公开(公告)号：US20210269888A1

公开(公告)日：2021-09-02

申请号：US17253067

申请日：2019-07-01

Applicant: Cytiva Sweden AB

Inventor： Key Hyckenberg ,  Helena Skoglar ,  Gunnar Malmquist ,  Mikael Carlsten ,  Roger Lundqvist ,  Dan Andersson ,  Linda Mathiasson ,  Lars Mattsson ,  Sara Sendabo ,  Mikael Berg

IPC: C12Q3/00 ,  C12M1/36 ,  C12M1/00 ,  C12M1/34

Abstract: The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.