公开(公告)号：US20220333139A1

公开(公告)日：2022-10-20

申请号：US17621052

申请日：2020-06-17

Applicant: Council of Scientific and Industrial Research

Inventor： Srivari CHANDRASEKHAR ,  Subhash GHOSH ,  Avula Shiva KRISHNA ,  Chada Raji REDDY ,  Gangarajula SUDHAKAR ,  Kumaraguru THENKRISHNAN ,  Srihari PABBARAJA ,  Prathama Satyendra MAINKAR ,  Rajesh NASAM

IPC: C12P7/04 ,  C12P7/625 ,  C12P41/00 ,  C12N9/20

Abstract: The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.