公开(公告)号：US20100317732A1

公开(公告)日：2010-12-16

申请号：US12811144

申请日：2008-12-29

申请人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

发明人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

IPC分类号： A61K31/35 ,  A61K31/165 ,  C07C211/00 ,  A61P35/02 ,  A61P35/04

CPC分类号： A61K31/277 ,  A61K31/165 ,  A61K31/353 ,  C07C235/34 ,  C07C255/54 ,  C07C291/10 ,  C07D311/92

摘要： Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

摘要翻译： 公开了增强肿瘤细胞化学治疗，降低癌细胞对化学治疗剂的抗性的方法，抑制患有癌症的哺乳动物中的ABCG2，Pgp或MRP1的方法，以及增加ABCG2的生物利用度的方法 哺乳动物中的底物药物。 所述方法包括向哺乳动物施用有效量的某些化合物，例如式（I）的化合物：式（I），其中R 1，R 2，R 3，X 1，X 2，X 3，a和b如上所述 这里。 还公开了这些化合物在制备药物中的用途。 还公开了式（II）的化合物，包含这些化合物的药物组合物及其用途。

公开(公告)号：US08470888B2

公开(公告)日：2013-06-25

申请号：US12811144

申请日：2008-12-29

申请人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

发明人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

IPC分类号： A61K31/12 ,  C07C59/86

CPC分类号： A61K31/277 ,  A61K31/165 ,  A61K31/353 ,  C07C235/34 ,  C07C255/54 ,  C07C291/10 ,  C07D311/92

摘要： Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

摘要翻译： 公开了增强肿瘤细胞化学治疗，降低癌细胞对化学治疗剂的抗性的方法，抑制患有癌症的哺乳动物中的ABCG2，Pgp或MRP1的方法，以及增加ABCG2的生物利用度的方法 哺乳动物中的底物药物。 所述方法包括向哺乳动物施用有效量的某些化合物，例如式（I）的化合物：式（I），其中R 1，R 2，R 3，X 1，X 2，X 3，a和b如上所述 这里。 还公开了这些化合物在制备药物中的用途。 还公开了式（II）的化合物，包含这些化合物的药物组合物及其用途。

公开(公告)号：US06673830B2

公开(公告)日：2004-01-06

申请号：US09887375

申请日：2001-06-22

申请人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

发明人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

IPC分类号： A01N4316

CPC分类号： C07D493/14

摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

公开(公告)号：US06774141B1

公开(公告)日：2004-08-10

申请号：US09083249

申请日：1998-05-20

申请人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman

发明人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman

IPC分类号： A01N4316

CPC分类号： C07D493/14

摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

摘要翻译： 根据本发明的方法，本发明提供了可以从植物中分离或衍生自Calophyllum属植物的化合物的新的抗病毒化合物，被称为calanolides，相关化合物及其衍生物。 化合物及其衍生物可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合用于抑制病毒如逆转录病毒，特别是人类免疫缺陷病毒，特别是HIV-1的生长或复制 或HIV-2。

公开(公告)号：US5859049A

公开(公告)日：1999-01-12

申请号：US653006

申请日：1996-05-24

申请人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

发明人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

IPC分类号： A61K31/365 ,  A61K31/366 ,  A61K36/18 ,  A61K45/06 ,  A61P31/12 ,  A61P31/18 ,  C07D493/14 ,  C07D493/22 ,  A61K31/37

CPC分类号： C07D493/14 ,  C07D493/22

摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

公开(公告)号：US5591770A

公开(公告)日：1997-01-07

申请号：US65618

申请日：1993-05-21

申请人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

发明人： Michael R. Boyd ,  John H. Cardellina, II ,  Kirk R. Gustafson ,  James B. McMahon ,  Richard W. Fuller ,  Gordon M. Cragg ,  Yoel Kashman ,  Doel Soejarto

IPC分类号： A61K31/365 ,  A61K31/366 ,  A61K36/18 ,  A61K45/06 ,  A61P31/12 ,  A61P31/18 ,  C07D493/14 ,  C07D493/22 ,  A61K31/37

CPC分类号： C07D493/14 ,  C07D493/22

摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

摘要翻译： 根据本发明的方法，本发明提供了可以从植物中分离或衍生自Calophyllum属植物的化合物的新的抗病毒化合物，被称为calanolides，相关化合物及其衍生物。 化合物及其衍生物可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合用于抑制病毒如逆转录病毒，特别是人类免疫缺陷病毒，特别是HIV-1的生长或复制 或HIV-2。

公开(公告)号：US5283383A

公开(公告)日：1994-02-01

申请号：US835637

申请日：1992-02-18

申请人： Michael R. Boyd ,  John H. Cardellina, II ,  Richard W. Fuller ,  Kenneth M. Snader ,  Jon Clardy

发明人： Michael R. Boyd ,  John H. Cardellina, II ,  Richard W. Fuller ,  Kenneth M. Snader ,  Jon Clardy

IPC分类号： A61K36/02 ,  A61K31/02 ,  A61P35/00 ,  A61P35/02 ,  C07C17/38 ,  C07C21/14 ,  C07C21/02 ,  A01N29/02 ,  A61K31/035

CPC分类号： C07C21/14

摘要： The present invention relates to a new antitumor compound, a method for isolating same from a red alga, antitumor compositions containing same and methods of using same for treating patients with cancer. The compound of the present invention is 6(R)-bromo-3(S)-bromomethyl-7-methyl-2,3,7-trichloro-1-octene.

摘要翻译： 本发明涉及一种新的抗肿瘤化合物，一种从红藻中分离的方法，含有该抗肿瘤药物的抗肿瘤组合物及其用于治疗癌症患者的方法。 本发明的化合物是6（R） - 溴-3（S） - 溴甲基-7-甲基-2,3,7-三氯-1-辛烯。