物或颗粒的过滤系统和方法。 纳米颗粒的团聚体或颗粒呈现分层结构。 在纳米颗粒附聚物的情况下，通常使用0.9或更大的孔隙率，并且对于纳米颗粒的颗粒，可以使用小于0.9的孔隙率。 由附聚物或颗粒形成的过滤介质可以由诸如炭黑和煅制二氧化硅的材料形成，并且可以用于挡板或非挡板过滤装置中。

公开(公告)号：US20050191491A1

公开(公告)日：2005-09-01

申请号：US10820091

申请日：2004-04-07

申请人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

发明人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

IPC分类号： A61K9/50 ,  A61K9/51 ,  B01J2/00 ,  B05D3/00 ,  B32B5/16 ,  B32B9/00 ,  C08J3/21 ,  C09D7/12 ,  C09D11/00

CPC分类号： A61K9/5153 ,  A61K9/5031 ,  A61K9/5089 ,  A61K9/5192 ,  B01J2/006 ,  C08J3/212 ,  C08K9/08 ,  C09D7/40 ,  C09D11/52 ,  Y02P20/544 ,  Y10T428/25 ,  Y10T428/2998

摘要： A process, method and/or system for preparing polymer-coated nanoparticles and/or other ultrafine particles utilizing a supercritical fluid, e.g., supercritical carbon dioxide (SC CO2), as an antisolvent that may be added to a solution of a polymer and an organic solvent in which insoluble nanoparticles or the like are suspended. The coating process occurs when the supercritical fluid (e.g., SC CO2) and the nanoparticle-containing suspension are combined to cause the suspended nanoparticles to precipitate as coated nanoparticles. Processing parameters for optimizing and/or enhancing the efficacy and/or efficiency of the coating process, method and/or system and for controlling the coating and/or agglomeration of coated particles are also described. The process, method and/or system has wide ranging applicability, e.g., for coating and/or encapsulation of pharmaceuticals, cosmetics, food products, chemicals, agrochemicals, pesticides, polymers, coatings, catalysts and the like.

摘要翻译： 使用超临界流体（例如超临界二氧化碳（SC CO 2 2））制备聚合物涂覆的纳米颗粒和/或其它超细颗粒作为可加入的抗溶剂的方法和/或系统 涉及悬浮有不溶性纳米粒子等的聚合物和有机溶剂的溶液。 当超临界流体（例如SC CO 2 H 2）和含纳米颗粒的悬浮液组合以引起悬浮的纳米颗粒作为包覆的纳米颗粒沉淀时，发生涂覆过程。 还描述了用于优化和/或增强涂覆工艺，方法和/或系统的功效和/或效率以及用于控制涂覆颗粒的涂覆和/或附聚的加工参数。 方法，方法和/或系统具有广泛的适用性，例如用于药物，化妆品，食品，化学品，农业化学品，农药，聚合物，涂料，催化剂等的涂覆和/或包封。

公开(公告)号：US20060086834A1

公开(公告)日：2006-04-27

申请号：US10900868

申请日：2004-07-27

申请人： Robert Pfeffer ,  Caroline Nam ,  Rajesh Dave ,  Guangliang Liu ,  Jose Quevedo ,  Qun Yu ,  Chao Zhu

发明人： Robert Pfeffer ,  Caroline Nam ,  Rajesh Dave ,  Guangliang Liu ,  Jose Quevedo ,  Qun Yu ,  Chao Zhu

IPC分类号： B02C19/06

CPC分类号： B01F13/0809 ,  B01F11/0266 ,  B01F13/0255 ,  B01J8/1872 ,  B01J8/40 ,  B01J8/42 ,  B01J19/10 ,  B01J2208/00681 ,  B82Y15/00

摘要： With the coupling of an external field and aeration (or a flow of another gas), nanoparticles can be smoothly and vigorously fluidized. Multiple external fields and/or pre-treatment may be employed with the fluidizing gas: sieving, magnetic assistance, vibration, acoustic/sound or rotational/centrifugal forces. Any of these forces, either alone or in combination, when coupled with a fluidizing medium, provide excellent means for achieving homogenous nanofluidization. The additional force(s) help to break channels as well as provide enough energy to disrupt the strong interparticle forces, thereby establishing an advantageous agglomerate size distribution. Enhanced fluidization is reflected by at least one of the following performance-related attributes: reduced levels of bubbles within the fluidized system, reduced gas bypass relative to the fluidized bed, smooth fluidization behavior, reduced elutriation, a high level of bed expansion, reduced gas velocity levels to achieve desired fluidization performance, and/or enhanced control of agglomerate size/distribution. The fluidized nanoparticles may be coated, surface-treated and/or surface-modified in the fluidized state. In addition, the fluidized nanoparticles may participate in a reaction, either as a reactant or a catalyst, while in the fluidized state.

摘要翻译： 通过外场和通气（或另一种气体的流动）的耦合，纳米颗粒可以顺利且剧烈流化。 多种外部场和/或预处理可以与流化气体一起使用：筛分，磁辅助，振动，声/声或旋转/离心力。 当与流化介质结合时，单独或组合的这些力中的任何一个提供了实现均匀纳米流化的极好手段。 额外的力有助于破坏通道，并提供足够的能量来破坏强大的颗粒间力，从而建立有利的团聚体尺寸分布。 增强的流化反应由以下性能相关属性中的至少一个反映：流化系统内的气泡水平降低，相对于流化床的气体旁路减少，流化性能平稳，淘汰率降低，床膨胀高度降低 速度水平以实现期望的流化性能，和/或增强聚集体尺寸/分布的控制。 流化的纳米颗粒可以在流化状态下被涂覆，表面处理和/或表面改性。 此外，流化的纳米颗粒可以在流化状态下作为反应物或催化剂参与反应。

公开(公告)号：US07537803B2

公开(公告)日：2009-05-26

申请号：US10820091

申请日：2004-04-07

申请人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

发明人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

IPC分类号： B05D7/00 ,  C08J7/16 ,  B01J19/10 ,  B29B9/08

CPC分类号： A61K9/5153 ,  A61K9/5031 ,  A61K9/5089 ,  A61K9/5192 ,  B01J2/006 ,  C08J3/212 ,  C08K9/08 ,  C09D7/40 ,  C09D11/52 ,  Y02P20/544 ,  Y10T428/25 ,  Y10T428/2998

摘要： A process, method and/or system for preparing polymer-coated nanoparticles and/or other ultrafine particles utilizing a supercritical fluid, e.g., supercritical carbon dioxide (SC CO2), as an antisolvent that may be added to a solution of a polymer and an organic solvent in which insoluble nanoparticles or the like are suspended. The coating process occurs when the supercritical fluid (e.g., SC CO2) and the nanoparticle-containing suspension are combined to cause the suspended nanoparticles to precipitate as coated nanoparticles. Processing parameters for optimizing and/or enhancing the efficacy and/or efficiency of the coating process, method and/or system and for controlling the coating and/or agglomeration of coated particles are also described. The process, method and/or system has wide ranging applicability, e.g., for coating and/or encapsulation of pharmaceuticals, cosmetics, food products, chemicals, agrochemicals, pesticides, polymers, coatings, catalysts and the like.

摘要翻译： 使用超临界流体（例如超临界二氧化碳（SCCO 2））制备聚合物涂覆的纳米颗粒和/或其它超微粒子的方法，方法和/或系统作为可以加入到聚合物溶液中的抗溶剂 其中悬浮有不溶性纳米颗粒等的有机溶剂。 当超临界流体（例如SCCO 2）和含纳米颗粒的悬浮液组合以引起悬浮的纳米颗粒作为包覆的纳米颗粒沉淀时，发生涂覆过程。 还描述了用于优化和/或增强涂覆工艺，方法和/或系统的功效和/或效率以及用于控制涂覆颗粒的涂覆和/或附聚的加工参数。 方法，方法和/或系统具有广泛的适用性，例如用于药物，化妆品，食品，化学品，农业化学品，农药，聚合物，涂料，催化剂等的涂覆和/或包封。