公开(公告)号：US09200064B2

公开(公告)日：2015-12-01

申请号：US14513162

申请日：2014-10-13

申请人： Crucell Holland B.V.

发明人： Ronald Vogels ,  Theodorus Hendrikus Jacobus Kwaks

IPC分类号： A61K49/00 ,  A61K39/395 ,  A61K39/42 ,  A61K39/38 ,  A61K39/145 ,  C12Q1/70 ,  C07K16/10 ,  G01N33/569 ,  A61K47/48 ,  A61K39/00

CPC分类号： C07K16/1018 ,  A61K39/42 ,  A61K47/6841 ,  A61K2039/505 ,  C07K16/10 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11

摘要： Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.

公开(公告)号：US20160002318A1

公开(公告)日：2016-01-07

申请号：US14857587

申请日：2015-09-17

申请人： Crucell Holland B.V.

发明人： Ronald Vogels ,  Theodorus Hendrikus Jacobus Kwaks

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61K47/48

CPC分类号： C07K16/1018 ,  A61K39/42 ,  A61K47/6841 ,  A61K2039/505 ,  C07K16/10 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11

摘要： Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.

公开(公告)号：US20150037345A1

公开(公告)日：2015-02-05

申请号：US14513162

申请日：2014-10-13

申请人： Crucell Holland B.V.

发明人： Ronald Vogels ,  Theodorus Hendrikus Jacobus Kwaks

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/1018 ,  A61K39/42 ,  A61K47/6841 ,  A61K2039/505 ,  C07K16/10 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11

摘要： Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.

摘要翻译： 描述了结合乙型流感病毒的血凝素的结合分子，例如人单克隆抗体，并且对这种流感病毒具有广泛的中和活性。 这些结合分子不结合甲型流感病毒的血细胞凝集素。 进一步提供编码结合分子的核酸分子和包含结合分子的组合物。 结合分子可用于诊断，预防和/或治疗乙型流感病毒感染。