公开(公告)号：US20210269888A1

公开(公告)日：2021-09-02

申请号：US17253067

申请日：2019-07-01

Applicant: Cytiva Sweden AB

Inventor： Key Hyckenberg ,  Helena Skoglar ,  Gunnar Malmquist ,  Mikael Carlsten ,  Roger Lundqvist ,  Dan Andersson ,  Linda Mathiasson ,  Lars Mattsson ,  Sara Sendabo ,  Mikael Berg

IPC: C12Q3/00 ,  C12M1/36 ,  C12M1/00 ,  C12M1/34

Abstract: The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.

公开(公告)号：US11255829B2

公开(公告)日：2022-02-22

申请号：US15763520

申请日：2016-09-29

Applicant: Cytiva Sweden AB

Inventor： Helena Skoglar ,  Bjorn Olovsson

IPC: G01N30/38 ,  G01N30/74 ,  G01N30/20 ,  G01N30/78 ,  G01N35/10 ,  B01D15/18 ,  G01N30/62 ,  G01N30/42

Abstract: The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.