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公开(公告)号：US20080146533A1
公开(公告)日：2008-06-19
申请号：US11881738
申请日：2007-07-27
IPC分类号： A61K31/397 , A61K31/5375 , A61K31/498 , A61P9/10 , A61P31/04 , A61P13/12 , A61K31/445 , A61K31/40
CPC分类号： A61K31/397 , A61K31/40 , A61K31/445 , A61K31/498 , A61K31/5375 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , Y02A50/473
摘要： The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
摘要翻译： 本发明提供通过抑制GlyCer合酶抑制葡萄糖基神经酰胺（GlyCer）形成的氨基神经酰胺样化合物，从而降低糖鞘脂的含量。 本发明的化合物具有改善的GlcCer合酶抑制活性，因此可用于治疗与改变的鞘糖脂水平相关的各种病症和疾病的治疗方法。
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公开(公告)号：US20090312392A1
公开(公告)日：2009-12-17
申请号：US12387273
申请日：2009-04-30
IPC分类号： A61K31/40 , C07D207/04 , A61P43/00
CPC分类号： A61K31/397 , A61K31/40 , A61K31/445 , A61K31/498 , A61K31/5375 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , Y02A50/473
摘要： The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
摘要翻译： 本发明提供通过抑制GlyCer合酶抑制葡萄糖基神经酰胺（GlyCer）形成的氨基神经酰胺样化合物，从而降低糖鞘脂的含量。 本发明的化合物具有改善的GlcCer合酶抑制活性，因此可用于治疗与改变的鞘糖脂水平相关的各种病症和疾病的治疗方法。
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公开(公告)号：US07196205B2
公开(公告)日：2007-03-27
申请号：US11091836
申请日：2005-03-28
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , A61K31/4025 , C07D295/185 , C07D319/18 , C07D498/04
摘要： Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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4.发明授权Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors 有权UDP-葡萄糖的合成：N-酰基鞘氨醇葡糖基转移酶抑制剂公开(公告)号：US07615573B2
公开(公告)日：2009-11-10
申请号：US11702425
申请日：2007-02-05
IPC分类号： A61K31/40 , A61K31/445 , A61K31/5375 , C07D405/06
CPC分类号： C07D405/06 , A61K31/4025 , C07D295/185 , C07D319/18 , C07D498/04
摘要： Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
摘要翻译： 公开了UDP-葡萄糖：N-酰基鞘氨醇葡糖基转移酶的新型对映体合成神经酰胺样抑制剂。 还公开了在合成过程中形成的新型中间体。
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公开(公告)号：US07253185B2
公开(公告)日：2007-08-07
申请号：US11119541
申请日：2005-04-29
IPC分类号： A61K31/445 , A61K31/40 , C07D207/04 , C07D211/06
CPC分类号： A61K31/397 , A61K31/40 , A61K31/445 , A61K31/498 , A61K31/5375 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , Y02A50/473
摘要： The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
摘要翻译： 本发明提供通过抑制GlyCer合酶抑制葡萄糖基神经酰胺（GlyCer）形成的氨基神经酰胺样化合物，从而降低糖鞘脂的含量。 本发明的化合物具有改善的GlcCer合酶抑制活性，因此可用于治疗与改变的鞘糖脂水平相关的各种病症和疾病的治疗方法。
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公开(公告)号：US06916802B2
公开(公告)日：2005-07-12
申请号：US10839497
申请日：2004-05-05
IPC分类号： A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/451 , A61K31/5377 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , C07D413/02 , A61K31/5375 , C07D207/16 , C07D211/34
CPC分类号： A61K31/397 , A61K31/40 , A61K31/445 , A61K31/498 , A61K31/5375 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , Y02A50/473
摘要： The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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