公开(公告)号：US20240077492A1

公开(公告)日：2024-03-07

申请号：US17822757

申请日：2022-08-26

申请人： Cowper Sciences Inc.

发明人： Matthew GREVING ,  David SMITH ,  Gaurav SAINI

IPC分类号： G01N33/68 ,  B01J19/00 ,  C07K16/32 ,  C12N15/10

CPC分类号： G01N33/6845 ,  B01J19/0046 ,  C07K16/32 ,  C12N15/1055 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00725 ,  C07K2317/34 ,  C07K2317/92

摘要： Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

公开(公告)号：US20230096980A1

公开(公告)日：2023-03-30

申请号：US17816691

申请日：2022-08-01

申请人： Cowper Sciences Inc.

发明人： Robert KUIMELIS ,  Gaurav SAINI ,  David SMITH ,  Tommy ARMSBY

IPC分类号： C07D233/02 ,  G03F7/20 ,  C07C233/13 ,  C07C319/06 ,  C07C231/12 ,  C07F7/18 ,  G03F9/00

摘要： Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.

公开(公告)号：US20240159770A1

公开(公告)日：2024-05-16

申请号：US18420570

申请日：2024-01-23

申请人： Cowper Sciences Inc.

发明人： Matthew GREVING ,  David SMITH ,  Gaurav SAINI

IPC分类号： G01N33/68 ,  A61K39/395 ,  B01J19/00 ,  C07K16/32 ,  C12N15/10

CPC分类号： G01N33/6845 ,  A61K39/395 ,  A61K39/39558 ,  B01J19/0046 ,  C07K16/32 ,  C12N15/1055 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00725 ,  C07K2317/34 ,  C07K2317/92

摘要： Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

公开(公告)号：US20220290005A1

公开(公告)日：2022-09-15

申请号：US17824528

申请日：2022-05-25

申请人： Cowper Sciences Inc.

发明人： Gaurav SAINI ,  David SMITH ,  Patrick WALSH ,  Jae H. PARK

IPC分类号： C09D183/08 ,  B05D1/00 ,  C07F7/08 ,  C08F30/08 ,  C08G77/26 ,  C09D143/04 ,  G01N33/543 ,  C08G65/336 ,  C07F7/18

摘要： Molecules or salts thereof are provided, having the structure in Formula I,
wherein n2 and n4 are the same or different and are independently 1, 2, or 3, and n3 is 1 to 20; X is oxygen, nitrogen, or sulfur; wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. Methods are also provided for the synthesis of and use of the provided molecules in applications for diagnostic testing.