公开(公告)号：US20040061852A1

公开(公告)日：2004-04-01

申请号：US10672114

申请日：2003-09-26

Applicant: CyBio AG

Inventor： Juergen Wulf ,  Andreas Fina ,  Michael Eberhard

IPC: G01J001/10

CPC classification number: G01N21/278 ,  G01N21/6452

Abstract: The invention is directed to a device for calibrating an optical detection channel for a two-dimensional, spatially dependent measurement of fluorescent or luminescent radiation in multi-specimen carriers. The object of the invention, to find a novel possibility for calibrating an optical detection channel for a two-dimensional, spatially dependent measurement of fluorescent or luminescent radiation in multi-specimen carriers permitting a highly accurate calibration of the spatial sensitivity distribution of the sensor array in the detection channel which is economical, can be repeated at any time and can be adapted to the intensity level of the measurement task, is met according to the invention by providing a plate-shaped housing which is manufactured in the shape and size of the multi-specimen carriers under examination and has, on its side facing the detection channel, a large-area rectangular window whose size is adapted to the surface of the multi-specimen carrier under examination, which surface is provided with wells, and there is a luminescent foil inside the housing which is arranged parallel to the window so as to cover its surface, and a power source and control units are provided in the housing for controlling the luminescent foil, so that the luminescent foil can be controlled for homogeneous emission of luminescent light through the window of the housing in different intensity levels.

Abstract translation: 本发明涉及用于校准用于多样本载体中的荧光或发光辐射的二维空间依赖性测量的光学检测通道的装置。 本发明的目的是找到用于校准用于在多个样本载体中进行二维空间依赖性测量荧光或发光辐射的光学检测通道的新颖可能性，允许高精度校准传感器阵列的空间灵敏度分布 在经济的检测通道中，可以在任何时间重复并且可以适应于测量任务的强度水平，根据本发明通过提供一种板形壳体来制造，该板状壳体的形状和尺寸 多个试样载体正在检查中，并且在其面向检测通道的一侧具有尺寸适合于被检查的多试样载体的表面的大面积矩形窗口，该表面设有孔，并且存在一个 壳体内的发光箔，其平行于窗口布置以覆盖其表面，电源和控制单元是专用的 在壳体内设置用于控制发光箔，从而可以控制发光箔以不同强度水平均匀地发射通过壳体的窗口的发光。