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公开(公告)号：US20210241859A1
公开(公告)日：2021-08-05
申请号：US17163423
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for determining trial designs is provided. The method includes obtaining simulation data for a set of trial designs. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria; determining an optimality criteria for evaluating the trial designs; searching, within the set of trial designs, for globally optimum designs based on the optimality criteria; and recommending globally optimum designs.
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公开(公告)号：US20210240883A1
公开(公告)日：2021-08-05
申请号：US17163424
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes obtaining a criteria for a trial design study, determining permutations for designs in response to the criteria, and determining permutations for scenarios in response to the criteria. The method may further include generating combinations of the permutations for the designs and the permutations for the scenarios, simulating designs corresponding to the generated combinations, and determining performance of the simulated designs.
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公开(公告)号：US20210241864A1
公开(公告)日：2021-08-05
申请号：US17163436
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for trial design with simulated annealing includes obtaining, via at least one processor of a trial design platform, initial trial design simulation results data for a set of trial designs. The method may further include identifying an initial design from the design simulation results data, predicting, performance data of designs for variations of parameters corresponding to the set of trial designs, and identifying a new design for simulation by varying parameters of the initial simulated design based on the predicting. The method may also include simulating the new design, determining performance data of the new design, and identifying a second new design for simulation by varying parameters of the new design based on the simulated performance of the new design.
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公开(公告)号：US20210241863A1
公开(公告)日：2021-08-05
申请号：US17163433
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted available resources value. The method may further include determining, via the at least one processor, which subgrouping of the plurality of possible sites has a predicted available resources value that globally optimizes a desired site resource criteria.
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公开(公告)号：US20210241866A1
公开(公告)日：2021-08-05
申请号：US17163438
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for trial design includes presenting on a graphical interface, a set of cards, wherein each card in the set is representative of a different trial design from a set of trial designs. The method further includes: monitoring a first set of user interactions with the set of cards; determining a user preference for one or more values of one or more parameters of the set of trial designs from the first set of user interactions; and presenting on the graphical interface a new card that is representative of a trial design consistent with the determined user preference. The method may also include monitoring a second set of user interactions with the new card and refining the determined user preference based at least in part on the second set of user interactions with the new card.
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公开(公告)号：US20210241860A1
公开(公告)日：2021-08-05
申请号：US17163425
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.
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公开(公告)号：US20210241144A1
公开(公告)日：2021-08-05
申请号：US17163427
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes obtaining trial design simulation results for a set of trial designs and determining a set of Pareto designs in the set of trial designs based at least in part on the trial design simulation results and one or more performance parameters. The method further includes determining a set of convex hull designs in the set of trial designs, determining a set of recommended designs based at least in part on the set of Pareto designs and the set of convex hull designs, and transmitting the set of recommended designs.
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公开(公告)号：US12051488B2
公开(公告)日：2024-07-30
申请号：US17163438
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC分类号： G16H10/20 , G06F30/27 , G06N5/04 , G06N20/00 , G06Q10/067 , G06Q10/101 , G16H40/20 , G16H50/50 , G06F3/0484 , G06F111/06
CPC分类号： G16H10/20 , G06F30/27 , G06N5/04 , G06N20/00 , G06Q10/067 , G06Q10/101 , G16H40/20 , G16H50/50 , G06F3/0484 , G06F2111/06
摘要： A method for trial design includes presenting on a graphical interface, a set of cards, wherein each card in the set is representative of a different trial design from a set of trial designs. The method further includes: monitoring a first set of user interactions with the set of cards; determining a user preference for one or more values of one or more parameters of the set of trial designs from the first set of user interactions; and presenting on the graphical interface a new card that is representative of a trial design consistent with the determined user preference. The method may also include monitoring a second set of user interactions with the new card and refining the determined user preference based at least in part on the second set of user interactions with the new card.
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9.发明申请公开(公告)号：US20210319158A1
公开(公告)日：2021-10-14
申请号：US17354639
申请日：2021-06-22
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes generating a plurality of base datasets using a random number generator and determining scenario specifications. The method may further include identifying at least one transformation function for at least one of the plurality of base datasets based on the scenario specifications and transforming the at least one of the plurality of base datasets using the at least one transformation function. In some cases, the method may also include generating scenario parameters based on the at least one transformed datasets.
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公开(公告)号：US20210241862A1
公开(公告)日：2021-08-05
申请号：US17163432
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC分类号： G16H10/20
摘要： A method, according to some implementations, includes receiving, via at least one processor, output data of a plurality of trial design simulations for a plurality of scenarios and evaluating, via the at least one processor, the output data to determine changes in performance over the plurality of scenarios. The method may further include generating, via the at least one processor, visual tornado diagram data structured to generate a visual tornado diagram on an electronic display of an electronic device and transmitting, via the at least one processor, the visual tornado diagram data to the electronic device.
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